Visual Field Changes in Patients Receiving Antitubercular Drug Therapy at Tertiary Care Hospital: An Analytical Observational Study
Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 2
Abstract
Introduction: Tuberculosis is a worldwide public health problem. The antitubercular drugs which affect the optic nerve are isoniazid and ethambutol. The ethambutol induced toxic optic neuropathy is quite common while that induced by isoniazid is rare. Sudy aimed to evaluate visual field changes in tubercular patients with DOTS therapy (directly observed treatment short course). Material and Methods: A prospective clinical study was conducted on 100 patients suffering from tuberculosis attending the DOTS centre of Government Medical College and Associated hospitals, Srinagar. The patients were evaluated for visual field changes after exposure to DOTS therapy over a period of time. Results: In the present study of 100 patients, 198 eyes were examined. It was found that 13.63% eyes developed changes in visual fields after the two months exposure of DOTS therapy. When the therapy was stopped for two months, 66.66% eyes showed improvement in their visual field. The most common defect seen among such patients were peripheral defects in different quadrants (8.1%). Conclusion: In the present study we concluded that ethambutol therapy in tubercular patients, when taken according to the recommended dose and duration, can cause ocular toxicity in the form of visual field changes. Significant number of patients showed an improvement in visual field after cessation of therapy.
Authors and Affiliations
Mahrukh A, Ambrine Ashraf, Mohd Ayaz Bhat
Keywords
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