INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES

INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES

Basic info

  • Publisher: CHANDRASEKHARA RAO BARU
  • Country of publisher: india
  • Date added to EuroPub: 2019/Sep/28

Subject and more

  • LCC Subject Category: Biological Sciences, Pharmaceutical science - Pharmaceutical science, Chemistry, Analytical Chemistry, Medicine
  • Publisher's keywords: Medicine, Pharmaceutical Sciences, Medicinal and Analytical Chemistry, Pharmacognosy, Hospital Pharmacy
  • Language of fulltext: english
  • Time from submission to publication: 4 weeks

Publication charges

  • Article Processing Charges (APCs): No
  • Submission charges: No
  • Waiver policy for charges? No

Open access & licensing

  • Type of License: CC BY-NC
  • License terms
  • Open Access Statement: Yes
  • Year open access content began: 2014
  • Does the author retain unrestricted copyright? False
  • Does the author retain publishing rights? False

Best practice polices

  • Permanent article identifier: DOI
  • Content digitally archived in: Nopolicy
  • Deposit policy registered in: None

This journal has '301' articles

ANALYSIS OF EFFECTIVENESS OF USE OF
BIORESORBABLE PLATES ON THE BASIS OF COLLAGEN
AND DIGESTASE FOR TREATMENT OF INFLAMMATORY
DISEASES OF PARODENTIUM IN ADOLESCENTS

ANALYSIS OF EFFECTIVENESS OF USE OF BIORESORBABLE PLATES ON THE BASIS OF COLLAGEN AND DIGESTASE FOR TREATMENT OF INFLAMMATORY DISEASES OF PARODENTIUM IN ADOLESCENTS

Authors: Sevbitov Andrei Vladimirovich1 , Timoshin Anton Vladimirovich 2 , Ergesheva Elena Valentinovna Sevbitov
Year: 2018, Volume: 5, Number: 1
(0 downloads)
Abstract

This article describes results of use of bioresorbable plates on the basis of collagen and digestase “Farmadont” as an anti-inflammatory drug being a part of a complex therapy for treatment of chronic generalized gingivitis in adolescents. Results of evaluation show a high effectiveness of use of the collagenic plates. Keywords: gingivitis, collagen, digestase, plates “Farmadont”, adolescents.

Keywords: gingivitis, collagen, digestase, plates “Farmadont”, adolescents.
ANTIMICROBIAL AND CYTOTOXIC ACTIVITIES OF PLANTDERIVED
ENDOPHYTIC METABOLITES FROM NORTHERN
BORDER REGION, KSA.

ANTIMICROBIAL AND CYTOTOXIC ACTIVITIES OF PLANTDERIVED ENDOPHYTIC METABOLITES FROM NORTHERN BORDER REGION, KSA.

Authors:
Year: 2018, Volume: 5, Number: 2
(0 downloads)
Abstract

Indigenous plants in Northern border region of Saudi Arabia are still virgins; the majority of them are still not markedly investigated for their phytoconstituents and/or their endophytic metabolites. The present work deals with the isolation, identification of endophytic fungal strains and investigation of their antimicrobial and cytotoxic activities from two indigenous plants, Polygonum aviculare and Achillea fragrantissima, three fungal strains have been isolated and identified as Pseudeurotium oval, Aspergillus sydowii, and Trichoderma longibrachiatum. These fungal strains were cultivated on solid nutrient media (rice media), their secondary metabolites were extracted and fractionated. The antimicrobial and Cytotoxic activities of these fractions were evaluated. Sub-fractions of both A. sydowii, and T. longibrachiatum showed a comparable antimicrobial activities while those of P. oval were inactive. In addition, Sub-fractions of both A. sydowii, and T. longibrachiatum showed a promising cytotoxic activities against three Mammalian cancer cell lines: MCF-7 cells (human breast cancer cell line), HepG-2 cells (human Hepatocellular carcinoma) and HCT-116 (colon carcinoma) while the most promising results obtained from T. longibrachiatum sub-fractions. Key words: Achillea fragrantissima, Polygonum aviculare, Pseudeurotium oval, Aspergillus sydowii, and Trichoderma longibrachiatum, Cytotoxic and antimicrobial activity

