FORMULATION AND IN-VITRO EVALUATION OF ORNIDAZOLE GASTRORETENTIVE TABLETS BY USING LOW DENSITY SWELLABLE POLYMERS
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2013, Vol 1, Issue 5
Abstract
Gastro retentive drug delivery systems have shown to be of better significance in controlling release rate for drugs having site specific absorption. The present study was an attempt to develop floating tablets of ornidazole which on oral administration prolongs its gastric residence time there by increasing bioavailability. Ornidazole an oral antiprotozoal having narrow absorption window in the upper and lower part of gastrointestinal tract, floating matrix tablet using gas generating agent sodium bicarbonate and hydrophilic polymer Hydroxy propyl methyl cellulose by wet granulation technique. Preformulation studies were carried out to optimize the required quantity for HPMC K4M(10%), Eudragit(8%) was used. formulations were prepared using either HPMC k50, HPMC k100, HPMC k4, Xanthan gum, Ethyl cellulose with carbopol 934P. For F1 to F8 formulation HPMC concentration was increased to control the release of drug from the dosage form and for F11 formulation Eudragit concentration was increased to obtain viscosity. Fourier transform Infrared spectroscopy confirmed the absence of any drug/polymers/excipients interactions. F11 Formulations showed in-vitro buoyancy 9 hrs. The concentration of HPMC K4 was increased to control the release of drug from the dosage form for F11 , the concentration was increased for Eudragit to increase the binding nature . The cumulative % drug release of F11 formulation was found to be Ornidazole (92.8%) at the end of 9th hr. The formulation containing HPMC k4m and Eudragit showed better results compared to other formulated batches. Further Stability studies studies can be performed to ensure the efficacy of the formulated floating tabets.
Authors and Affiliations
Abeda Aqther, B. Pragati kumar, Peer Basha
Keywords
Related Articles
- EP ID EP33141
- DOI -
- Views 284
- Downloads 0
In-vitro antimicrobial efficacy of aqueous extract of Areca nut against Enterococcus faecalis
Background and Aim: Successful root canal therapy relies on the combination of proper instrumentation and effective irrigation of the root canal system. The aim of the study was to evaluate out the antibacterial efficac...
Efficacy and tolerability of corticosteroids in pediatric cancer chemotherapy patients
Efficacy and tolerability in the treatment of pediatric cancer was studied in the present investigation. Prednisone, Hydrocortisone, Dexamethasone, Prednisolone and Methyl prednisolone were used in the treatment. The p...
Antioxidant property for lipophilic extract of Strobilanthes kunthiana flowers
Strobilanthes kunthiana flowers are found on the hill slopes of the Western Ghats at an altitude of 6000 to 7000 feet. It is a bright blue bell shaped flower. The uniqueness of the flower is that it blooms once in 12 y...
An Assessment on RO water plants in Karimnagar District
Purity of drinking water plays vital role on people’s health. At present people are drinking the RO water from mineral plants. We have collected the samples various parts of the Karimnagar district. Majority of the min...
Evaluation of anti-diabetic and wound healing activities of 90% methanolic extract of Ficus mollis bark by using wistar strain rats
The anti-diabetic activity of the Methanolic extract of the bark of Ficus mollis(family: moraceae) was investigated on alloxan induced diabetic wistar rats. A comparison was made between both plant extract and a known...