WOUND HEALING POTENTIAL OF GRANDIFLORENIC ACID ISOLATED FROM WEDELIA TRILOBATA LINN.
Journal Title: Journal of Drug Delivery and Therapeutics - Year 2017, Vol 7, Issue 7
Abstract
The ethyl acetate fraction from ethanolic extract of W. trilobata leaves displayed antibacterial and fibroblast stimulatory activities thereby suggesting potential wound healing properties. Ethyl acetate fraction was further subjected to bioassay guided fractionation, which afforded isolation of grandiflorenic acid (GA). GA exhibited potential in vitro wound healing activity due to fibroblast stimulation and inhibiting inflammatory phase of wound healing, evident by reduced levels of inflammatory cytokines from macrophage RAW 264.7 cells. The aim of the present study was to evaluate wound healing activity of GA formulated in ointment base (0.5% and 1.0% w/w) using excision, incision and dead space wound models in experimental rats. Treatment of wound with isolated grandiflorenic acid 1.0% w/w topically exhibited significant (p<0.01) wound healing activity in all three models as compared to control groups. High rate of wound contraction, decrease in period of epithelialisation, high tensile strength, increase in dry granulation tissue weight.
Authors and Affiliations
Aayushi Kavachale
Keywords
Related Articles
- EP ID EP302209
- DOI -
- Views 76
- Downloads 0
ROLE OF CARBON SOURCE FOR THE PRODUCTION OF L-GLUTAMINASE FROM ASPERGILLUS ORYZAE
Microbial glutaminases are more stable than plant and animal counterparts. In addition to it, they have also been detected in mammalian tissues where they are the major enzymes responsible for catabolic breakdown of glut...
OPTIMIZATION OF THE RELEASE KINETICS OF DILTIAZEM HYDROCHLORIDE FROM TABLETED MICROSPHERES
Formulation F5, F6, F7 and F8 were selected to make the tablets because of their high percentage release (more than 90%). 500 mg weight of tablets containing 120 mg strength of Diltiazem hydrochloride were prepared from...
ANTI-ANAEMIC ACTIVITY OF HYDRO-ALCOHOLIC LEAF EXTRACT OF LUFFA AEGYPTIACA IN PHENYLHYDRAZINE INDUCED ANEMIC RATS
The main aim of the current study is to determine the anti-anaemic activity in hydro-alcoholic leaf extract of Luffa aegyptiaca in phenylhydrazine induced anemic rats. Phenylhydrazine (60mg/kg) was administered intraperi...
FORMULATION AND EVALUATION OF TABLETS CONTAINING ARTEMETHER MICROSPHERES AND LUMEFANTRINE
This study was aimed to fabricate and evaluate a combination of Artemether and Lumefantrine as tablets and to make Artemether in sustained form so as to prolong its elimination time. Artemether was formulated in form of...
A REVIEW UPDATE ON DILLENIA INDICA F.ELONGATA (MIQ.)MIQ.
Dillenia indica f. elongata (Miq.) Miq. (Dilleniaceae) commonly known as Elephant apple. The vernacular names include Chalta, Chulta, Karambel, Bhavya and Ramphal.It is found in Bangladesh, Nepal, China, Indonesia and As...