Keywords: Achillea fragrantissima, Polygonum aviculare, Pseudeurotium oval, Aspergillus sydowii, and Trichoderma longibrachiatum, Cytotoxic and antimicrobial activity
FORMULATION AND EVALUATION OF DILTIAZEM
CHRONOTHERAPETIC SYSTEMS BY PRESS COATING
TECHNOLOGY EMPLOYING MAGNESIUM STARCH- A NOVEL
TIMED-RELEASE POLYMER

FORMULATION AND EVALUATION OF DILTIAZEM CHRONOTHERAPETIC SYSTEMS BY PRESS COATING TECHNOLOGY EMPLOYING MAGNESIUM STARCH- A NOVEL TIMED-RELEASE POLYMER

Authors:
Year: 2018, Volume: 5, Number: 2
(0 downloads)
Abstract

The role of chronotherapeutics in hypertension management is based on the recognition that blood pressure does not remain constant throughout the day. Instead, it tends to be higher in the early morning hours and lower in the evening hours. The main objective of the present studies reported here was to investigate whether compression coating could be used to produce tablets providing maximum In-vitro drug release 8 to 10 hours after an evening dose taken at approximately 6:00 pm– 7.00 pm. The basic idea behind the dosage form development is to investigate effect of novel chronotherapeutic polymer i.e., magnesium starch and coating design on lag time and drug release from directly compressed time-controlled release tablet. The aim of the present study was to design time controlled tablet of Diltiazem hydrochloride, as chronopharmaceutical drug delivery system by press coating employing a novel chronotherapeutic polymer magnesium starch. Coating materials blend were evaluated for micromeritic properties like flow properties, compressibility index, Hausner’s ratio and also evaluated the tablet for hardness, thickness, friability and weight variation. The obtained results showed the capability of the system in delaying drug release for a programmable period of time to attain drug release after 10hours after an evening dose taken at according to a time-dependent approach. Key Words: Preparation, Diltiazem, Chronotherapeutic Systems, PressCoatingTechnology, Magnesium Strarch

Keywords: Preparation, Diltiazem, Chronotherapeutic Systems, PressCoatingTechnology, Magnesium Strarch
FORMULATION, EVALUATION AND OPTIMIZATION OF
FLOATING MATRIX TABLETS OF CARVEDILOL

FORMULATION, EVALUATION AND OPTIMIZATION OF FLOATING MATRIX TABLETS OF CARVEDILOL

Authors:
Year: 2018, Volume: 5, Number: 2
(0 downloads)
Abstract

Bilayer floating tablets were prepared by direct compression using HPMC K100M and Ethyl cellulose as the release controlling polymers and sodium bicarbonate as a gas generating agent. The optimum concentrations of the above ingredients were determined under experimental conditions and on the basis of trial batches of the tablets. In the present study bilayer tablet was prepared manually using single station punching machine. Accurately weighed 150mg of sustained release layer powder mixture was fed manually into die cavity. Sustained release layer was compressed at mild compression force (2-3 kg/cm2 ). After that accurately weighed 100mg of immediate release powder mixture was manually fed into the die over sustained release layer and compressed. Eleven formulations were prepared and evaluated for various evaluation parameters of bilayer tablet for physical properties, floating and in vitro drug release. All the formulations showed optimum flow properties, percentage of weight variation and friability. Accordingly, the increase of sodium bicarbonate from 0.5 to 9 % in the polymer resulted in a decrease in FLT from 9 to 1 min (F1-F3). Because of the amount of sodium bicarbonate also affected the drug release from the formulation, F2 have optimum concentration (4.5%) of sodium bicarbonate. The drug release pattern and drug uniformity were found to be satisfactory. Considering the in vitro drug release studies batch F9 was selected as optimized formulation Keywords: Bilayer floating matrix tablet, carvedilol, HPMCK100M, Sodium bicarbonate, sodium starch glycolate

