AN ICE-CREAM TYPE PHARMACEUTICAL FORMULATION OF PIPERAZINE HYDRATE AND ITS EVALUATION
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2013, Vol 1, Issue 1
Abstract
The main objective of this work is to develop an ice cream type pharmaceutical formulation of piperazine hydrate and a process for preparing the same to substitute for tablets and syrups. Ice cream type formulations have merits over conventional formulae in-terms of compliance, so it can be used as an improved pharmaceutical formula for children affected by helminthic infection. The in-vitro diffusion profile of the formulation was studied in pH 1.5 buffer (acidic medium) and in pH 7.8 buffer (alkaline medium) for 2 hours in each buffer medium. The release in acid medium was 23.5% maximum at the end of 2 hours. This showed that only negligible amount of drug was released in acid medium. The release in pH 7.8 buffer was found to be 80% at the first 15mins which showed an immediate on-setting action of the drug in the body system. The drug release is prolonged up to 2 hours and absorption of up to 95% of the drug within 2 hours in the intestinal tract is possible. The diffusion study results concluded that major portion of the drug was available for the body system to cure the infection of Ascariasis.
Authors and Affiliations
M Komala, K Hima Bindu , P Shanmugapandiyan, P Veera Swamy, R Sivakumar,
Keywords
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