Ankara Üniversitesi Tıp Fakültesi Mecmuası

Ankara Üniversitesi Tıp Fakültesi Mecmuası

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  • Publisher: Galenos Yayinevi
  • Country of publisher: turkey
  • Date added to EuroPub: 2019/Nov/23

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This journal has '25' articles

Evaluation of Time and Color Perception in Children and Adults

Evaluation of Time and Color Perception in Children and Adults

Authors: Sertaç Üstün, Merve Akın, Furkan Atakan Akın, Serkan Tokgönül, Metehan Çiçek
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Abstract

Objectives: The study aimed to compare the time and color perception among adults and children to reveal the age-dependent change of the time perception. Materials and Methods: The children (n=30; age: 7-12, 50% female) and the adults (n=30, age: 20-25, 60% female) were selected randomly to participate to the study. To evaluate the time and color perception ‘‘Foreperiod Task’’ which was designed via MATLAB software was used. The percentage of correct responses and reaction times of participants were obtained to evaluate participants’ performance. Results: The percentage of correct responses and reaction times data were analyzed with two-way ANOVA separately. For the percentage of correct response; task effect (F=83.56, p<0.001), group effect (F=94.34, p<0.001) and task-group interaction (F=7.56, p<0.05) were significant. For the reaction time; group effect was significant (F=22.09 p<0.001). Task effect and interaction of task-group were not significant. Reaction times in time and color perception tasks were not different from each other both in adult groups and children groups (p>0.05). However, the percentage of correct responses for the two tasks differed significantly in both groups (for children: t=5.5, p<0.001; for adults: t=8.3, p<0.001). Conclusion: Performance score of the children was lower than adults in both tasks. Participants’ time perception performances were lower than their color perception and this performance difference was more distinct in children compared to adults. These results indicate that the development of time perception in children is slower than color perception. The fact that relatively complex neural networks are involved for the timing process in the brain might be the reason for the slow development of the time perception.

Keywords: Time Perception, Color Perception, Behavioral Experiment, Developmental Difference
Correlation Between the Kidney Volume and Body Parametres in Normal Adults

Correlation Between the Kidney Volume and Body Parametres in Normal Adults

Authors: Başak Gülpınar, Ayşegül Gürsoy Çoruh, Suat Kemal Aytaç
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Abstract

Objectives: Evaluation of kidney size and volume is very important in the diagnosis, treatment and follow-up of kidney diseases. Ultrasonography is the preferred imaging modality which provides a safe, reliable and affordable way of imaging the kidneys in the follow up of kidney diseases..In this study, we aimed to determine the kidney volume in normal adults and try to find out which of the physical features are more related with kidney volume. Materials and Methods: Between June 2005 and December 2008 177 patients referred for routine abdominopelvic ultrasonography (US) were included in the study. 16 patients who had renal masses, hydronephrosis and nephrolithiasis were excluded. Height, weight, body surface area (BSA) and body mass index (BMI) of the patients were recorded. Renal ultrasonography was performed and kidney sizes were evaluated in lateral decubitis position. Kidney sizes were measured on longitudinal and transverse scan. Ellipsoid formula was used to determine the kidney volume. Results: A total of 161 patients 69 (42,8%) male, 92 (57,5%) female were enrolled in the study. Mean kidney volume for right kidney was 125 mL and 134 mL for left kidney in women whereas it was 149 mL for right kidney and 155 mL for left kidney in men. There was a significant difference between right and left kidney volumes (p<0.05). Right and left kidney volume, right and left renal parenchymal thickness were ssignificantly higher in males than females (p<0.05). There was a positive correlation between kidney volume and height, weight, BMI and BSA Abstract but the strongest positive correlation was between height and kidney volume. Conclusion: Although kidney length is an important diagnostic marker for evaluating renal function; measurement of kidney lengtfh alone might not be sufficient. In cases where clinical and radiological residual renal capacity cannot be finalized, it is appropriate to calculate the renal volume. When evaluating the renal volume, it should be considered that the renal volume may differ depending on the body mass index, height, weight, BMI, and age.