Keywords: Bilayer floating matrix tablet, carvedilol, HPMCK100M, Sodium bicarbonate, sodium starch glycolate
PHYTOCHEMICAL ANALYSIS, CHEMICAL
CHARACTERIZATION AND ANTIOXIDANT ACTIVITY OF
HELICANTHUS ELASTICA DESR

PHYTOCHEMICAL ANALYSIS, CHEMICAL CHARACTERIZATION AND ANTIOXIDANT ACTIVITY OF HELICANTHUS ELASTICA DESR

Authors:
Year: 2018, Volume: 5, Number: 2
(0 downloads)
Abstract

The objective of present studies deals with the Phytochemical analsis, chemical characterization and antioxidant activity of Helicanthus elastica Desr. Total phenolic content, Total flavonoid content, Total proanthocyanidin content of ethyl acetate fraction was determined. Antioxidant activity was carried out by Nitric oxide scavanging activity, DPPH scavenging activity, reducing power assay and anti-lipid peroxidation activity. Characterization of ethyl acetate fraction of H.elastica carried out by LC-MS/MS method. The HPTLC together with LC-MS/MS study confirm the presence of quercetin and epicatechin in ethyl acetate extract. Quantitative studies reveal that plant contains higher amount of phenolics such as flavonoids and proanthocynidins. Antioxidant activity in various in vitro models demonstrated that extract have significant radical scavenging as well as antioxidant activity which is consistent with its higher flavonoid content. Key Words: Helicanthus elastica, ethyl acetate fraction, characterization, flavanoid, antioxidant

Keywords: Helicanthus elastica, ethyl acetate fraction, characterization, flavanoid, antioxidant
MOLECULAR BASIS OF HAIR LOSS-A MINI REVIEW

MOLECULAR BASIS OF HAIR LOSS-A MINI REVIEW

Authors:
Year: 2018, Volume: 5, Number: 2
(0 downloads)
Abstract

Molecular basis of the heredity hair loss has shown different types of mutations in different types of genes which are responsible for it among which of the major types of mutations includes Novel mutation, Recurrent Mutation and Splice Site mutation in following four genes that includes LIPH Gene on the chromosome number 3q26.3, G-protein coupled receptor (LPAR6/P2RY5) Gene the chromosome number 13q14.2, Desmoglein-4 (DSG4) gene at the chromosome number 8p21, Desmocollin (DSC3) genes, having locus on the chromosome number 18q12. These genes are mainly responsible for the Autosomal Recessive Heredity Hypotrichosis. While this point also cannot be ignored that Hypotrichosis also occurs in Autosomal Dominant form and some other types of genes are also discovered to be responsible for it that includes the KRT74 gene, which is responsible for the keratin k74 protein synthesis. Such genes are being found to be expressing themselves in the Human being’s hair follicles. Sequencing analysis of the KRT74 revealed heterozygous mutation c.422T4G (p. Phe141Cys) along the gene of K71 Keratin Initiation Helix Initiation encoded by KRT71 gene. Keywords: BASIS, Gene, Desmoglein-4 and Desmocollin

Keywords:
PREPARATION, OPTIMIZATION AND EVALUATION OF
MUCOADHESIVE MICROSPHERES OF LAMIVUDINE

PREPARATION, OPTIMIZATION AND EVALUATION OF MUCOADHESIVE MICROSPHERES OF LAMIVUDINE

Authors:
Year: 2018, Volume: 5, Number: 2
(0 downloads)
Abstract

Drug delivery systems [DDS] that can precisely control the release rates or target drugs to a specific body site have had an enormous impact on the health care system. Microspheres constitute an important part of these particulate DDS by virtue of their small size and efficient carrier characteristics. However, the success of these novel DDS is limited due to their short residence time at the site of absorption. It would, therefore, be advantageous to have means for providing an intimate contact of the DDS with absorbing membranes. Keywords: DDS, lamivudine, polymers, mucoadhesive, microspheres

