Wound Healing Activity of the Formulated Silver Chitosan Nanocomposite Cream against Alloxan-Induced Diabetic Wounded Animal Model
Journal Title: Open Access Journal of Pharmaceutical Research - Year 2018, Vol 2, Issue 3
Abstract
In the Philippines, the prevalence rate of diabetes is predicted to increase continuously making Filipinos more susceptible to diseases related to the disease above. Drug delivery system using nanotechnology has played a role in the formulation strategy to improve the therapeutic action. This technology offers the advantages of increased stability, enhanced in-vitro antibacterial property, variation in drug solubility and enhanced drug delivery to the action site. This research focuses on the formulation of Silver Chitosan Nanocomposite (SCN) Cream and its use as a wound healing agent using Alloxan Induced Animal Model. SCN with different concentration is developed and is characterized using the following parameters: (i) Transmission Electron Microscopy and (ii) Antibacterial assay. Optimized SCN is formulated into a cream and analyzed based on the following assay including (i) Viscosity test, (ii) Dermal irritation test and (iii) Histopathological evaluation of the wound healing property. The Optimized SCN cream (30% SCN) has exhibited antibacterial and wound healing property comparable to the silver sulfadiazine cream in treating the wound in diabetic patients in terms of epithelial formation.
Authors and Affiliations
Cecilia DS*, Jan Karlo TE, Ashley Marrion CA, Euriel Jasmin PC, Ariza RG, Carmela Ann BL, Althea VS and Celine AAAV
Keywords
Related Articles
- EP ID EP745920
- DOI 10.23880/oajpr-16000161
- Views 1
- Downloads 0
Investigation of Phytochemical Profile and Combine Synergistic Anti-Diarrheal Potential of Peperomia Pellucida Aerial Part and Cyprus Esculentus Root Extracts
Peperomia pellucida and Cyperus esculentuslocally found plant used for anti-diarrhoeal activity using standard animal model. The aerial parts of Peperomia pellucidaand Cyperus esculentuswere collected from Trikaripur for...
Transdermal Delivery Offer for Low Dose Acetylsalicylic Acid
The use of Acetyl Salicylic Acid (ASA) in the secondary prevention of cardio vascular diseases is well known. Orally administered ASA is rapidly metabolized to its principal metabolite Salicylic Acid (SA) in the gastroin...
Preparation Modification and Characterization of a Hydrogel Based on Polyacrylic and Polymetacrylic Acid as a Potential Carrier for Drug Delivery Systems
Complexes of polyacrylic acid (PAA) and polymethacrylic acid (PMA) in presence of sodium alginate (SAL) during redox polymerization of polyacids were formed. They were characterized by IR spectroscopy and viscometry. The...
Anthelmintic Activity of Methanolic Extract of Strychnos Colubrina L. Bark
Strychnoscolubrina L. (Loganiaceae) is being used in traditional medicine for a variety of ailments. One successive standard and three crude extract of its barks were subjected for anthelmintic activity on adult Indian e...
Phytochemical Screening of Some Spices Used as Condiment in Kano, North western Nigeria
Spices have been added to foods since ancient times, not only as flavouring agent, but also as food preservatives and folk medicines. The study was aimed to screened for qualitative and quantitative bioactive constituent...