ww.iosrjournals.org DOI: 10.9790/0853-1606017885 www.iosrjournals.org 78 | Page Effects of Ultrasound versus Low Level Laser Therapy in Levofloxacin-Induced Rat Model of Knee Osteoarthritis
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 6
Abstract
Objectives. Osteoarthritis (OA) is one of the most common diseases affecting both aged and young people. Physiotherapy provides effective non-pharmacologic intervention for knee OA. Evidence for inflammation in OA is good predictive factor of OA progressions. The purpose of this study is to compare the effects of conventional Ultra Sound (US) and low level laser therapy (LLLT) on levels of inflammatory cytokines and histopathological changes in chemically-induced knee OA in rats. Methods. Eighteen male rats divided into three groups; (Lev) group treated with levofloxacin (Lev), (US) group treated with Lev plus US and (LLLT) group treated with Lev plus low level laser therapy. All animals received total of 200 mg injection of Lev. Total of ten sessions of US and laser applied. Results. We found significant decrease of serum IL-1beta, Mankin’s score and increase in knee extension angle in both US and LLLT groups compared to Lev group. US significantly lower IL-6, INF-gamma, CRP and significantly elevate IL-10 in US group compared to Lev and LLLT groups. Conclusion. Based on our finding, US may provide better therapeutic effect compared to LLLT in knee osteoarthritis as indicated by reduction of inflammatory cytokines, elevation of anti-inflammatory cytokines and better histopathological score. Abbreviations:Osteoarthritis (OA), Levofloxacin (Lev), Ultrasound (US), Low level laser therapy (LLLT), Levofloxacin (Lev), Interleukin 1 beta (IL-1β), Interleukin 6 (IL-6), Interleukin 10 (IL-10), Interferon gamma (INF-γ), C-reactive protein (CRP), Tumor necrosis factor alpha (TNF-α).
Authors and Affiliations
Ghada S Mahmoud, Mohamed Elbedewey, Ahmed M. Abdelkader, Ahmed B. Bekheet, Dina M. El- Kossy, Samir A. Sabbahi
Keywords
Related Articles
- EP ID EP600482
- DOI 10.9790/0853-1606017885.
- Views 115
- Downloads 0
Utility of simple urinary screening tests to rule out UTI in Pediatric population
Context: UTI is one of the important infection among pediatric population. Rapid screening test to rule out UTI can save time and it is very useful in areas where laboratory facilities are lacking. Aims: The study was ca...
A Retrospective Study of CNS Tumors
A total of 50 patients with CNS tumors were evaluated clinically and by imaging techniques followed by intraoperative examination and histopathological evaluation of the resected tumor. The age of the patients ranged fro...
Comparative Evaluation of Efficacy, Hemodynamic Stability and Recovery during Conscious Sedation with Dexmedetomidine or Propofol in Cardiac Catheterization Laboratory
Background:Conscious sedation provides calm and cooperative patient for interventional procedures. We compared dexmedetomidineand propofolin combination with fentanylfor conscious sedation during cardiac catheterization...
Root Amputation “A ray of hope” for decayed mandibular molar: A Case series
Introduction: A patient is more concern about his teeth and wants to preserve their teeth. Patient wants to preserve teeth by latest treatment option and method available. There are so many treatments available but our t...
Surgical audit of peptic perforation among Scheduled Tribe patients attending Bankura Sammilani Medical College and Hospital, India
Despite medical advances, duodenal ulcer perforation remains a surgical emergency. A prospective observational study was conducted from January 2013 to October 2014 involving 100 Tribal patients with suspected perforated...