ЗНАЧЕННЯ МІТОХОНДРІАЛЬНОЇ ДИСФУНКЦІЇ У РОЗВИТКУ НЕАЛКОГОЛЬНОГО СТЕАТОГЕПАТИТУ
Journal Title: Science Review - Year 2018, Vol 3, Issue 1
Abstract
Objective: Improvement of the diagnosis of non-alcoholic steatohepatitis (NASH) and the development of optimally effective methods for correcting the revealed violations. Materials and Methods: examined 65 patients with verified NASH. The age of the patients ranged from 23 to 67 years. Among them were 36 (55.4 %) women and 29 (44.6 %) men. The control group consisted of 20 healthy individuals. The effectiveness of complex therapy with the inclusion of the drug L-carnitine, deproteinized hemoderivat of calves and folic acid was studied. Results: The presence of carnitine insufficiency, hyperhomocysteinemia, increase in the level of proinflammatory cytokines in all patients with NASH. After a month of treatment with complex therapy, the level of L-carnitine increased from 14.5 (13.1, 15.7) μmol/l to 31.1 (28.8, 34.1) μmol/l (p<0.001), homocysteine decreased to subnormal figures - 11.8 (11.0, 12.8) μmol/l (p<0.001). When studying the cytokine profile in the group after treatment, a significant decrease in the level of proinflammatory cytokines was revealed. Conclusion: The use of complex therapy with the inclusion of drugs L-carnitine, deproteinized hemoderevate blood of calves as an antihypoxant and folic acid has a positive effect on the clinical course of the disease, contributes to the elimination of L-carnitine deficiency, hyperhomocysteinemia, a decrease in the level of pro-inflammatory cytokines.
Authors and Affiliations
Т. Д. Звягінцева, С. В. Глущенко
Keywords
Related Articles
- EP ID EP415392
- DOI -
- Views 145
- Downloads 0
СВІТЛОВІ ПРИЛАДИ ДЛЯ ОСВІТЛЕННЯ СПОРТИВНИХ МАЙДАНЧИКІВ
Increasing interest in sporting events by the mass of people and the development of telecommunication technologies led to increase in requirements for all engineering systems of sports facilities, including lighting syst...
ИННОВАЦИОННОЕ ПРИМЕНЕНИЕ LACERTA (ЛАЦЕРТА) ФАРМАЦЕВТИЧЕСКОЙ КОМПАНИИ «ЮРИЯ-ФАРМ» (УКРАИНА) В ТЕРАПЕВТИЧЕСКОЙ СТОМАТОЛОГИИ И ДЕНТАЛ-ФЕЙСЛИФТИНГЕ
The article describes the possibility of using the injection drug LACERTA, which in its composition has high molecular weight hyaluronic acid and succinate buffer of succinic acid, in therapeutic dentistry for the treatm...
ИЗМЕНЕНИЕ КРИСТАЛЛОГРАФИИ СЛЕЗЫ ПРИ ХОРИОРЕТИНАЛЬНОЙ ДИСТРОФИИ СЕТЧАТКИ
Authors have studied 24 cases with chorioretinal dystrophy of the retina. Of them 16 cases were with dry form of macular degeneration of the retina. All patients underwent crystallograms of tears. In this case, crystalli...
МОДЕЛЮВАННЯ СТРАТЕГІЧНОГО РОЗВИТКУ УНІВЕРСИТЕТІВ УКРАЇНИ В СИСТЕМІ УПРАВЛІННЯ ВИЩИМИ НАВЧАЛЬНИМИ ЗАКЛАДАМИ
The article reveals the problem of modelling of the university’s strategy development in the modern educational management. The author focuses the attention on the necessity of modelling of the university’s strategy deve...
ПРОЦЕСІЙНІ ХРЕСТИ І ПАТЕРИЦІ ЗАХІДНОЇ УКРАЇНИ XVII - XIX СТОЛІТТЯ: ТИПОЛОГІЯ, ІКОНОГРАФІЯ
In this publication, the author examines the iconographical representation of the processional attributes of the 17th – 19th centuries. The priority is given to the Christ plot. The author proposes the comparative charac...