Keywords: DDS, lamivudine, polymers, mucoadhesive, microspheres
ENHANCEMENT OF SOLUBILITY OF POORLY WATER
SOLUBLE LOVASTATIN DRUG BY SOLID DISPERSION
METHOD

ENHANCEMENT OF SOLUBILITY OF POORLY WATER SOLUBLE LOVASTATIN DRUG BY SOLID DISPERSION METHOD

Authors:
Year: 2018, Volume: 5, Number: 2
(0 downloads)
Abstract

Solid dispersions are one of the most promising strategies to improve the oral bioavailability of poorly water soluble drugs. By reducing drug particle size to the absolute minimum, and hence improving drug wettability, solubility increases hence bioavailability may be significantly improved. They are usually presented as amorphous products, mainly obtained by two major different methods, melting and solvent evaporation KeyWords: Hot melt extrusion, Hyperlipidemia, Povidone, Eudragit RL, Eudragit RS, polyethylene glycol (PEG), degree of porosity, Renex, Texafor AIP

Keywords: Hot melt extrusion, Hyperlipidemia, Povidone, Eudragit RL, Eudragit RS, polyethylene glycol (PEG), degree of porosity, Renex, Texafor AIP
DEVELOPMENT OF FENOFIBRIC ACID DELAYED RELEASE
PELLETS: OPTIMIZATION OF PROCESS VARIABLES IN
FLUID BED PROCESS

DEVELOPMENT OF FENOFIBRIC ACID DELAYED RELEASE PELLETS: OPTIMIZATION OF PROCESS VARIABLES IN FLUID BED PROCESS

Authors:
Year: 2018, Volume: 5, Number: 2
(0 downloads)
Abstract

The objective of the present study was to optimize the process of Fenofibric acid delayed release (DR) pellets. Wurster (Bottom spray fluid bed coating) process was employed to develop the Fenofibric acid DR pellets. This study assesses the impact of various process variables on drug layering by using statistical interpretation such as ANOVA. A face centered central composite design (CCD) was employed to study the effect of independent variables (product temperature, atomization air pressure, fluidization air volume and spray rate) on dependent variables (Fines, agglomerates, coating efficiency and assay). Fabricated pellets were characterized for various physico-chemical parameters and stability studies. Optimization was done by fitting experimental results to the software program (Design expert). The design space for process parameters and its influence on %fines, % agglomerates, coating efficiency and assay was developed. From the obtained results, 40°C ± 3°C as product temperature, 0.8 -1.2 kg/cm2 as atomization air pressure, 50 -65 cfm as fluidization air volume and 2-6 g/min as spray rate were selected as the operating ranges for robust coating process, desired yield and quality of the product. The drug release from the optimized formulation followed first order kinetics and controlled by non fickian transport. There is no significant change observed during stability. It was concluded that the face centered central composite design facilitated the process optimization of Fenofibric acid DR pellets. The Fenofibric acid DR pellets were successfully developed by employing bottom spray fluid bed coating (Wurster) technique. Key-Words: Fenofibric acid, Pellets, Fluid bed process, Process parameters, CCD.

Keywords: Fenofibric acid, Pellets, Fluid bed process, Process parameters, CCD.
EFFECT OF PROCESS VARIABLES ON COMPLEXATION OF
BITTER DRUG USING ION EXCHANGE RESINS

