Authors:
Sevbitov Andrei Vladimirovich1 , Timoshin Anton Vladimirovich 2 , Ergesheva Elena Valentinovna Sevbitov
Year: 2018,
Volume: 5,
Number: 1
(1 downloads)
Abstract
This article describes results of use of bioresorbable plates on the basis of collagen and digestase “Farmadont” as
an anti-inflammatory drug being a part of a complex therapy for treatment of chronic generalized gingivitis
in adolescents. Results of evaluation show a high effectiveness of use of the collagenic plates.
Keywords: gingivitis, collagen, digestase, plates “Farmadont”, adolescents.
Keywords: gingivitis, collagen, digestase, plates “Farmadont”, adolescents.
Authors:
Year: 2018,
Volume: 5,
Number: 2
(1 downloads)
Abstract
Indigenous plants in Northern border region of Saudi Arabia are still virgins; the majority of them are still not
markedly investigated for their phytoconstituents and/or their endophytic metabolites. The present work deals with
the isolation, identification of endophytic fungal strains and investigation of their antimicrobial and cytotoxic
activities from two indigenous plants, Polygonum aviculare and Achillea fragrantissima, three fungal strains have
been isolated and identified as Pseudeurotium oval, Aspergillus sydowii, and Trichoderma longibrachiatum. These
fungal strains were cultivated on solid nutrient media (rice media), their secondary metabolites were extracted and
fractionated. The antimicrobial and Cytotoxic activities of these fractions were evaluated. Sub-fractions of both A.
sydowii, and T. longibrachiatum showed a comparable antimicrobial activities while those of P. oval were inactive.
In addition, Sub-fractions of both A. sydowii, and T. longibrachiatum showed a promising cytotoxic activities
against three Mammalian cancer cell lines: MCF-7 cells (human breast cancer cell line), HepG-2 cells (human
Hepatocellular carcinoma) and HCT-116 (colon carcinoma) while the most promising results obtained from T.
longibrachiatum sub-fractions.
Key words: Achillea fragrantissima, Polygonum aviculare, Pseudeurotium oval, Aspergillus sydowii, and
Trichoderma longibrachiatum, Cytotoxic and antimicrobial activity
Keywords: Achillea fragrantissima, Polygonum aviculare, Pseudeurotium oval, Aspergillus sydowii, and Trichoderma longibrachiatum, Cytotoxic and antimicrobial activity
Authors:
Year: 2018,
Volume: 5,
Number: 2
(0 downloads)
Abstract
The role of chronotherapeutics in hypertension management is based on the recognition that blood pressure does
not remain constant throughout the day. Instead, it tends to be higher in the early morning hours and lower in the
evening hours. The main objective of the present studies reported here was to investigate whether
compression coating could be used to produce tablets providing maximum In-vitro drug release 8 to 10 hours
after an evening dose taken at approximately 6:00 pm– 7.00 pm. The basic idea behind the dosage form
development is to investigate effect of novel chronotherapeutic polymer i.e., magnesium starch and coating
design on lag time and drug release from directly compressed time-controlled release tablet. The aim of
the present study was to design time controlled tablet of Diltiazem hydrochloride, as chronopharmaceutical
drug delivery system by press coating employing a novel chronotherapeutic polymer magnesium starch. Coating
materials blend were evaluated for micromeritic properties like flow properties, compressibility index,
Hausner’s ratio and also evaluated the tablet for hardness, thickness, friability and weight variation. The obtained
results showed the capability of the system in delaying drug release for a programmable period of time to
attain drug release after 10hours after an evening dose taken at according to a time-dependent approach.
Key Words: Preparation, Diltiazem, Chronotherapeutic Systems, PressCoatingTechnology, Magnesium Strarch
Keywords: Preparation, Diltiazem, Chronotherapeutic Systems, PressCoatingTechnology, Magnesium Strarch
Authors:
Year: 2018,
Volume: 5,
Number: 2
(0 downloads)
Abstract
Bilayer floating tablets were prepared by direct compression using HPMC K100M and Ethyl cellulose as the release
controlling polymers and sodium bicarbonate as a gas generating agent. The optimum concentrations of the above
ingredients were determined under experimental conditions and on the basis of trial batches of the tablets. In the
present study bilayer tablet was prepared manually using single station punching machine. Accurately weighed 150mg
of sustained release layer powder mixture was fed manually into die cavity. Sustained release layer was compressed at
mild compression force (2-3 kg/cm2
). After that accurately weighed 100mg of immediate release powder mixture was
manually fed into the die over sustained release layer and compressed. Eleven formulations were prepared and
evaluated for various evaluation parameters of bilayer tablet for physical properties, floating and in vitro drug release.
