VITAMIN C INCREASES THE LEVEL OF LACTATE DEHYDROGENASE IN RATS ‘ORAL SQUAMOUS CELL CARCINOMA
Journal Title: Journal of Experimental Biology and Agricultural Sciences - Year 2018, Vol 6, Issue 2
Abstract
Since the discovery of vitamin C many studies have illustrated its characteristic effect as a tumor prevention agent. Conversely: the extracellular presence of lactate dehydrogenase (LDH) is associated with cell necrosis and tissue breakdown and is therefore considered as a tumor marker. In present study effects of vitamin C on the levels of oral LDH was estimated during the development of squamous oral carcinoma. Histological findings of study revealed changes in the oral tissue of the animals treated with dimethyl benzanthracene (DMBA) alone or DMBA associated with vitamin C such as moderate dysplasia associated with basal cell hyperplasia. Notably: differentiated oral squamous cell carcinoma was observed in the rats belonging to group injected with DMBA after 6 weeks. Otherwise: anaplastic oral carcinoma was observed after 5 weeks in group treated with DMBA and vitamin C. High levels of LDH were detected throughout the induction of the squamous cell carcinoma phases in comparison to the anaplastic phase. These findings demonstrate that the injection of DMBA in association with vitamin C accelerates the induction of anaplastic carcinoma and that these changes are associated with increased LDH levels in the differentiated squamous carcinoma compared with the undifferentiated carcinomas.
Authors and Affiliations
Sahar EL Hadad
Keywords
Related Articles
- EP ID EP590183
- DOI 10.18006/2018.6(2).443.452
- Views 57
- Downloads 0
Estimation of soil erosion risk, its valuation and economic implications for agricultural production in western part of Rwanda
Multifunctional soil conservation strategies have the capacity to control soil erosion as well as increase its quality, thus leading to sustained yields as long as planners have knowledge on the severity of soil loss. A...
A STUDY ON THE EFFECT OF CINNAMON AND CINNAMALDEHYDE ON BOVINE SERUM ALBUMIN (BSA) PROTEIN BY USING FT-RAMAN SPECTROSCOPY
FT-Raman spectroscopy revealed comparative intensity changes of many bands and wave number shifts, when comparing bovine serum albumin (BSA) separately, BSA mixed with 500 ppm cinnamaldehyde and BSA mixed with 500 ppm ci...
ASSOCIATION OF THE METABOLIC SYNDROME AND VITAMIN D RECEPTOR GENE POLYMORPHISMS: A CROSS SECTIONAL STUDY
The Vitamin D Receptor gene (VDR) expressed in many tissues and are able to modulate the expression of several other genes. The purpose of this study was to assess the association between the metabolic syndrome (MetSyn)...
RABIES, A VACCINE PREVENTABLE DISEASE: CURRENT STATUS, EPIDEMIOLOGY, PATHOGENESIS, PREVENTION AND CONTROL WITH SPECIAL REFERENCE TO INDIA
Rabies is a fatal viral zoonosis caused by lyssavirus. It affects warm blooded animals and humans. It is more prevalent in Asia, Africa and the Latin American countries. Although the exact magnitude of the disease is not...
EFFECT OF PROBIOTIC AND PRILLED FAT ON LACTATION PERFORMANCE OF CROSS BRED COW DURING TRANSITION PERIOD
In present study, combined effects of prilled fat and yeast culture (YC) mixture supplemented diet on 12 early lactating crossbred cows were evaluated. Cows were divided into two groups as control group (CON group) and s...