EFFECT OF PROCESS VARIABLES ON COMPLEXATION OF BITTER DRUG USING ION EXCHANGE RESINS

Authors:
Year: 2018, Volume: 5, Number: 2
(0 downloads)
Abstract

Donepezil Hydrochloride is a reversible inhibitor of the enzyme acetyl cholinesterase and used as an Alzheimer’s disease, but due to bitterness it has poor patient compliance. Strong and weak cation-exchange resins were used to block the functional group responsible for causing bitter taste by forming resinates of drug. An attempt was made to form drug-resin complexes of different ratios with various cation exchange resins like Indion-234, Indion-234, and Indion 254. Effect of variables was studied on percentage complexation of drug like type of process, time of complexation, time of swelling, temperature, activation media, pH, and concentration of loading solution and mode of complexation. Drug-resin complexes were characterized by DSC and FTIR study. Resinates of different ratios were subjected to sensory evaluation for taste by ranking method. Release of drug from each complex was studied at the pH of saliva (6.8) and at the gastric pH (1.2) to determine amount of the drug that would be released during the administration of formulation. Stability of drug-resin complexes was studied by carrying out AST at elevated temperatures. Amount of drug released from complex was about 5% at salivary pH and 95% at gastric pH.Drug: Indion-234 (1:3 w/w) complex showed good complexation. Drug-resin complex shows negligible decomplexation of resinate at salivary pH and maximum at gastric pH. Keywords: Taste Masking, IER, Drug-Resin Complex, SSF, SGF.

Keywords: Taste Masking, IER, Drug-Resin Complex, SSF, SGF.
SEPARATION AND QUANTIFICATION OF
PHARMACOLOGICALLY ACTIVE MARKERS p-METHOXY
BENZOIC ACID, 3, 4-DIHYDROXYBENZOIC ACID AND
GALLIC ACID FROM CAPPARIS SPINOSA AND FROM
MARKETED FORMULATION BY HPTLC

SEPARATION AND QUANTIFICATION OF PHARMACOLOGICALLY ACTIVE MARKERS p-METHOXY BENZOIC ACID, 3, 4-DIHYDROXYBENZOIC ACID AND GALLIC ACID FROM CAPPARIS SPINOSA AND FROM MARKETED FORMULATION BY HPTLC

Authors:
Year: 2018, Volume: 5, Number: 2
(0 downloads)
Abstract

A simple, accurate, precise and reproducible High Performance Thin Layer Chromatographic (HPTLC) method for simultaneous quantification of p-methoxybenzoic acid, 3, 4-dihydroxybenzoic acid and Gallic acid in the leaf extract of Capparis spinosa was developed. Chromatography was performed on silica gel 60 F254 pre-coated HPTLC plates with double development using two solvent systems. Using first solvent system, Chloroform: Ethyl acetate: Formic acid: Glacial acetic acid 7.5 : 2 : 0.5 : 0.5 (v/v/v/v) the plate was developed till 80 mm while the second development was carried out till 85 mm using Chloroform: Ethyl acetate: Formic acid: Glacial acetic acid 6 : 2 : 1 : 1 (v/v/v/v) as the mobile phase. After development the HPTLC plate was dried on a hot plate at 40° C for 5 min and scanned at 254 nm. The method was found to give well separated sharp bands of p-methoxybenzoic acid, 3,4-dihydroxybenzoic acid and gallic acid at Rf of 0.87, 0.66, 0.43 respectively. The quantity of p-methoxybenzoic acid, 3, 4- dihydroxybenzoic acid and gallic acid was found to be 0.00666 %, 0.02626 % and 0.01095 %; in plant and 0.01291 %, 0.02423 % and 0.06381 % in formulation respectively. The method was validated in terms of linearity, specificity, precision and recovery. Statistical analysis proved that the proposed method is accurate and reproducible. The developed method can be used as a quality control tool for simultaneous quantification of these markers from raw material as well as marketed formulation. Keywords: Capparis spinosa, p-methoxybenzoic acid, 3, 4-dihydroxybenzoic acid, Gallic acid, HPTLC, simultaneous quantification

Keywords: Capparis spinosa, p-methoxybenzoic acid, 3, 4-dihydroxybenzoic acid, Gallic acid, HPTLC, simultaneous quantification
A STUDY ON SYNERGESTIC WOUND HEALING ACTIVITY
OF CAPSICUM AND PIGEON PEA