All the formulations showed optimum flow properties, percentage of weight variation and friability. Accordingly, the
increase of sodium bicarbonate from 0.5 to 9 % in the polymer resulted in a decrease in FLT from 9 to 1 min (F1-F3).
Because of the amount of sodium bicarbonate also affected the drug release from the formulation, F2 have optimum
concentration (4.5%) of sodium bicarbonate. The drug release pattern and drug uniformity were found to be
satisfactory. Considering the in vitro drug release studies batch F9 was selected as optimized formulation
Keywords: Bilayer floating matrix tablet, carvedilol, HPMCK100M, Sodium bicarbonate, sodium starch glycolate
Keywords: Bilayer floating matrix tablet, carvedilol, HPMCK100M, Sodium bicarbonate, sodium starch glycolate
Authors:
Year: 2018,
Volume: 5,
Number: 2
(0 downloads)
Abstract
The objective of present studies deals with the Phytochemical analsis, chemical characterization and antioxidant
activity of Helicanthus elastica Desr. Total phenolic content, Total flavonoid content, Total proanthocyanidin
content of ethyl acetate fraction was determined. Antioxidant activity was carried out by Nitric oxide scavanging
activity, DPPH scavenging activity, reducing power assay and anti-lipid peroxidation activity. Characterization of
ethyl acetate fraction of H.elastica carried out by LC-MS/MS method. The HPTLC together with LC-MS/MS study
confirm the presence of quercetin and epicatechin in ethyl acetate extract. Quantitative studies reveal that plant
contains higher amount of phenolics such as flavonoids and proanthocynidins. Antioxidant activity in various in
vitro models demonstrated that extract have significant radical scavenging as well as antioxidant activity which is
consistent with its higher flavonoid content.
Key Words: Helicanthus elastica, ethyl acetate fraction, characterization, flavanoid, antioxidant
Keywords: Helicanthus elastica, ethyl acetate fraction, characterization, flavanoid, antioxidant
Authors:
Year: 2018,
Volume: 5,
Number: 2
(0 downloads)
Abstract
Molecular basis of the heredity hair loss has shown different types of mutations in different types of genes which are
responsible for it among which of the major types of mutations includes Novel mutation, Recurrent Mutation and
Splice Site mutation in following four genes that includes LIPH Gene on the chromosome number 3q26.3, G-protein
coupled receptor (LPAR6/P2RY5) Gene the chromosome number 13q14.2, Desmoglein-4 (DSG4) gene at the
chromosome number 8p21, Desmocollin (DSC3) genes, having locus on the chromosome number 18q12. These
genes are mainly responsible for the Autosomal Recessive Heredity Hypotrichosis. While this point also cannot be
ignored that Hypotrichosis also occurs in Autosomal Dominant form and some other types of genes are also
discovered to be responsible for it that includes the KRT74 gene, which is responsible for the keratin k74 protein
synthesis. Such genes are being found to be expressing themselves in the Human being’s hair follicles. Sequencing
analysis of the KRT74 revealed heterozygous mutation c.422T4G (p. Phe141Cys) along the gene of K71 Keratin
Initiation Helix Initiation encoded by KRT71 gene.
Keywords: BASIS, Gene, Desmoglein-4 and Desmocollin
Keywords:
Authors:
Year: 2018,
Volume: 5,
Number: 2
(0 downloads)
Abstract
Drug delivery systems [DDS] that can precisely control the release rates or target drugs to a specific body site have
had an enormous impact on the health care system. Microspheres constitute an important part of these particulate
DDS by virtue of their small size and efficient carrier characteristics. However, the success of these novel DDS is
limited due to their short residence time at the site of absorption. It would, therefore, be advantageous to have
means for providing an intimate contact of the DDS with absorbing membranes.
