Von Willebrand disease - broadening our vision: a pediatric case report with dental considerations
Journal Title: IP International Journal of Orthopaedic Rheumatology - Year 2017, Vol 4, Issue
Abstract
Von Willebrand disease is an autosomal inherited bleeding disorder caused due to the quantitative or qualitative defects of a multimeric glycoprotein, the Von Willebrand factor (VWF). VWF is a multi-adhesive protein that carries factor VIII in circulation and initiates aggregation of platelets to exposed sub endothelial collagen fibers. The deficiency or abnormality of VWF causes reduction in the levels of factor VIII, as seen in Hemophilia A patients. The common clinical manifestations of Von Willebrand disease include soft tissue and mucosal bleeding. The severity of the disease is determined by the extent of von Willebrand factor and factor VIII reduction in the circulation. Since symptoms are often mild, a significant majority of patients remain undiagnosed. This article presents the ongoing dental management of a seven-year old female diagnosed with Von Willebrand disease. The primary aim of the article is to focus on the diagnosis, management and dental considerations of this common yet overlooked disorder and distinguish it from Hemophilia.
Authors and Affiliations
Mridula Goswami, Deepti Thakkar
Keywords
Related Articles
- EP ID EP210793
- DOI 10.18231/2393-9834.2017.0016
- Views 113
- Downloads 0
Conventional tooth supported overdenture with metal reinforced opposing complete denture: A case report
The overdenture is a removable prosthesis that is supported by both selectively retained teeth and the residual ridge or mucosa. It is a versatile and successful means of achieving long-term restoration of a partially ed...
Preponderance of side of involvement in Osteoarthritis knee
Introduction: Osteoarthritis (OA) is a chronic inflammatory condition affecting the joint. Knee is the most commonly involved joint of body in osteoarthritis. Osteoarthritis may occur primarily in knee joint or it may be...
Efficacy of Mesenchymal Stem Cells (MScs) enhanced with Platelet Rich Plasma PRP in Osteoarthritis (OA) Treatment
Osteoarthritis (OA) is one of the most common joint diseases. This disease commonly develops in the weight bearing joints of the lower limbs, such as the knee and hip joints. Osteoarthritis is considered a chronic degene...
A hidden cause of troublesome bone pain in an adult-Brodie’s abscess
Introduction Brodie abscess (subacute osteomyelitis) is an infectious disease localized in metaphyseal bone(1). Brodie first described a localized abscess of the tibia in an amputated limb that did not produce systemic s...
Knowledge attitude and practice of Indian dentists on topical fluoride application in children
Objectives: To assess the knowledge, attitude and practice of dentists towards Topical fluoride application in Delhi, National Capital Region (NCR). Materials and Method: A self-made questionnaire was designed in a manne...