Ykl-40 and cancer antigen 72-4 as new and promising diagnostic and prognostic markers for endometrial cancer
Journal Title: Turkish Journal of Obstetrics and Gynecology - Year 2018, Vol 15, Issue 4
Abstract
Objective: To determine the predictive role of serum levels of YKL-40 and cancer antigen (CA) 72-4 in the diagnosis of endometrial cancer (EC). Materials and Methods: Forty-one patients with EC and 21 women with uterine polyps were evaluated between January and December 2015 in a prospective study. Results: Age, body mass index, preoperative serum YKL-40 and CA 72-4 levels were significantly higher in the malignant group compared with the control group. Serum YKL-40 levels were significantly higher in patients with superficial myometrial invasion and no lymph node involvement (p=0.042; p=0.004). No relationship between clinicopathologic factors and serum CA 72-4 levels was found. Conclusion: Serum CA 72-4 and YKL-40 levels are increased in women with EC compared with uterine polyps. Preoperative serum YKL-40 levels may be associated with favorable prognostic factors. The determination of YKL-40 before surgery may be helpful in the evaluation of the regional lymph nodes.
Authors and Affiliations
Suat Karataş, Veysel Şal, İlker Kahramanoğlu, Fuat Demirkıran, Tugan Beşe, Macit Arvas, Nigar Sofiyeva, Onur Güralp, Hafize Uzun
Keywords
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- EP ID EP436512
- DOI 10.4274/tjod.77906
- Views 108
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