Vitamins C and E as Effective Protectors against Potassium Bromate-induced Cardiac Injury in Rats
Journal Title: Journal of Applied Life Sciences International - Year 2016, Vol 7, Issue 3
Abstract
Potassium bromate (KBrO3) is widely used in foods and water, in spite of its well-known oxidative cell and tissue damage. Therefore, vitamins C and E are examined to alleviate its cardiac injury. For this purpose 72 adult male albino rats were categorized into 6 groups. Group1 served as control; group 2 served 30 mg/Kg/ day vitamin C; group 3 served 300 mg/kg/day vitamin E; group 4 was injected intraperitoneally with KBrO3 20 mg/Kg/ dose twice weekly; and groups 5 and 6 received either vitamins C or E with KBrO3 in the same scheme. After 4 weeks, heart and serum were collected for analysis. KBrO3-induced cardiac injury was evidenced by a significant increase in serum asparate transaminase (AST), creatine phosphokinase isoenzyme (CK-MB) and lactate dehydrogenase (LDH) activities and cardiac troponin I (cTnI) level. Significant reduction in cardiac collagen synthesis and elevation in matrix metalloproteinase-1 (MMP-1) and tumor necrosis factor-α (TNF-α) were noticed in KBrO3-intoxicated rats. These changes were ameliorated in the vitamins C and E-treated groups through their antioxidant and anti-inflammatory properties.
Authors and Affiliations
Heba Barakat, Mai El-Sayed
Keywords
Related Articles
- EP ID EP351919
- DOI 10.9734/JALSI/2016/28697
- Views 53
- Downloads 0
Effect of Fertilization on Growth of Eucalyptus urophylla Plantation
Fertilization has been widely applied to increase and sustain productivity of plantations, especially in poor soils. N, P, K, and compost are usually used for forest plantation in Vietnam. The amount of fertilizer and ra...
Effect of Fermentation on the Microbial, Proximate and Mineral Composition of Mung Bean (Vigna radiata)
Aims: To examine the effect of fermentation on the microbial, proximate and mineral composition of mung bean. Study Design: Mung bean seed were obtained from local farmers in Ondo State, Nigeria. Unfermented sample was...
Novel Non-parametric Assessment of Heavy Metals in Coated Card Wastes
Non-parametric tests were applied for the first time to coated mobile card waste in order to determine the correlation within risk assessment and instrumentation. The AAS concentrations of all the metals were higher than...
Effects of Non-genetic Factors Affecting the Productive Performance of White Fulani and Friesian x White Fulani Genotypes in Kaduna, Nigeria
This research was conducted to assess the effects of genetic and non genetic factors on the productivity of commercial dairy herd in Kaduna. Nigeria. Data on 252 calving which comprised, 100 white Fulani calves (male 46,...
Spatio-Temporal Variation of Actual Evapotranspiration of Lower River Kaduna Catchment, Nigeria
Assessing spatio-temporal variation of actual evapotranspiration is very important, most especially in the areas that are prone to changing climate. Lower River Kaduna is one of the critical ecosystems in the northwest,...