Visfatin levels in non-obese, obese, and insulin resistant adolescents
Journal Title: Paediatrica Indonesiana - Year 2016, Vol 56, Issue 5
Abstract
Background Adipose tissue is not merely a site for energy storage, but is also the largest endocrine organ, secreting various adipocytokines. Plasma visfatin, an adipocytokine predominantly secreted from visceral adipose tissue, has insulin-mimetic effects, and has been closely linked to insulin resistance.Objective To compare plasma visfatin levels between obese and non-obese adolescents, as well as between obese adolecents with and without insulin resistance.Methods This cross-sectional study was conducted in students who attended three senior high schools in Padang. Subjects comprised 28 obese and 28 non-obese adolescents. The age of the subjects ranged from 14-18 years. Obesity criteria were based on body mass index (BMI) measurements. Fasting serum glucose level was measured by glucose hexokinase photometry and serum insulin was measured by chemiluminesence immunoassay. Plasma visfatin was measured by enzyme-linked immunosorbent assay (ELISA). The insulin resistance index was estimated from fasting serum insulin and glucose levels using the homeostatic model assessment for insulin resistance (HOMA-IR). Differences in the variables were tested using independent T-test and Mann-Whitney test, depending on the distribution of the variables.Results The mean plasma visfatin level was significantly higher in the obese than in the control group [2.55 (SD 1.54) vs. 1.61 (SD 0.64) ng/mL, respectively; (P=0.005)]. The insulin resistant group had significantly higher mean plasma visfatin level than the non-resistant group [3.61 (SD 1.59) vs. 1.96 (SD 1.18) ng/mL, respectively; (P=0.004)].Conclusion Obese adolescents with insulin resistance have signifcantly higher plasma visfatin levels compared to those without insulin resistance.
Authors and Affiliations
Indra Ihsan, Eka Rini, Rismawati Yaswir
Keywords
Related Articles
- EP ID EP446153
- DOI 10.14238/pi56.5.2016.291-6
- Views 71
- Downloads 0
Hunter syndrome with hyperthyroidism: a 16 month follow-up reprt
Mucopolysaccharidosis (MPS) is a rare genetic disorder caused by a deficiency in the activity of lysosomal enzymes required for glycosaminoglycan (GAG) degradation. An accumulation of GAG in many organs results in progre...
Triiodothyronine levels and mortality in children with sepsis and septic shock
Background Sepsis is the most common cause of death in infants and children. It can cause hormonal imbalances, such as euthyroid sick syndrome (ESS), which may increase the risk of death.Objective To evaluate a possible ...
Effectiveness of amitriptyline for treating functional dyspepsia in adolescents
Background Functional dyspepsia is common among adolescents. Pain reduces children’s quality of life, psychosocial functioning, and school attendance. Amitriptyline is assumed to be one of the alternative treatments in f...
Physical activity assessments in obese and non-obese adolescents using the Bouchard diary
Background Obesity is now a global epidemic problem. Increasedprevalence of obesity is associated with increased sedentarybeh avior and low physical activity.Objective To assess the physical activity patterns of adolesce...
Prognostic value of nitric oxide in pediatric septic shock
Background Nitric oxide (NO) play a key role in the pathogenesis of septic shock. Nitrit oxide metabolite is reported as a good predictor for shock although its role as mortality predictor in sepsis still controversial.O...