Wound Healing Parameters at Different Time Intervals in Excision Wounds of Rabbit
Journal Title: Journal of Veterinary Advances - Year 2014, Vol 4, Issue 5
Abstract
Wound healing is a fundamental response to tissue injury and several integrated cellular and biochemical events are set in motion immediately after injury leading to re-establishment of structural and functional integrity with regains of strength of injured tissue. present study was under taken to study the accumulation of different biochemical molecules at the wound site at specific time intervals. 36 clinically healthy rabbits in the age group of 3-9 months were used as experimental animals. Wound contraction was recorded on day 2, 4, 6, 8, 10, 12 and 14 after creation of wound. Biochemical parameters hydroxyproline, glucosamine, protein and DNA was estimated at I hour, 3 hour, 6 hour, 24 hours, 5 days, 8 days, 11 and 14 post wounding days. There was a decrease in the wound area from day 2 and this trend continued up to the last observation of the study. On day 14 there was 100% contraction of the wound area. There was also an increase in the accumulation of hydroxyproline and glucosamine at the wound site from 1 hour and this trend continued up to last day of observation. The maximum accumulation of hydroxyproline and glucosamine, 17.20 ± 0.82 mg and 7.16 ± 0.52 mg respectively was observed on day 14. There was also an increase in protein and DNA content at the wound site from 1 hour. The peak in the accumulation of protein and DNA, 6.82 ± 0.14mg and 5.47 ± 0.18 mg respectively was observed on day 11 and a decrease on day 14, 5.30 ± 0.17 mg and 4.99 ± 0.31 mg. We observed complete healing on 14th post wounding day indicating active proliferation and remodeling that resulted in the reduction of wound size. There was increase in the hydroxyproline and glucosamine from 1 hour and this trend continued up to 14 days after creation of the wound, the increase in hydroxyproline content is the reflection of increased level of collagen levels, which indicates better maturation and proliferation of collagen while glucosamine is an essential moiety of proteoglycans.
Authors and Affiliations
S. Bilal , I. Hussain , S. A. Bhat , S. P. Ahmad , V. Tripathi , J. D. Parrah , A. B. Abidi
Keywords
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