A STUDY ON SYNERGESTIC WOUND HEALING ACTIVITY OF CAPSICUM AND PIGEON PEA

Authors:
Year: 2018, Volume: 5, Number: 2
(0 downloads)
Abstract

A study to investigate the use of aqueous extracts of poly herbs in promoting wound healing on experimentally induced open wound in albino rats was conducted. The wound healing activity of aqueous extract of the leaves from Cajanus cajan (AECc) and Capsicum annum (AECa), was evaluated by the rats of healing by wound concentration and period of epithelization at different days post- wound using the wound excision model. On day 9th, the mixture of AECc and AECa –treated animals exhibited significative reduction in the wound area than individual plant extracts when compared with standard drug silver sulphadiazine. Key Wards: Wound healing activity, plant extract, Excision wound model, Cajanus cajan, Capsicum annum

Keywords: Wound healing activity, plant extract, Excision wound model, Cajanus cajan, Capsicum annum
A BRIEF REVIEW ON WEGENER’S GRANULOMATOSIS AND
ITS TREATMENT

A BRIEF REVIEW ON WEGENER’S GRANULOMATOSIS AND ITS TREATMENT

Authors:
Year: 2018, Volume: 5, Number: 2
(0 downloads)
Abstract

Wegener's Granulomatosis (WG) which is otherwise called as Granulomatosis with polyangiitis (GPA) is an uncommon multi system autoimmune diseases, which is exceptionally connected with Anti-Neutrophil Cytoplasmic Antibodies (ANCA). Wegner's Granulomatosis is a complex multisystem vasculitic disease characterized by necrotizing small arteries and veins of unknown reason. In WG remission can be accomplished by regular immunosuppressive treatment. The causes of WG includes infectious and environmental triggers, drug induced ANCA-associated vasculitis (AAV) and also genetic factors. Staphylococcus aureus is a common micro-organism implicated in the pathogenesis of WG and the repeating, relapsing nature of the disease might be connected to steady colonization of nasal sections with this organism. Staphylococcus aureus creates super antigens which activate B and T Cells, and through a procedure of sub-atomic mimicry Staphylococcus aureus can likewise actuate AAV. The symptoms of WG include fevers, conjunctivitis, rhinitis, cough, myalgia, and necrosis. The diagnostic tests include ANCA testing, chest radiography, CT scanning, abnormal kidney function tests etc. Wegener’s granulomatosis affects various organs such as heart, eye, kidneys and lungs. Treatment of WG is considered to have two stages: induction, where active infection is put into remission; and support, where remission is managed. The backbone of treatment for WG is a mix of corticosteroids and cytotoxic agents. Keywords: Wegener’s granulomatosis, vasculitis, Anti-Neutrophil Cytoplasmic Antibodies, cyclophosphamide.

Keywords: Wegener's Granulomatosis (WG) which is otherwise called as Granulomatosis with polyangiitis (GPA) is an uncommon multi system autoimmune diseases, which is exceptionally connected with Anti-Neutrophil Cytoplasmic Antibodies (ANCA). Wegner's Granulomatosis is a complex multisystem vasculitic disease characterized by necrotizing small arteries and veins of unknown reason. In WG remission can be accomplished by regular immunosuppressive treatment. The causes of WG includes infectious and environmental triggers, drug induced ANCA-associated vasculitis (AAV) and also genetic factors. Staphylococcus aureus is a common micro-organism implicated in the pathogenesis of WG and the repeating, relapsing nature of the disease might be connected to steady colonization of nasal sections with this organism. Staphylococcus aureus creates super antigens which activate B and T Cells, and through a procedure of sub-atomic mimicry Staphylococcus aureus can likewise actuate AAV. The symptoms of WG include fevers, conjunctivitis, rhinitis, cough, myalgia, and necrosis. The diagnostic tests include ANCA testing, chest radiography, CT scanning, abnormal kidney function tests etc. Wegener’s granulomatosis affects various organs such as heart, eye, kidneys and lungs. Treatment of WG is considered to have two stages: induction, where active infection is put into remission; and support, where remission is managed. The backbone of treatment for WG is a mix of corticosteroids and cytotoxic agents. Keywords: Wegener’s granulomatosis, vasculitis, Anti-Neutrophil Cytoplasmic Antibodies, cyclophosphamide.
A SURVEY BASED STUDY TO ASSESS KNOWLEDGE ON FOOD
DRUG INTERACTIONS AMONG PHARMACY STUDENTS

