Abstract

Wound dressings are frequently developed by introducing new products to target different aspects of the wound healing process. Many medicated dressings incorporated with natural extracts and chemicals have been developed. Chronic wounds could be invaded by many bacteria and Pseudomonas aeruginosa and Staphylococcus aureusare the most common. S. aureus and P. aeruginosa are usually detected in the higher layer of wounds or in the deepest region of wound bed, respectively. They can express many virulence factors affecting wound healing process and leading to severe infections and antibiotic resistance. Starch based impregnated gauze containing either N. sativa honey, myrtle berries hydro-alcoholic extract or a combination were prepared. There efficacy against both P. aeruginosa and S. aureus isolated from chronic wounds. N. sativa honey mixture was the most potent against P. aeruginosa with an inhibition zone diameter of 18.1±0.3 mm, while the myrtle berries hydro-alcoholic extract mixture was the most potent against S. aureus with an inhibition zone diameter of 18.4±0.5 mm. The prepared impregnated gauzes deliver a moist environment that helps wounds epithelialize more rapidly. In addition, honey and myrtle berries hydro-alcoholic extract provide antibacterial and anti-inflammatory properties that will accelerate the healing process of wounds. Keywords: Staphylococcus aureus, Pseudomonas aeruginosa, N. sativa honey, myrtle berries hydro-alcoholic extract, starch based impregnated gauzes

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