Keywords: Kidney Volume, Ultrasonography, Weight, Height, Body Mass Index, Body Surface Area
Evaluation of Children Diagnosed with Acute Bacterial Sinusitis: Single-center Experience

Evaluation of Children Diagnosed with Acute Bacterial Sinusitis: Single-center Experience

Authors: Nisa Eda Çullas İlarslan, Fatih Günay, Emine Çiğdem Özer, Dilara Beşli Çelik, Esra Çakmak Taşkın, Halil Özdemir, Erdal İnce, Ergin Çiftçi
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Abstract

Objectives: Acute bacterial sinusitis (ABS) is among frequent infections in children. Its diagnosis is clinical unless a suspicion of complication exists. This study aimed to evaluate pediatricians’ clinical approaches to ABS. Materials and Methods: This retrospective study analyzed diagnosis, treatment and complication data of patients diagnosed with ABS between June 2015 and June 2018 in our pediatric primary care unit. Results: The study group consisted of 536 patients [female/male 235/301 (43.8%/56.2%)]. The median age was 6.6 (7 months-17.9 years) years. Median duration of symptoms was 7 (1-46) days. Major complaints were cough (n=379, 70.7%), nasal discharge (n=234, 43.7%) and fever (n=168, 31.3%). Among 468 patients with available data, persistent (>10 days) upper respiratory tract infection (URTI) was present in 198 (42.3%) while 8 (1.7%) had severe URTI. Worsening URTI data could not be defined because of inadequate records. Duration of symptoms was <3 days in 26 (16.2%) patients. Physical examination revealed postnasal discharge (n=393, 73.3%), frontal pain (n=26, 4.9%) and sinus tenderness when pressure was applied (n=25, 4.7%). Water’s paranasal sinus radiograph was performed in 38 (7.1%) patients. Most preferred antibiotics were amoxicillin-clavulanate 167 (78.4%), clarithromycin 18 (8.5%) and cefdinir 13 (6.1%). Symptomatic treatment was rarely prescribed [nasal decongestant (n=38, 17.8%), systemic antihistamines (n=23, 10.8%]. The median treatment period was 10 (3-30) days. Five patients (0.9%) were hospitalized for complications [preseptal cellulitis (n=4), frontal bone osteomyelitis and subdural abscess secondary to facial cellulitis (n=1)]. Patients with preseptal cellulitis were treated with parenteral ampicillin-sulbactam and the patient with osteomyelitis and abscess received ceftriaxone, vancomycin and metronidazole treatment following abscess drainage. Conclusion: Our results indicate that the diagnosis was substantially based on clinical evaluation even though complete compliance to clinical definitions recommended by current guidelines was lacking, and antibiotic treatment plans were often correct. Moreover, although rare, performance of further investigations and/or prescription of symptomatic treatment were observed. It was aimed to emphasize that clinicians should be encouraged for complete patient records and compliance to current guidelines.

Keywords: Acute Bacterial Sinusitis, Children, Current Guideline
Differentiation of Orbital Lesions with Diffusion Magnetic Resonance Imaging

Differentiation of Orbital Lesions with Diffusion Magnetic Resonance Imaging

Authors: Halis Harun Öztürk, Elif Peker, Başak Gülpınar, İlhan Memet Erden
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Abstract

Objectives: The aim of this study was to determinate the ADC values of different orbital masses and to calculate the threshold ADC value for differentiation of benign and malignant masses. Materials and Methods: For this study, ADC values of 43 lesions located in and around the orbita were measured. The obtained ADC values were averaged. Results: The mean age of the 43 patients included in the study was 49.3±16.6 (min-max= 17-76). Twenty-six (60%) of the patients were female and 17 (40%) were male. Forty-three lesions (28 benign and 15 malignant) were included in the study. The mean ADC values of benign lesions were 1304.8±636.2x10-6 mm2/s (min-max= 423-2709 x10-6 mm2/s), and the mean ADC values of malignant lesions were 785.6±264.1x10-6 mm2/s (min-max= 420-1357x10-6 mm2/s). The difference between the mean ADC values of benign and malignant lesions was statistically significant (p=0.006). The area under the curve in the ROC analysis was 0.776 (p=0.006). The cut-off value for malignancy was 841.25x10-6 mm2/s (sensitivity: 75%, specificity: 77%). No cystic area was observed in any of the malignant lesions. The mean ADC value of hemangiomas was significantly higher than meningiomas (1197.6±44.4 10-3 mm2/s vs 982.8±129.8 10-3 mm2/s; p=0.021). There was no statistically significant difference between ADC values obtained from leukemia/lymphoma involvement and abscesses (746±12.9 10-3 mm2/s vs 452.6±29.3 10-3 mm2/s, p=0.083). Conclusion: In the literature, the threshold value in the differentiation of benign and malignant lesions of the orbita is controversial. In our study, the sensitivity and specificity values were found to be low. Therefore, diffusion images should be correlated with clinical and other imaging findings.

