Whole tumor MR Perfusion histogram analysis in the preoperative assessment of patients with gliomas: Differentiation between high- and low-grade tumors
Journal Title: Hellenic Journal of Radiology - Year 2017, Vol 2, Issue 1
Abstract
Purpose: To compare the diagnostic accuracy of normalized Blood Volume (nBV) histogram metrics in differentiating low from high-grade gliomas. Material and Methods: Forty-four patients (22 female, 22 male) with histologically confirmed gliomas were included. Group A comprised 10 patients with low grade gliomas (all grade II) while group B comprised 34 patients (4 grade III and 30 grade IV). Three-dimensional whole tumor segmentation was based on intensity level clustering in T2 FLAIR for the non-enhancing lesions or post contrast T1 weighted images for the enhancing lesions. Dynamic Susceptibility Contrast (DSC) perfusion was applied in all patients, and leakage corrected nBV maps were created. Corresponding histograms were generated from all the pixels included in the tumor volume. Minimum, maximum, mean, standard deviation, median, skewness, kurtosis, 5%, 30%, 70% and 95% percentiles, as well as normalized peak height and maximum peak position derived from normalized blood volume histograms were calculated for both groups. ROC analysis was performed to find optimum thresholds for differentiating between low and high grade gliomas. Results: 5% percentile of nBV normalized histogram provided the highest area under the curve (AUROC: 0.93) for the differentiation of low from high grade gliomas. A threshold value of 0.07 for the 5% percentile of nBV normalized histogram resulted in 90.8% sensitivity and 90% specificity. The positive and negative predictive values were 96.7% and 75%, respectively while the accuracy reached 91%. When removing 2 IDH mutation positive HGG patients, the corresponding AUROC increased to 0.98. Conclusion: Whole tumor normalized Blood Volume histogram analysis proved to be a very accurate method to differentiate low from high grade gliomas.
Authors and Affiliations
Vasileios K. Katsaros, Katerina Nikiforaki, Giorgos Manikis, Kostas Marias, Evangelia Liouta, Christos Boskos, George Kyriakopoulos, Nikolaos Papanikolaou
Keywords
Related Articles
- EP ID EP374030
- DOI -
- Views 114
- Downloads 0
Late-onset restless legs syndrome evaluated at night-hours with resting-state fMRI of the brain and voxel-based morphometry
Purpose: The aim of the study was to investigate the resting state networks and brain volumetric changes in patients with late onset restless legs syndrome (lRLS). Material and Methods: Nine untreated lRLS patients (m...
Terminal veins and neonatal intraventricular haemorrhage of prematurity: a sonographic approach
Purpose: To evaluate the sonographic appearance and velocities of terminal veins (TVs) in premature neonates without/with germinal matrix (GMH) or intraventricular haemorrhage (IVH), and to investigate for an early sonog...
Experience with the use of a dose management system in the everyday routine of a CT department. A touchstone or a millstone?
Purpose: A dose tracking software was recently installed in our CT department. The study aimed at evaluating the software capabilities and staff performance in every day routine. Material and Methods: A dose tracking s...
Painful swelling of lateral neck and submandibular area in a girl
An 8-years old girl presented at the Emergency Department with a painful swelling of the left lateral neck and submandibular area. The swelling had started 15 days earlier and worsened gradually. Five days after the init...
Bilateral Shoulder Pain
A 63-year-old male patient presented in the outpatient Orthopaedic Clinic with longstanding pain of both shoulders, more intense at night and at lying on the side. On clinical examination there was restricted movement, p...