Keywords: DDS, lamivudine, polymers, mucoadhesive, microspheres
Keywords: DDS, lamivudine, polymers, mucoadhesive, microspheres
Authors:
Year: 2018,
Volume: 5,
Number: 2
(0 downloads)
Abstract
Solid dispersions are one of the most promising strategies to improve the oral bioavailability of poorly water
soluble drugs. By reducing drug particle size to the absolute minimum, and hence improving drug wettability,
solubility increases hence bioavailability may be significantly improved. They are usually presented as amorphous
products, mainly obtained by two major different methods, melting and solvent evaporation
KeyWords: Hot melt extrusion, Hyperlipidemia, Povidone, Eudragit RL, Eudragit RS, polyethylene glycol (PEG),
degree of porosity, Renex, Texafor AIP
Keywords: Hot melt extrusion, Hyperlipidemia, Povidone, Eudragit RL, Eudragit RS, polyethylene glycol (PEG), degree of porosity, Renex, Texafor AIP
Authors:
Year: 2018,
Volume: 5,
Number: 2
(0 downloads)
Abstract
The objective of the present study was to optimize the process of Fenofibric acid delayed release (DR) pellets. Wurster (Bottom
spray fluid bed coating) process was employed to develop the Fenofibric acid DR pellets. This study assesses the impact of
various process variables on drug layering by using statistical interpretation such as ANOVA. A face centered central composite
design (CCD) was employed to study the effect of independent variables (product temperature, atomization air pressure,
fluidization air volume and spray rate) on dependent variables (Fines, agglomerates, coating efficiency and assay). Fabricated
pellets were characterized for various physico-chemical parameters and stability studies. Optimization was done by fitting
experimental results to the software program (Design expert). The design space for process parameters and its influence on
%fines, % agglomerates, coating efficiency and assay was developed. From the obtained results, 40°C ± 3°C as product
temperature, 0.8 -1.2 kg/cm2 as atomization air pressure, 50 -65 cfm as fluidization air volume and 2-6 g/min as spray rate
were selected as the operating ranges for robust coating process, desired yield and quality of the product. The drug release from
the optimized formulation followed first order kinetics and controlled by non fickian transport. There is no significant change
observed during stability. It was concluded that the face centered central composite design facilitated the process optimization of
Fenofibric acid DR pellets. The Fenofibric acid DR pellets were successfully developed by employing bottom spray fluid bed
coating (Wurster) technique.
Key-Words: Fenofibric acid, Pellets, Fluid bed process, Process parameters, CCD.
Keywords: Fenofibric acid, Pellets, Fluid bed process, Process parameters, CCD.
Authors:
Year: 2018,
Volume: 5,
Number: 2
(0 downloads)
Abstract
Donepezil Hydrochloride is a reversible inhibitor of the enzyme acetyl cholinesterase and used as an Alzheimer’s
disease, but due to bitterness it has poor patient compliance. Strong and weak cation-exchange resins were used to
block the functional group responsible for causing bitter taste by forming resinates of drug.
An attempt was made to form drug-resin complexes of different ratios with various cation exchange resins like
Indion-234, Indion-234, and Indion 254. Effect of variables was studied on percentage complexation of drug like
type of process, time of complexation, time of swelling, temperature, activation media, pH, and concentration of
loading solution and mode of complexation. Drug-resin complexes were characterized by DSC and FTIR study.
Resinates of different ratios were subjected to sensory evaluation for taste by ranking method. Release of drug from
each complex was studied at the pH of saliva (6.8) and at the gastric pH (1.2) to determine amount of the drug that
would be released during the administration of formulation. Stability of drug-resin complexes was studied by
carrying out AST at elevated temperatures. Amount of drug released from complex was about 5% at salivary pH and
95% at gastric pH.Drug: Indion-234 (1:3 w/w) complex showed good complexation. Drug-resin complex shows
negligible decomplexation of resinate at salivary pH and maximum at gastric pH.
Keywords: Taste Masking, IER, Drug-Resin Complex, SSF, SGF.
Keywords: Taste Masking, IER, Drug-Resin Complex, SSF, SGF.
