Vitamin D Deficiency & Low Serum Calcium Levels in Hypothyroid Patients
Journal Title: International Journal of Contemporary Medical Research - Year 2018, Vol 5, Issue 1
Abstract
Introduction: Vitamin D deficiency prevails in epidemic proportion all over Indian sub continent. The role of vitamin D as a immune modulator has been emphasized in recent years. Low levels of Vitamin D were observed in several autoimmune diseases including multiple sclerosis, rheumatoid arthritis, SLE, Type I diabetes mellitus. Thyroid diseases are among the most common endocrine abnormalities. Currently there is no consensus regarding role of Vitamin D deficiency in hypothyroid patients. In present study we explored the probable interaction between vitamin D and Hypothyroidism and also tried to find any correlation between Serum Ca2+ levels and Thyroid disorder. Material and Methods: The present study was a cross sectional study conducted in the department of Internal medicines, ASCOMS Hospital Jammu. It was conducted from April to October (2017).We enrolled a total of 60 subjects in the study. Venous samples were collected from all patients. The quantitative determination of 25 (OH) vitamin D and Serum Ca2+ was done using spectrophotometer method. Levels of TSH, T3, T4 were estimated using fluorescence array. Statistical analysis were performed using SPSS software. All data presented as frequency and mean + SD, unpaired t-test was used to compare between two means of all parametric continuous variable. Chi-square test statistic was used to test association between categorical variables. Results: The following observations were deduced for the 60 subjects enrolled in the study. The mean levels of serum 25(OH) vitamin D was 16.20 ng/ml in hypothyroid group versus 49.93ng/ml in control group. This was statistically significant P = 0.001. There was significant negative correlation between 25 (OH) vitamin D and TSH levels in the hypothyroid group (r = -0.37 P = < 0.05).We also observed significant difference in levels of serum ca2+ between the two groups. Hypothyroid group serum ca2+ (7.29 + 0.40 mg/dl), control group serum ca2+ (9.92 + 0.43mg/dl) (t= -24.816 P= 0.000).A positive correlation was observed between 25 (OH) vitamin D and FT3 levels in hypothyroid groups though it was insignificant (r = 0.008 P =0.966). Conclusion:The study concluded that in hypothyroid patients, levels of 25 (OH) vitamin D and Serum ca2+ were significantly decreased. There may be a rationale for recommendation of vitamin D and calcium supplementation for hypothyroid patients.
Authors and Affiliations
Vikram Sharma, Anil Gupta, Rabia Showkat
Keywords
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