Visfatin as a predictor for growth of fetus and infant
Journal Title: Turkish Journal of Obstetrics and Gynecology - Year 2018, Vol 15, Issue 2
Abstract
Objective: Visfatin is an adipocytokine that functions as an enzyme and a growth factor to investigate the relationship between serum visfatin and the fetus’s anthropometric markers up to a year after birth. Materials and Methods: Forty-one eligible pregnant women in their first trimester were divided and matched in terms of body mass index (BMI) before pregnancy into normal and higher than normal BMI groups, A and B. Serum visfatin levels were measured during 6-12 and 15-20 weeks of gestation using ELISA. Results: The infants were followed up for a mean duration of 10.19±2.83 months. In group A, there was a strong positive relationship between birth head circumference and the first (p1=0.054, r1=0.580) and second trimester visfatin levels (p2=0.051, r2=0.530). In group B, second trimester visfatin levels correlated negatively with birth length (p=0.015, r=-0.523) and infant’s head circumference (p2=0.050, r2=-0.392). In a separate study on group B, visfatin levels in the first and second trimesters showed a significant negative correlation with infant’s weight. A significant correlation was observed between the first and second trimesters visfatin level with infant’s height in both groups, such that this relationship was positive in group A and negative in group B. Linear regression analysis revealed that first and second trimester visfatin levels were significant independent predictors of infant’s weight in group B and infant’s height in both groups. Second trimester visfatin level was a significant predictor of birth height in group B. Conclusion: Maternal serum visfatin level shows a relationship with fetal and infant anthropometric indicators, with different effects in the two groups, suggesting visfatin dysfunction in the overweight group before pregnancy.
Authors and Affiliations
Ashraf Saber Mashhad Taraqi, Najmeh Tehranian, Marzieh Faghani Aghoozi, Somayeh Yousefi, Anoshirvan Kazemnejad, Shiva Pourali Roudbaneh, Matin Sadat Esmaeilzadeh
Keywords
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- EP ID EP365338
- DOI 10.4274/tjod.48091
- Views 103
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