Keywords: Orbita, Apparent Diffusion Coefficient, Diffusion, Magnetic Resonance
Hemispheric Differences in Brain Diffusion Values in 3 Tesla MR

Hemispheric Differences in Brain Diffusion Values in 3 Tesla MR

Authors: Elif Peker, Ayşegül Gürsoy Çoruh, Gürsoy Çoruh
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Abstract

Objectives: The purpose of this study is to demonstrate the variability of the diffusion values in different anatomical regions of the brain. Materials and Methods: 3T diffusion MR images of 190 patients underwent brain imaging were evaluated. Patients were divided into groups according to ages: 20-29, 30-39, 40-49, 50-59, 60-69. The ROIs were placed in the frontal, temporal, occipital, parietal lobes, cerebellum, thalamus, to be of equal size in both hemispheres. The ADC values obtained were standardized by dividing by the ADC values obtained from the ventricle. Results: One hundred and ninety patients, 97 men and 93 women, aged between 20 and 69 years, were included in the study. The mean ADC values were: frontal lobe=726,8x10-3 mm2/sec (532-945x10-3 mm2/sec), cerebellum=680x10-3 mm2/sec (586-816x10-3 mm2/(609- 996x10-3 mm2/sec) in the temporal lobe=791,2x10-3 mm2/sec (448-945x10-3 mm2/sec), parietal=789,9x10-3 mm2/sec (671-935 x10-3 mm2/sec) and in the occipital=790,6x10-3 mm2/sec (690-973x10-3 mm2/sec). Significant differences were found in the frontal, temporal lobes and cerebellum (p=0.600, p=0.430, p=0.227, respectively) in the thalamus, parietal and occipital lobes when the whole brain was evaluated. 0.011, p=0.000, p=0.000). There was a significant difference between all age groups for all lobes. When the frontal lobe, cerebellum, thalamus, temporal, parietal and occipital lobes were evaluated, the highest ADC values were obtained between ages 60-69 (748±44×10-3 mm2/sec, 689±34×10-3 mm2/sec, 731±41x10-3 mm2/sec, 827+41x10-3 mm2/sec, 809+56x10-3 mm2/sec, 821+56x10-3 mm2/sec). Conclusion: In different anatomical regions of brain, diffusion values are different.

Keywords: Diffusion Magnetic Resonance, Apparent Diffusion Coefficient, Hemispheric Differences
The Relationship Between the Tender Point Ultrasound Shear Wave Elastography Velocities and the Symptoms and Quality of Life in Fibromyalgia Syndrome

The Relationship Between the Tender Point Ultrasound Shear Wave Elastography Velocities and the Symptoms and Quality of Life in Fibromyalgia Syndrome

Authors: Aysun Genç, Uğur Kuş, Ali Ağuş, Hacı Musab Kıymaz, Onur Bozdağ, Yeşim Kurtaiş Aytür, Sehim Kutlay
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Abstract