Authors:
Year: 2018,
Volume: 5,
Number: 2
(1 downloads)
Abstract
A simple, accurate, precise and reproducible High Performance Thin Layer Chromatographic (HPTLC) method for
simultaneous quantification of p-methoxybenzoic acid, 3, 4-dihydroxybenzoic acid and Gallic acid in the leaf extract
of Capparis spinosa was developed. Chromatography was performed on silica gel 60 F254 pre-coated HPTLC plates
with double development using two solvent systems. Using first solvent system, Chloroform: Ethyl acetate: Formic
acid: Glacial acetic acid 7.5 : 2 : 0.5 : 0.5 (v/v/v/v) the plate was developed till 80 mm while the second development
was carried out till 85 mm using Chloroform: Ethyl acetate: Formic acid: Glacial acetic acid 6 : 2 : 1 : 1 (v/v/v/v)
as the mobile phase. After development the HPTLC plate was dried on a hot plate at 40° C for 5 min and scanned at
254 nm. The method was found to give well separated sharp bands of p-methoxybenzoic acid, 3,4-dihydroxybenzoic
acid and gallic acid at Rf of 0.87, 0.66, 0.43 respectively. The quantity of p-methoxybenzoic acid, 3, 4-
dihydroxybenzoic acid and gallic acid was found to be 0.00666 %, 0.02626 % and 0.01095 %; in plant and 0.01291
%, 0.02423 % and 0.06381 % in formulation respectively. The method was validated in terms of linearity,
specificity, precision and recovery. Statistical analysis proved that the proposed method is accurate and
reproducible. The developed method can be used as a quality control tool for simultaneous quantification of these
markers from raw material as well as marketed formulation.
Keywords: Capparis spinosa, p-methoxybenzoic acid, 3, 4-dihydroxybenzoic acid, Gallic acid, HPTLC,
simultaneous quantification
Keywords: Capparis spinosa, p-methoxybenzoic acid, 3, 4-dihydroxybenzoic acid, Gallic acid, HPTLC, simultaneous quantification
Authors:
Year: 2018,
Volume: 5,
Number: 2
(0 downloads)
Abstract
A study to investigate the use of aqueous extracts of poly herbs in promoting wound healing on experimentally
induced open wound in albino rats was conducted. The wound healing activity of aqueous extract of the leaves from
Cajanus cajan (AECc) and Capsicum annum (AECa), was evaluated by the rats of healing by wound concentration
and period of epithelization at different days post- wound using the wound excision model. On day 9th, the mixture of
AECc and AECa –treated animals exhibited significative reduction in the wound area than individual plant extracts
when compared with standard drug silver sulphadiazine.
Key Wards: Wound healing activity, plant extract, Excision wound model, Cajanus cajan, Capsicum annum
Keywords: Wound healing activity, plant extract, Excision wound model, Cajanus cajan, Capsicum annum
Authors:
Year: 2018,
Volume: 5,
Number: 2
(0 downloads)
Abstract
Wegener's Granulomatosis (WG) which is otherwise called as Granulomatosis with polyangiitis (GPA) is an
uncommon multi system autoimmune diseases, which is exceptionally connected with Anti-Neutrophil Cytoplasmic
Antibodies (ANCA). Wegner's Granulomatosis is a complex multisystem vasculitic disease characterized by necrotizing
small arteries and veins of unknown reason. In WG remission can be accomplished by regular immunosuppressive
treatment. The causes of WG includes infectious and environmental triggers, drug induced ANCA-associated vasculitis
(AAV) and also genetic factors. Staphylococcus aureus is a common micro-organism implicated in the pathogenesis of
WG and the repeating, relapsing nature of the disease might be connected to steady colonization of nasal sections with
this organism. Staphylococcus aureus creates super antigens which activate B and T Cells, and through a procedure of
sub-atomic mimicry Staphylococcus aureus can likewise actuate AAV. The symptoms of WG include fevers,
conjunctivitis, rhinitis, cough, myalgia, and necrosis. The diagnostic tests include ANCA testing, chest radiography, CT
scanning, abnormal kidney function tests etc. Wegener’s granulomatosis affects various organs such as heart, eye,
kidneys and lungs. Treatment of WG is considered to have two stages: induction, where active infection is put into
remission; and support, where remission is managed. The backbone of treatment for WG is a mix of corticosteroids and
cytotoxic agents.
Keywords: Wegener’s granulomatosis, vasculitis, Anti-Neutrophil Cytoplasmic Antibodies, cyclophosphamide.
