Yield of stem cells from umbilical cord blood units collected in utero versus ex utero
Journal Title: IOSR Journal of Nursing and health Science - Year 2019, Vol 8, Issue 1
Abstract
Purpose: This study aims to compare yield of stem cells from umbilical cord blood units collected in utero versus ex utero. Methods: A descriptive comparative study was carried out at Labor and delivery room, operating room, and Research Center for Cord Stem Cells in Mansoura University, Egypt. A purposive sample of 124 pregnant mothers and their newborns were recruited, 62umbilical cord blood (UCB) units were collected in-utero and 62 units were collected ex utero from vaginal and cesarean birth fields. Data were collected through an assessment sheet. Results: The average UCB volume obtained in-utero was significantly larger than that obtained ex-utero by 8.7 ml, p=0.033. The in-utero collected UCB units provided significantly higher total nucleated cell (TNC) count by 1x106 /ml, p=0.040, and higher CD34+ counts by 3.7 (x103 )/ml, p=0.009 equated to those collected ex utero. The units collected from cesarean deliveries yielded larger blood volume (by 9.5 ml, p= 0.019), and higher TNC counts (by 1.3 (x106 )/ml and p=0.012), and higher CD34+ cell count (by 4.2 x103 /ml and p=0.003 compared to those collected from vaginal deliveries. Conclusion: UCB units collected in-utero provided larger blood volume and higher cellular content compared to the ex utero collection.
Authors and Affiliations
Tyseer Marzouk, Hanan Abd-Elmohdy Emarah, Reda Hemida, Mohammed Darwish, Farah El-Chennawi
Keywords
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- EP ID EP437610
- DOI 10.9790/1959-0801037077.
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