Objectives: The primary objective of the study was to determine the potential tissue changes and ultrasound elastography flow rates at the sensitive points in patients with fibromyalgia syndrome and to obtain objective data; secondary aim is to determine the relationship between these flow rates and disease symptoms and quality of life and to determine the usefulness of these data in the follow-up of functional status and treatment of patients. Materials and Methods: Twenty-four female patients diagnosed as fibromyalgia syndrome with sensitive points in the upper trapezius and supraspinatus regions were questioned for morning stiffness, sleep quality, pain level (visual analog scale), mental status (Beck Depression Scale), functional status (Fibromyalgia Impact Questionnaire) and quality of life (SF-36). The ultrasound elastography flow velocities at the sensitive upper trapezoidal and supraspinatus points were measured with the Acuson S2000 ultrasound system (Siemens Medical Solutions, Mountain View, CA). All data were analysed statistically for correlation. Results: The mean age was 51.4 years (min-max=26-74). There was a positive correlation between ultrasound elastography flow rates and some SF-36 subscores and left trapezoidal neutral position and Visual Analogue Score (r=0.510, p=0.013). Conclusion: The data is not sufficient to use ultrasound elastography flow rates as a quantitative diagnostic criterion in fibromyalgia syndrome. Further studies involving enough sample size and including a control group will allow the questioning of the true value of the significant correlations that we find.

Keywords: Fibromyalgia Syndrome, Shear-wave Elastography, Quality of Life
Comparison of Mean Platelet Volume at Admission in Subtypes of Acute Myocardial Infarction

Comparison of Mean Platelet Volume at Admission in Subtypes of Acute Myocardial Infarction

Authors: Nil Özyüncü, Hüseyin Nazman, Cemre Tekin, Kerim Esenboğa, Turkan Seda Tan, Eralp Tutar
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Abstract

Objectives: Thrombus by the activated platelets and reduced blood flow of myocardium as a result of the thrombus lies under the pathophysiology of acute myocardial infarction (MI). Mean platelet volume (MPV) is known to increase by the activation and rapid turnover of the platelets. This parameter has been shown to increase in acute MI and high levels are associated with poor prognosis. Trials comparing the MPV in ST elevated and non-ST elevated myocardial infarction (MI) patients are so rare in the literature. We aimed to search for the difference in MPV in these 2 types of acute MI. Materials and Methods: We retrospectively searched for the patients followed up because of acute MI in our coronary intensive care unit. MPV was routinely worked up from the admission complete blood count analysis. Patients were compared in two groups as ST elevation MI and non-ST elevation MI. Results: As a result, 356 elligible patients were included in our trial (203 were non-ST elevation patients, 153 were ST elevation patients). Mean patient age was 63 and 29% were female. MPV in non-ST elevation group was significantly higher than ST elevation MI group (10.5±1.2 vs 10.1±1.2, p=0.001). Conclusion: We concluded that MPV, a parameter of platelet reactivity, was significantly higher in patients with non-ST elevated MI. Chronic underlying atherosclerosis, comorbidities and activated platelets probably playing more central role in pathophysiology of this acute MI type may explain these results. In non-ST elevation MI, urgent and appropriate antiaggregant therapy, as explained in the guidelines is as important as it is in ST elevated MI, we believe our results may be important for reminding this issue.

Keywords: Mean Platelet Volume, St Elevation Myocardial Infarction, Non-St Elevation Myocardial Infarction
Demographic and Clinical Characteristics of Ankara Haymana Thermal Center Applicants: A Cross-sectional Case Study

Demographic and Clinical Characteristics of Ankara Haymana Thermal Center Applicants: A Cross-sectional Case Study

Authors: Aysun Genç, Aslı Tok Özen, Birkan Sonel Tur
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Abstract

