Visceral leishmaniasis and haemophagocytic syndrome in an Omani child
Journal Title: Sultan Qaboos University Medical Journal - Year 2002, Vol 4, Issue 1
Abstract
The paper reports the case of a previously healthy 4-year-old-girl who presented with pallor, fever and hepatosplenomegaly. Laboratory findings included pancytopenia, hypertriglyceridemia and hyperferritinemia. Initial diagnosis of kala-azar could not be confirmed because of the absence of clinical evidence, negativity of bone marrow aspiration or specific serology for visceral leishmaniasis. Repeated marrow aspiration, performed due lack of clinical response, revealed histiocytes showing haemophagocytosis consistent with haemophagocytic lymphohistocytosis (HLH) and appropriate treatment was started. She continued to have high-grade fever, and a third bone marrow aspiration ultimately revealed presence of Leishmania amastigotes with evidence of active haemophagocytosis. The girl was treated with liposomal amphotericin (AmBisome) for 5 days, following which she recovered rapidly with definitive remission.
Authors and Affiliations
Khalfan Al Sineidi| Department of Child Health (Haematology/Oncology Unit), College of Medicine & Health Sciences, Sultan Qaboos University, P.O.Box: 35, Al Khod-123, Sultanate of Oman. Department of Haematology, Sultan Qaboos University Hospital, P.O.Box: 38, Al Khod-123, Sultanate of Oman, Yasser A. Wali| Department of Child Health (Haematology/Oncology Unit), College of Medicine & Health Sciences, Sultan Qaboos University, P.O.Box: 35, Al Khod-123, Sultanate of Oman. Department of Haematology, Sultan Qaboos University Hospital, P.O.Box: 38, Al Khod-123, Sultanate of Oman, Anil V. Pathare| Department of Child Health (Haematology/Oncology Unit), College of Medicine & Health Sciences, Sultan Qaboos University, P.O.Box: 35, Al Khod-123, Sultanate of Oman. Department of Haematology, Sultan Qaboos University Hospital, P.O.Box: 38, Al Khod-123, Sultanate of Oman, Zakia Al Lamki| Department of Child Health (Haematology/Oncology Unit), College of Medicine & Health Sciences, Sultan Qaboos University, P.O.Box: 35, Al Khod-123, Sultanate of Oman. Department of Haematology, Sultan Qaboos University Hospital, P.O.Box: 38, Al Khod-123, Sultanate of Oman
Keywords
Related Articles
- EP ID EP13663
- DOI -
- Views 392
- Downloads 17
Compliance with the National Palestinian Infection Prevention and Control Protocol at Governmental Paediatric Hospitals in Gaza Governorates
Objectives: Nosocomial infections are a signifcant burden for both patients and the healthcare system. For this reason, infection prevention and control (IPC) practices are extremely important. Te Palestinian Ministry...
One in Three: Congenital Bent Bone Disease and Intermittent Hyperthermia in Three Siblings with Stuve-Wiedemann Syndrome
Stuve-Wiedemann syndrome (STWS) is a rare disorder characterised by congenital bowing of the long bones, contractures of the joints, neonatal onset of respiratory distress, sucking and swallowing difculties, dysautonom...
The Need for Psychological Interventional Supportive Services for Omani Women Diagnosed with Breast Cancer
Understanding the Influenza A H1N1 2009 Pandemic
A new strain of Influenza A virus, with quadruple segment translocation in its RNA, caused an outbreak of human infection in April 2009 in USA and Mexico. It was classifed as Influenza A H1N1 2009. Te genetic materia...
Qualitative Research and its Uses in Health Care
Although relatively uncommon in health care research, qualitative research is now receiving recognition and is increasingly used in health care research with social and cultural dimensions. Unlike quantitative research,...