Vitamin D Status Appears Unrelated to Fractures in Patients with Chronic Kidney Disease
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2015, Vol 6, Issue 4
Abstract
Background: Although lack of Vitamin D is widespread in chronic kidney disease, data is scarce in the role Vitamin D may play in fractures in such cases. Methods: Retrospective analysis of all patients visiting Nephrology outpatients department in 1 UK District General Hospital over 2 years. Chronic kidney disease was categorised by estimated glomerular filtration rate, total Vitamin D and fracture details obtained from Hospital Information Technology system. Total Vitamin D <50nmol/L was considered inadequate. Logistic regression was used to assess the relationships of eGFR and total Vitamin D with fracture incidence. Spearman’s correlation coefficient (rs) was used to assess the relationship between continuous variables. Results: 43/66 patients were Vitamin D deficient - prevalence of Vitamin D deficiency was 65% (95% CI: 52%, 76%). 20/66 patients sustained any form of fracture, incidence of fracture in this chronic kidney disease population was 30% (95% CI: 20%, 43%). There was no association between total Vitamin D level and risk of fracture, OR 0.99 (95% CI: 0.97, 1.01), p = 0.316. The strength of the association between total Vitamin D level and fracture was also unrelated to estimated glomerular filtration level (interaction test, p = 0.971). There was no relationship between estimated glomerular filtration and total Vitamin D level (rs = -0.03, p = 0.8066). Estimated glomerular filtration was found to be negatively associated with risk of fracture, OR 0.96 (0.93, 1.00), p = 0.028. Conclusion: Vitamin D deficiency appears widely prevalent in chronic kidney disease with a third of patients sustaining fractures; total Vitamin D levels however are unrelated to fractures. Prospective interventional studies can help answer if earlier replacement of Vitamin D before chronic kidney disease develops will help improve musculoskeletal health and prevent fractures.
Authors and Affiliations
Anindya Banerjee
Keywords
Related Articles
- EP ID EP347096
- DOI 10.9734/BJMMR/2015/14532
- Views 80
- Downloads 0
Protection Effect of Different Fractions of Root of Lawsonia inermis on 2-Deoxyribose by Hydroxyl (.OH) Radical Assay
Aim: In vitro protective effect of different fractions of root of Lawsonia inermis (LI) on 2-deoxy ribose, sugar of the DNA were carried out in this study. Methods: Protective activity of different fractions of LI namely...
Plasma Fibrinogen in Chronic Obstructive Pulmonary Disease – A Cross Sectional Study Conducted in a Tertiary Care Hospital in Puducherry, India
Background: Chronic Obstructive Pulmonary Disease (COPD) is a systemic disorder rather than a respiratory disease. A significant complication that COPD can lead to a hypercoagulable state, which can lead to life-threaten...
The Role of Antigravity Treadmill in Haemophilic Children Aged 8 to 11 Years with Unilateral Knee Haemarthrosis without Radiological Involvement
Background: Recurrent joint bleeding in children with hemophilia leads to joint damage with pain, loss of range of motion and function. Antigravity treadmill (AGT) allows unloading of the lower extremities during exercis...
Vitamin D Status Appears Unrelated to Fractures in Patients with Chronic Kidney Disease
Background: Although lack of Vitamin D is widespread in chronic kidney disease, data is scarce in the role Vitamin D may play in fractures in such cases. Methods: Retrospective analysis of all patients visiting Nephrolo...
A Rare Intradural Extramedullary Calcifying Pseudoneoplasm of the Spine Presenting with Radiculopathy
Aims: Calcifying pseudoneoplasms of the neuroaxis (CPN) are rare, poorly understood lesions of the central nervous system that pose a diagnostic challenge because they mimic the more common calcified lesions of the neuro...