Objectives: Based on Ankara Haymana Thermal Centers, We questioned the availability of these data in the configuration of the centers by determining the purpose and manne r in which the balneotheraphy centers are used by the people of our country. Materials and Methods: In this descriptive study, a face-to-face questionnaire was applied to 110 people who came to the spa center for different reasons and accepted the study. Results: It is detected that of the 102 volunteers who completed the study, 63 were women and 39 were men. The mean age was 57,9±13,4 years (min-max:22-84), the average length was 163,8±8,1 cm (min-max: 145-183) and the mean weight was 77,1±12,5 kg (min-max: 40-109) 72.5% (n=74) of the volunteers had a diagnosis of musculoskeletal disorders and 34.3 (n=35) had a mean of 1.05±2.61 times (min-max:1-20) for various reasons. They stated that they received physical therapy in the centers for the treatment of their diseases and they did not receive balneotherapy. Volunteers come to the center with an average of 11.7±10.8 (min-max: 1-45) times, they enter the water 2±1.1 (min-max: 1-4) times a day and the average time they spend in the water is 36.5±26.6 min (min-max: 5-90 min). It was determined that 62.7 of the volunteers did not undergo a health check before coming to the center. Among the reasons for preference of the spa center, the most powerful indicator (n=76, 74.5 ) was determined as the healing of water. Conclusion: In order to analyze the reasons of patient preference and use it as an effective treatment method in the structuring and operation of the balneotherapy centers, it has shown that modern spa treatment principles should be implemented in an integrated way by applying the principles of modern spa treatment.

Keywords: SPA Treatment, Haymana SPA Centers, Balneotherapy
Effects of Hypothyroidism on Central and Peripheral Atherosclerosis in the Old Aged

Effects of Hypothyroidism on Central and Peripheral Atherosclerosis in the Old Aged

Authors: Volkan Atmış, Berna Evranos Öğmen, Murat Faik Erdoğan, Teslime Atlı
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Abstract

Objectives: Aging is associated with an increased incidence of thyroid function abnormalities. Thyroid hormones have been shown to affect vascular hemodynamics and arterial stiffness. Arterial stiffness appears to be an essential risk factor for cardiovascular disease. The long-term effect of hypothyroidism on the development of the peripheral arterial disease is not well understood. Pulse wave velocity (PWV) is a simple, non-invasive marker of atherosclerosis that measures arterial stiffness. Ankle brachial index (ABI) is a non-invasive technique commonly used to detect peripheral vascular diseases. A limited number of studies evaluated hypothyroidism as a risk factor for both peripheral arterial disease and arterial stiffness in the old aged. We aimed to investigate this relationship in older patients and then compared with their younger counterparts. Materials and Methods: A total of 22 patients ≥65 years of age and 23 younger patients with hypothyroidism and 23 gender-matched, and body mass index-matched old aged individuals with euthyroidism as controls were enrolled in this study. Old aged patients with hypothyroidism were defined as group I, old aged individuals with euthyroidism were defined as group II, and younger patients with hypothyroidism were defined as group III. PWV was measured between the carotid and femoral arteries. ABI was measured by a handheld Doppler. Results: PWV was similar (0.36) in older groups (groups I and II) and was lower (p < 0.001) in group III. ABI measurements (left and right) were similar in all groups (p > 0.05). More than half of the patients with hypothyroidism had subclinical hypothyroidism, and this condition was similar in all groups (p = 0.26). We also compared patients with hypothyroidism (group I plus III) with older controls with euthyroidism (group II). Median age was higher in group II than that in group I plus III (p < 0.001). PWV was higher in group II than that in group I plus III (p < 0.001). Hypertension was more common in group II than in group I plus III (p < 0.001). Conclusion: We did not find a relationship between hypothyroidism and atherosclerosis in old aged. PWV and hypertension were higher in older patients with hypothyroidism than in younger. Aging and hypertension increased PWV. Studies with larger series are needed to increase the reliability of these results.

Keywords: Hypothyroidism, Peripheral Arterial Disease, PWV, ABI, Arterial Stiffness, Old Aged
Hepatitis - HIV Seroprevalence and Immunization Rates Against Vaccine-preventable Diseases Among Trainee Nurses

Hepatitis - HIV Seroprevalence and Immunization Rates Against Vaccine-preventable Diseases Among Trainee Nurses

Authors: Ercan Yenilmez, Rıza Aytaç Çetinkaya
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Abstract

