Vulvar Lesion Mimicking Vitiligo Revealing a Squamous Cell Carcinoma

Journal Title: Journal of Dermatology Research - Year 2023, Vol 4, Issue 1

Abstract

Melanocytes respond to trauma or cutaneous inflammation by producing varying amounts of melanin, which manifests as either hyperpigmentation or hypopigmentation. Post inflammatory Hypopigmentation (PIH) is an acquired partial or total loss of skin pigmentation that occurs after cutaneous inflammation or injury [1]. Mechanisms and pathogenesis of PIH remain unclear. It is difficult to understand how individuals respond to inflammation differently. Skin discoloration is the primary clinical indication of pigment incontinence [2]. Vitiligo, another disease that presents similarly, is often confused with PIH. Significant contrast in wood light and dermoscopy can lead to a positive diagnosis of vitiligo. The most common malignant neoplasm affecting the vulva is Vulvar Squamous Cell Carcinoma (VSCC). It accounts for approximately 90% of all cases of vulvar cancer. The majority of female vulvar squamous cell cancer cases occur after menopause [3]. The causes of VSCC are multifactorial, with a number of risk factors identified, including infection with Human Papillomavirus (HPV), chronic inflammation, and immunodeficiency [4].

Authors and Affiliations

Imane Kacimi Alaoui, Zakia Douhi, Siham Boularbah, Meryem Soughi, Sara Elloudi, Hanane Baybay, Fatima-Zahra Mernissi

Keywords

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  • EP ID EP715201
  • DOI https://doi.org/10.46889/JDR.2023.4108
  • Views 47
  • Downloads 0

How To Cite

Imane Kacimi Alaoui, Zakia Douhi, Siham Boularbah, Meryem Soughi, Sara Elloudi, Hanane Baybay, Fatima-Zahra Mernissi (2023). Vulvar Lesion Mimicking Vitiligo Revealing a Squamous Cell Carcinoma. Journal of Dermatology Research, 4(1), -. https://europub.co.uk/articles/-A-715201