Viscosupplementation for treatment of osteoarthritis of the knee
Journal Title: Annales Academiae Medicae Silesiensis - Year 2017, Vol 71, Issue
Abstract
INTRODUCTION: Osteoarthritis of the knee (gonarthritis – GA) is one of the most common musculoskeletal disorders. Pain and limitation of joint movement are the most constant and troublesome symptoms of the joint pathology. The aim of the study was to examine viscosupplementation therapy with hyaluronic acid. MATERIAL AND METHODS: 96 patients were administered hyaluronic acid unilaterally (the 1K group), while 33 patients were administered hyaluronic acid bilaterally (the 2K group) in a 40-day cycle. The stage of the disease was assessed based on medical history, physical examination and a questionnaire survey. Analysis of the following parameters was performed: serum level of sulfhydryl groups (SH), total oxidant status (TOS), catalase activities (CAT) and glutathione peroxidase (GPx) in erythrocytes and superoxide dismutase activity (SOD) in plasma and erythrocytes. RESULTS: Viscosupplementation resulted in pain reduction and improvement in the HHS score. The SOD and CAT activities were significantly decreased, while GPx activity as well as the SH level significantly increased in both the examined groups. In addition the TOS values significantly decreased. CONCLUSION: Viscosupplementation therapy with hyaluronic acid significantly reduces pain of the knee joint, improves its function and has a beneficial effect on the pro/antioxidant balance in the blood of patients diagnosed with GA. The effects of uni- and bilateral administration of hyaluronic acid are similar.
Authors and Affiliations
Alina Beata Ostałowska, Sławomir Święchowicz, Bogdan Koczy, Tomasz Stołtny, Dariusz Nowak, Marta Skowron, Ewa Birkner
Keywords
Related Articles
- EP ID EP349619
- DOI 10.18794/aams/62723
- Views 76
- Downloads 0
Endoscopic Ultrasonography (EUS) in Diagnostics and Treatment of Bile Duct Stones. The Current Role of ERCP
Precise evaluation of the presence of bile duct stones, performed using the most non-invasive method, is important for the planning of optimal treatment. Not only simple imaging procedures (like conventional transabdomin...
Socio-economic burden of cardiovascular diseases in Poland and Central Europe
Cardiovascular diseases cause over 4 million deaths each year in the societies of fifty-three countries of the World Health Organization’s European region. Over 1.9 million deaths occur in European Union countries. In 20...
The role of osteoprotegerine in pathogenesis of mineral and bone disorders in chronic kidney disease (CKD-MBD)
Mineral and bone disorders are the most common pathology in patients with chronic kidney disease (CKD) resulting in the development of accelerated atherosclerosis. Therefore, they are considered as non-traditional cardio...
An unusual manifestation of clear cell carcinoma – case report
The metabolism of neoplastic cells is perceived as the cause of atherothrombotic incidents in cancers since the 19th century. Those incidents occur in 1–11% cancer cases. In clear cell carcinoma, accounting for 5% of ova...
Ciężka postać rabdomiolizy wtórna do ostrego zatrucia alkoholem
W pracy zaprezentowano przypadek 66-letniego mężczyzny, u którego w wyniku ostrego zatrucia alkoholem doszło do rabdomiolizy manifestującej się klinicznie ostrym uszkodzeniem nerek oraz gwałtownym wzrostem aktywności fos...