Objectives: To reveal the seroprevalence rates of hepatitis B, C and human immunodeficiency virus (HIV), and the immunization rates against hepatitis A, hepatitis B, measles, mumps, rubella, chickenpox and tetanus among trainee nurses, and also to interpret the results in guidance of literature. Materials and Methods: We searched the test results retrospectively of the nursing students who admitted to our hospital for traineeship between September and December 2018. Literature review was made by scanning the publications in the last 15 years (after 2003) in PubMed, Turk Medline and Google Scholar databases using the relevant keywords. Results: A total of 105 trainee nurses were included in the study. According to our results, no hepatitis B surface antigen positive cases were detected, and anti-hepatitis C virus (HCV) was positive in one case (0.9%) with negative HCV-RNA. Anti-HIV positivity was detected for the first time in a foreigner trainee nurse (0.9%). The antibody positivity rates for hepatitis-A, hepatitis-B, measles, rubella, mumps, varicella and tetanus were 26.4%, 81.8%, 70.6%, 92.7%, 86.5%, %95,8, 100%, respectively. Anti-HBs antibody levels were lower than 10 mIU/mL in 17 (17.3%) cases and between 11 and 50 mIU/mL in 17 (17.3%) cases. There were no cases with a tetanus antibody not detected, the number of cases with tetanus antibody levels between 0.01-0.5 IU/mL, 0.5-1 IU/mL, 1-5 IU/mL and >5 IU/mL were 4 (9.8%), 3 (7.3%), 25 (61%) and 9 (21.9%), respectively. Conclusion: Hepatitis-B and C seropositivity was very low; HIV positivity was detected for the first time in the screening of medical personnel in Turkey. Hepatitis-A seropositivity rates were low and showed a significant decrease compared to years. Low immunization rates reveal the necessity of screening the immunity of the health personnel against measles. Our results and the results of the similar studies support the necessity and the cost-effectiveness of vaccination and screening programs of health care professionals.

Keywords: Health Care Professional, Immunisation, Hepatitis, Measles, Seroprevalence
Long-term Follow-up Results of Patients with Percutaneous Endoscopic Gastrostomy and Factors Affecting Survival

Long-term Follow-up Results of Patients with Percutaneous Endoscopic Gastrostomy and Factors Affecting Survival

Authors: Evrim Kahramanoğlu Aksoy, Ferdane Sapmaz, Muhammet Akpınar, Zeynep Göktaş, Metın Uzman, Yaşar Nazlıgül
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Abstract

Objectives: Percutaneous endoscopic gastrostomy (PEG) is a minimally invasive procedure with well-known efficacy and safety that is frequently used in patients who cannot be fed orally. In the literature, studies investigating long-term follow-up results in patients undergoing PEG are limited. In this study, we aimed to determine the long-term follow-up results and the factors affecting mortality in patients undergoing PEG. Materials and Methods: Two hundred and three patients who underwent PEG placement between January 2013 and June 2018 were evaluated retrospectively. The demographic characteristics of the patients, postoperative follow-up times, complications, PEG indications, laboratory parameters during the procedure were recorded from the patient files. During the follow-up period, the mortality and time of the patients were determined via the death notification system. Results: A total of 203 patients (101 male, 102 female) were included in the study. The median age of the patients was 77 years (18-96). The most frequent PEG placement indication was stroke with a frequency of 34%, followed by dementia (28.6%), malignancy (10.8%) and other (15.8%) reasons. The median follow-up period was 33.6 months (30.5-36.7) and the median survival was 22 months [95% confidence interval (CI): 22.8-30.5]. Mortality rates were 1.5% in the first month, 3% in 3 months, 12.3% in 1 year, 26.6 years in 2 years, 34.5% in 3 years and 44.3% in 5 years. There was no correlation between PEG indications and mortality, but there was a statistically significant correlation between hyponatremia and mortality (Odds ratio: 1.07, p=0.027, %95 CI). Conclusion: There was no statistically significant relationship between PEG placement indications and mortality, but there was a statistically significant correlation between hyponatremia and mortality.

