Zika Virus Infection: An Ongoing Global Ferocity
Journal Title: Journal of Enam Meical College - Year 2017, Vol 7, Issue 1
Abstract
Zika virus is an arthropod-borne flavivirus transmitted by female Aedes aegypti mosquito which lives in tropical regions. However, the Aedes albopictus mosquito, which lives in temperate regions, is also capable of carrying it. Like other flaviviruses, Zika virus is enveloped and icosahedral. It has a nonsegmented, single-stranded and 10 kilobase positive-sense RNA genome. The envelope also contains two glycoproteins E and M; here the E protein binds with the host cell membrane followed by endocytic uptake, uncoating of the nucleocapsid and release of viral RNA into the cytoplasm. Immature virions are collected both in the endoplasmic reticulum and in secretory vesicles before being released.1 Flaviviruses generally replicate in the cytoplasm, but Zika virus antigens have been found in infected cell nuclei. The vertebrate hosts of the virus are primarily monkey and human. The pathogenesis of the virus is hypothesized to start with an infection of dendritic cells near the site of mosquito-bite, followed by spreads to the lymph nodes and also the blood stream.
Authors and Affiliations
Iftikhar Ahmed
Keywords
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- EP ID EP36283
- DOI https://doi.org/10.3329/jemc.v7i1.30743
- Views 300
- Downloads 0
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