Keywords: Wegener's Granulomatosis (WG) which is otherwise called as Granulomatosis with polyangiitis (GPA) is an uncommon multi system autoimmune diseases, which is exceptionally connected with Anti-Neutrophil Cytoplasmic Antibodies (ANCA). Wegner's Granulomatosis is a complex multisystem vasculitic disease characterized by necrotizing small arteries and veins of unknown reason. In WG remission can be accomplished by regular immunosuppressive treatment. The causes of WG includes infectious and environmental triggers, drug induced ANCA-associated vasculitis (AAV) and also genetic factors. Staphylococcus aureus is a common micro-organism implicated in the pathogenesis of WG and the repeating, relapsing nature of the disease might be connected to steady colonization of nasal sections with this organism. Staphylococcus aureus creates super antigens which activate B and T Cells, and through a procedure of sub-atomic mimicry Staphylococcus aureus can likewise actuate AAV. The symptoms of WG include fevers, conjunctivitis, rhinitis, cough, myalgia, and necrosis. The diagnostic tests include ANCA testing, chest radiography, CT scanning, abnormal kidney function tests etc. Wegener’s granulomatosis affects various organs such as heart, eye, kidneys and lungs. Treatment of WG is considered to have two stages: induction, where active infection is put into remission; and support, where remission is managed. The backbone of treatment for WG is a mix of corticosteroids and cytotoxic agents. Keywords: Wegener’s granulomatosis, vasculitis, Anti-Neutrophil Cytoplasmic Antibodies, cyclophosphamide.
Authors:
Year: 2018,
Volume: 5,
Number: 2
(0 downloads)
Abstract
Knowledge on food drug interactions is necessary to obtain complete therapeutic effect from the medication. Due to
lack of awareness they are neglected though interactions may lead to undesired effects. A prospective questionnaire
study comprising of 12 questions, each question have both right and wrong options was conducted among pharmacy
students to assess their awareness about food drug interactions. The questionnaire was formatted in a simple and easy
manner for the understanding of students. These forms are prepared in Google forms and circulated through whatsapp
social media and the responses were collected. Total of 215 students participated in the study out of which 43.6% are
males and 50.9% are females. Responses were evaluated using Microsoft excel. Most of the students are aware that
alcohol is the major drink that causes interactions when taken along with the medication. Almost all the students are
aware that milk should not be consumed with tetracyclines. The study also found that students had a limited awareness
on food drug interactions. The study findings support the need for the students to update their knowledge through
additional training and frequent patient counseling to improve therapeutic efficacy, drug compliance and safety of
patients.
Key words: Awareness, Food drug interactions, pharmacy students, questionnaire, therapeutic efficacy
Keywords: Awareness, Food drug interactions, pharmacy students, questionnaire, therapeutic efficacy
Authors:
Year: 2018,
Volume: 5,
Number: 2
(0 downloads)
Abstract
Biosensors can be also divided into several categories based on the transduction process, such as electrochemical, optical,
piezoelectric, and thermal/calorimetric biosensors. Among these various kinds of biosensors, electrochemical biosensors are a
class of the most widespread, numerous and successfully commercialized devices of biomolecular electronics. Carbon and
carbon based materials such as carbon nanotubes (single and multi-walled), graphene oxides, and fullerenes are good materials
for various fields like battery applications, and biosensors due to their higher electrical conductivity, high mechanical strength,
high surface area, thermal stability etc. On the other hand, conducting polymers have attracted behavior owing to their
electrocatalytic activity and higher conductivity compared to those of carbon based materials. Among those conducting
polymers, polyindole (PIn) is a great one with more advantages, such as its mechanical flexibility, light weight and low cost.
Metal composites such as Mn2O3, Fe3O4, Ti2O3, Co3O4, NiO, and Cr2O3 have attracted fantastic attention in current years owing
to their potential in environmental monitoring, sensor, drug delivery, photocatalysis, biomedical diagnosis, and energy storage
applications These interesting properties revealed one of the greatest hopeful aspirants for their industrial applications. Among
these metal oxides, Ti2O3 metal oxide have been commonly used in the invention of electrochemical biosensors, semiconductors,
and in making electrical goods due to its large strong catalytic ability, adsorptive ability and surface area. Also it is cheaper
than the traditional catalysts and these nanoparticles is easily incapacitating on the external of the metal electrodes, but secure
them directly on the carbon electrode surface is quite difficult. The new metal ligand complex of NKDA-Metal(7) was the assynthesized
NM has high dispersible property in water. The modified SPCE of NKDA – Zinc complex have electro-catalytic
activity towards the detection of L-Met. The electrochemical behaviors of the NZ/SPCE were examined using cyclic voltammetry,
and differential pulse voltammetry (DPV). The antibacterial activity of the complex was evaluated using Disc-Diffusion method.
Key words: Metal-drug complexes, Electrochemical study, Biosensor, Nitroketene dithioacetal complex, antibacterial activity.
Keywords: Metal-drug complexes, Electrochemical study, Biosensor, Nitroketene dithioacetal complex, antibacterial activity.