Keywords: Percutaneous Endoscopic Gastrostomy, Mortality, Follow-up Results
The Protective Effect of Coenzyme Q10 on the Renal Ischemia Reperfusion Induced Liver Injury

The Protective Effect of Coenzyme Q10 on the Renal Ischemia Reperfusion Induced Liver Injury

Authors: Aylin Akbulut, Buğra Bilge Keseroğlu, Gökhan Koca, Cem Nedim Yücetürk, Berat Cem Özgür, Hatice Sürer, Elmas Öğüş, Nihat Yumuşak, Jale Karakaya, Meliha...
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Abstract

Objectives: The aim of this study was to show the efficacy of coenzyme Q10, known as anti-oxidant with anti-inflammatory properties, in liver damage after renal ischemia-reperfusion (RIR). Materials and Methods: For this purpose, rats were divided into three groups to design an experimental RIR model. Group 1 rats were Sham group. Group 2 rats underwent RIR without any medication. Group 3 rats were given coenzyme Q10 before RIR. In order to evaluate the damage, serum urea, creatinine, aspartate aminotransferase (AST) and alanine aminotransferase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and gamma glutamyl transferase (GGT) levels were investigated and additionally tissue (MPO), malondialdehyde (MDA), total sulfhydryl (SH), total nitrite and myeloperoxidase (MPO) levels were investigated. Histopathologic examination was performed for all groups and DNA fragmentation resulting from apoptotic fragmentation was evaluated with caspase-3 and TUNEL with immunohistochemical methods. Results: Urea and creatinine levels and also ALP, ALT, AST, GGT and LDH levels were significantly increased in group 2 compared to the Sham group. These increases were significantly lower in group 3. The tissue levels of MDA, nitrite, and MPO were significantly increased in group 2 compared to the Sham group, and SH levels were significantly decreased in group 2. In the group 3 rats, MDA, nitrite and MPO levels were decreased when compared to group 2. Additionally there was a significant increase in histopathologic scores in group 2 compared to the Sham group, whereas the decrease in histopathologic scores of group 3 was found to be significant when compared to group 2. Similarly, caspase-3 and TUNEL scores were significantly high in group 2 compared to Sham group and the scores were significantly low in group 3 compared to group 2. Conclusion: Coenzyme Q10 improved the histopathological findings, the serum tests and tissue oxidative stress levels in post-RIR liver tissues. Our results show that coenzyme Q10 can play an important role in protection of liver against RIR-induced damage.

Keywords: Coenzyme Q10, Renal Ischemia-reperfusion, Distant Organ Injury, Anti-oxidant, Anti-inflammatory
Frequency of Vitamin D Deficiency in Postmenopausal Women Who Live in Ankara Region

Frequency of Vitamin D Deficiency in Postmenopausal Women Who Live in Ankara Region

Authors: Zeynep Kendi Çelebi, Berna İmge Aydoğan, Ali Uysal
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Abstract

Objectives: The aim of this study is to define the frequency of vitamin D deficiency in postmenopausal women and to evaluate its implications on bone metabolism. Patients, who admitted to the Ankara University Faculty of Medicine Outpatient Clinics included to the study. Materials and Methods: The study was conducted as a cross-sectional study. Postmenopausal women were scanned with DEXA and divided into three groups as osteoporosis, osteopenia, and the control group according to the T scores. During medical visit, patients’ clothing habits, and daily sunlight exposure rates have been scored from 1 to 4 with a questionnaire. Vitamin D, Parathyroid hormone (PTH), osteocalcin, Dependent personality disorder (DPD), calcium, phosphorus, Alkaline phosphotase (ALP) levels were compared. Results: 29.8% of the women had osteoporosis, and 45.8% had osteopenia. Forty eight women (36.6%) were reported to have severe vitamin D deficiency (25-OH-D<10 ng/mL), 38 women (%29) moderate vitamin D deficiency (10≤25-OH-D<20 ng/mL), and 22 women (%16.8) mild vitamin D deficiency (20≤25-OH-D<30 ng/mL). Only 23 of the women (17.6%) had vitamin D levels higher than 30 ng/mL. It was observed that as the vitamin D levels dropped, PTH levels increased. The threshold for 25-OH-D level was estimated as 16.3 ng/mL. A negative relation was observed between vitamin D and osteocalcin and a positive relation was observed between ALP, osteocalcin and PTH. Conclusion: Since the research to find out preventive effects of vitamin D on chronic diseases such as cancer, hypertension, diabetes mellitus and it is already known that vitamin D reduces the risk of falls and fracture, closer follow-up of patients with vitamin D levels below 16.3 ng/mL with appropriate vitamin replacement may be important in reducing bone loss.