A SURVEY BASED STUDY TO ASSESS KNOWLEDGE ON FOOD DRUG INTERACTIONS AMONG PHARMACY STUDENTS

Authors:
Year: 2018, Volume: 5, Number: 2
(0 downloads)
Abstract

Knowledge on food drug interactions is necessary to obtain complete therapeutic effect from the medication. Due to lack of awareness they are neglected though interactions may lead to undesired effects. A prospective questionnaire study comprising of 12 questions, each question have both right and wrong options was conducted among pharmacy students to assess their awareness about food drug interactions. The questionnaire was formatted in a simple and easy manner for the understanding of students. These forms are prepared in Google forms and circulated through whatsapp social media and the responses were collected. Total of 215 students participated in the study out of which 43.6% are males and 50.9% are females. Responses were evaluated using Microsoft excel. Most of the students are aware that alcohol is the major drink that causes interactions when taken along with the medication. Almost all the students are aware that milk should not be consumed with tetracyclines. The study also found that students had a limited awareness on food drug interactions. The study findings support the need for the students to update their knowledge through additional training and frequent patient counseling to improve therapeutic efficacy, drug compliance and safety of patients. Key words: Awareness, Food drug interactions, pharmacy students, questionnaire, therapeutic efficacy

Keywords: Awareness, Food drug interactions, pharmacy students, questionnaire, therapeutic efficacy
ELECTROCHEMICAL BIOSENSOR STUDIES OF
NITROKETENE DITHIOACETAL -METAL COMPLEXES

ELECTROCHEMICAL BIOSENSOR STUDIES OF NITROKETENE DITHIOACETAL -METAL COMPLEXES

Authors:
Year: 2018, Volume: 5, Number: 2
(0 downloads)
Abstract

Biosensors can be also divided into several categories based on the transduction process, such as electrochemical, optical, piezoelectric, and thermal/calorimetric biosensors. Among these various kinds of biosensors, electrochemical biosensors are a class of the most widespread, numerous and successfully commercialized devices of biomolecular electronics. Carbon and carbon based materials such as carbon nanotubes (single and multi-walled), graphene oxides, and fullerenes are good materials for various fields like battery applications, and biosensors due to their higher electrical conductivity, high mechanical strength, high surface area, thermal stability etc. On the other hand, conducting polymers have attracted behavior owing to their electrocatalytic activity and higher conductivity compared to those of carbon based materials. Among those conducting polymers, polyindole (PIn) is a great one with more advantages, such as its mechanical flexibility, light weight and low cost. Metal composites such as Mn2O3, Fe3O4, Ti2O3, Co3O4, NiO, and Cr2O3 have attracted fantastic attention in current years owing to their potential in environmental monitoring, sensor, drug delivery, photocatalysis, biomedical diagnosis, and energy storage applications These interesting properties revealed one of the greatest hopeful aspirants for their industrial applications. Among these metal oxides, Ti2O3 metal oxide have been commonly used in the invention of electrochemical biosensors, semiconductors, and in making electrical goods due to its large strong catalytic ability, adsorptive ability and surface area. Also it is cheaper than the traditional catalysts and these nanoparticles is easily incapacitating on the external of the metal electrodes, but secure them directly on the carbon electrode surface is quite difficult. The new metal ligand complex of NKDA-Metal(7) was the assynthesized NM has high dispersible property in water. The modified SPCE of NKDA – Zinc complex have electro-catalytic activity towards the detection of L-Met. The electrochemical behaviors of the NZ/SPCE were examined using cyclic voltammetry, and differential pulse voltammetry (DPV). The antibacterial activity of the complex was evaluated using Disc-Diffusion method. Key words: Metal-drug complexes, Electrochemical study, Biosensor, Nitroketene dithioacetal complex, antibacterial activity.

Keywords: Metal-drug complexes, Electrochemical study, Biosensor, Nitroketene dithioacetal complex, antibacterial activity.

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