Wybrane antybiotyki nukleozydowe
Journal Title: Wiadomości Chemiczne - Year 2017, Vol 71, Issue 1
Abstract
Every year there has been a growing increase in infections caused by strains of bacteria resistant to multiple drugs. This prompts scientists to search for new antibiotics that would be able to fight these infections. New therapeutics used in medicine, which offer greater hopes are nucleoside antibiotics. They represent a large family of natural compounds exhibiting a variety of biological functions [1]. These include antifungal, antiviral, antibacterial, insecticides, immunosuppressants or anticancer properties. These broad-spectrum antibiotics can be divided into three main groups: • antibacterial nucleoside antibiotics, responsible for the inhibition of bacterial translocation of phospho-N-acetylpentapeptides, involved in the biosynthesis of peptidoglycan cell wall of bacteria; • antifungal nucleoside antibiotics, which role is to inhibit chitin synthase, or stopping construction of the cell wall of fungi; • antiviral antibiotics nucleoside, their mechanism of action is mainly based on blocking the biosynthesis of proteins by peptide inhibition transferase. In recent years much attention has been focused on the construction, mechanism of action and biosynthesis of antibiotics [1–3]. The development of genetic engineering has opened the way for combinatorial biosynthesis and obtaining new or hybrid compounds. In this work we would like to discuss some of bioactive naturally occurring nucleoside antibiotics, such as tunicamycin (Fig. 6) [19–22], mureidomycin (Fig. 8) [31–34], muramycin (Fig. 9) [36] or capuramycin (Fig. 10) [38].
Authors and Affiliations
Justyna Samaszko-Fiertek, Barbara Dmochowska, Rafał Ślusarz, Janusz Madaj
Keywords
Related Articles
- EP ID EP568443
- DOI -
- Views 114
- Downloads 0
Badanie struktury i dynamiki N-terminalnych sekwencji dermorfiny i ich analogów z wykorzystaniem spektroskopii NMR w ciele stałym i rentgenografii
Deltorphin I (Tyr-d-Ala-Phe-Asp-Val-Val-Gly-NH_2) and dermorphin (Tyr-d-Ala-Phe- -Gly-Tyr-Pro-Ser-NH_2) are natural opioid peptides that have been isolated from the skin of South American frogs [1]. The presence of d-ami...
Dwuwymiarowa separacja technikami chromatografii i elektroforezy ze szczególnym uwzględnieniem połączenia ich w proces jednoetapowy
Liquid chromatography and electrophoresis techniques are very often applied in contemporary laboratory practice. These techniques usually show different separation selectivity. It is due to various separation mechanisms...
Aktywność biologiczna związków acetylenowych pochodzenia naturalnego
The natural acetylenic products containing at least one a carbon-carbon triple bond, are important class of compounds widely distributed in the environment. Development of spectroscopic techniques and methods for the iso...
Substancje aktywne preparatów do usuwania powłok lakierniczych
In most of paint removers organic solvent are used as active ingredients. The analysis of the literature on modern manufacture preparations allowed to identify the most commonly used solvent for this purpose i.e. methyle...
Zastosowanie spektroskopii w podczerwieni w adsorpcji i katalizie (II)
The review presents important results on infrared examination of adsorbents and catalysts, which were obtained in Laboratory of Adsorption and Catalysis in Environmental Protection at Adam Mickiewicz University – conduct...