Vitamin-D and Thyroid : Permissive effects of vitamin-D on thyroid autoimmunity and cancer
Journal Title: Journal of the Indian Medical Association - Year 2018, Vol 116, Issue 5
Abstract
In spite of large volume of data linking vitamin-D with cardiovascular morbidity, autoimmunity, cancer, and virtually every organ system, vitamin-D and thyroid is a lesser-known aspect of vitamin-D in clinical practice. This article intends to highlight the pleotropic effects of vitamin-D on thyroid function and thyroid disorders. References for this review were identified through searches of PubMed, Medline, and Embase for articles published to November 2017 using the terms “thyroid” [MeSH Terms] AND “vitamin-D” [MeSH Terms] OR “thyroid” [All Fields] AND “vitamin-D” [All Fields]. Significant inverse correlation was documented between anti-thyroid peroxidase antibody (TPOAb) and serum 25-hydroxy-vitamin-D (25OHD) titers. TPOAb positivity is more prevalent in the vitamin D deficient individuals. Certain vitamin-D receptor (VDR) gene polymorphism have been linked to increased occurrence of autoimmune thyroid disorders (AITD). Short-term high dose oral vitamin-D supplementation reduces TPOAb titers. Vitamin-D deficiency, decreased circulating calcitriol has been linked to increased thyroid cancer. Certain VDR gene polymorphisms have been linked with increased as well as decreased occurrence of thyroid cancer. Data is scant on use of vitamin-D analogues for treating thyroid cancer. In spite of large volume of medical literature from observational and cross-sectional studies linking vitamin-D with thyroid autoimmunity and cancer, meaning concrete clinical data on impact of vitamin-D supplementation on hard clinical end points in these disorders is lacking, and should be the primary area of research in the next decade.
Authors and Affiliations
Deep Dutta, Sachin Chittawar, Deepak Khandelwal, Sameer Aggarwal
Keywords
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