Keywords: Postmenopausal Osteoporosis, Secondary Hyperparathyroidism, Vitamin D Deficiency
Factors Affecting Prognosis in Hypoxic Encephalopathy Patients Followed-up in Intensive Care Unit

Factors Affecting Prognosis in Hypoxic Encephalopathy Patients Followed-up in Intensive Care Unit

Authors: Nesrin Helvacı Yılmaz, Cem Erdoğan, Deniz Kızılaslan, Özge Arıcı Düz, Eren Toplutaş, Lütfü Hanoğlu
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Abstract

Objectives: Hypoxic encephalopathy (HE) after cardiac arrest is a clinical condition that can cause severe neurological sequelae and death. It is important to determine the prognosis in patients with HE for follow up and developing future treatments in the long term. Our aim was to investigate the effects of age, gender, hypothermia, lesion site in brain magnetic resonance imaging (MRI), seizure and electroencephalography (EEG) findings on prognosis in patients with the diagnosis of HE. Materials and Methods: The data of the adult intensive care unit was evaluated retrospectively. A total of 194 patients with HE were included into the study. One hundred and eighteen (60.8%) of the patients were male and 76 (39.2%) were female. The survivors and those who died were identified. Hypothermia therapy, brain MRI findings (cortical and/or subcortical lesion), presence of seizures (myoclonic, generalized, focal) and EEG findings (epileptic activity, status, generalized slowing) were recorded. Results: The mean age was 59.46±1.71 (18-89). Seventy-six (39.2%) patients underwent hypothermia. One hundred and seven (55.2%) patients died. The rate of exitus in elderly patients was significantly higher (p<0.01). The brain MRI of 88 patients showed hypoxic lesions (cortical in 8 patients, subcortical in 21 patients, cortical + subcortical lesion in 59 patients). The survival rate of the patients with cortical or subcortical pathology is significantly higher than patients with both pathology (p<0.01). As a result of multiple regression analysis, a 1-year increase in age, increased the risk of death by 4%, while the presence of pathological findings in both areas in brain MRI increased the risk of death by 2.62 times. There was no significant difference of gender, hypothermia, seizures and pathological EEG findings on survival (p>0.05). Conclusion: Approximately half of the patients included in our study died. The survival rate of the elderly patients and the patients with multiple lesions in brain MRI was low.

Keywords: Hypoxic Encephalopathy, Prognosis, Intensive Care Unit
The Effect of Narrow Band UVB and PUVA Treatment on Serum Folate Levels

The Effect of Narrow Band UVB and PUVA Treatment on Serum Folate Levels

Authors: Seçil Vural, Hilayda Karakök Güngör, Bengü Nisa Akay, Nihal Kundakçı
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Abstract

Objectives: Narrow band UVB (NBUVB) treatment is a preferred dermatological treatment modality especially in pregnant women because of high safety profile. Previous studies have shown photodegradation may decrease folate levels in blood. In this study we aim to investigate if phototherapy causes low folic acid levels in our patients. Materials and Methods: Patients applying to dermatology unit and receiving either psoralen plus UVA or NBUVB treatment with regular folic acid level check-ups were analysed retrospectively. Results: In none of the patients folic acid levels lower than reference levels were detected. Mean serum folate values in baseline were 9.30 (±3.22 SD). The mean value after 18 treatment sessions was 7.26 (±4.82 SD), and after 36 sessions was 8.69 (±3.6 SD). In PUVA group baseline mean folate level was 9.16 (±3.76 SD), followed by 6.76 (±4.89 SD) after 18 sessions and 9.41 (±3.79 SD) after 36 sessions. Repeated measure in time were not statistically significant in both groups (p>0.05). Conclusion: NBUVB and PUVA treatments appear to be safe in regards to blood folic acid levels in our population where Fitzpatrick skin type III and IV is more common.

Keywords: Narrow Band UVB, Psoralen and UVA, Serum Folate, Pregnant

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