Zero order and area under curve spectrophotometric methods for determination of Levocetirizine in pharmaceutical formulation
Journal Title: International Journal of Advances in Scientific Research - Year 2015, Vol 1, Issue 6
Abstract
Simple, fast and reliable spectrophotometric methods were developed for determination of Levocetirizine in bulk and pharmaceutical dosage forms. The solutions of standard and the sample were prepared in methanol. The quantitative determination of the drug was carried out using the zero order derivative values measured at 230 nm and the area under the curve method values measured at 227-234 nm (n=2). Calibration graphs constructed at their wavelengths of determination were linear in the concentration range of Levocetirizine using 5-25μg/ml (r²=0.998 and r²=0.999) for zero order and area under the curve spectrophotometric method. All the proposed methods have been extensively validated as per ICH guidelines. There was no significant difference between the performance of the proposed methods regarding the mean values and standard deviations. Developed spectrophotometric methods in this study are simple, accurate, precise and sensitive to assay of Levocetirizine in tablets.
Authors and Affiliations
Audumbar Digambar Mali, Ritesh Bathe, Manojkumar Patil, Ashpak Tamboli
Keywords
Related Articles
- EP ID EP333871
- DOI 10.7439/ijasr.v1i6.2253
- Views 86
- Downloads 0
Peptide Conjugated Lipid Nanoparticles and Cancer Drug Delivery
Peptide Conjugated Lipid Nanoparticles and their role on Cancer Drug Delivery are reviewed here. The benefits of nanotechnology and combination style of medicine delivery are still hindered without the active ligands nee...
Comparison and evaluation of ambient air quality at different nearby locations of LCL plant, 2014
The monitoring of ambient air quality is very important to evaluate the effect of running industry on environment. The Lahore compost Pvt. Ltd. has its own composting plant that utilizes tons of municipal solid waste to...
An unusal case of hematemesis in a patient with type 1 diabetes mellitus
Diabetes is a metabolic disorder characterised by hyperglycemia, with disturbances of carbohydrate, fat and protein metabolism. Here is the report of an unusual case of hematemesis in a patient with type 1 diabetes melli...
Synthesis of Evolvulus alsinoides derived gold nanoparticles for medical applications
Plant mediated synthesis of metallic nanoparticles is an increasing commercial demand due to the wide applicability in various areas such as electronics, catalysis, chemistry, energy, cosmetics and medicine. This is grea...
In silico analysis of fluoride transport proteins from prokaryotic and eukaryotic organisms
In silico analysis of Fluoride transporter proteins obtained from database are presented in this study. The composition of alanine and glycine was high while low concentrations of aspartic acid, cysteine and glutamine we...