Evaluation of anti-diabetic and wound healing activities of 90% methanolic extract of Ficus mollis bark by using wistar strain rats
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2014, Vol 2, Issue 1
Abstract
The anti-diabetic activity of the Methanolic extract of the bark of Ficus mollis(family: moraceae) was investigated on alloxan induced diabetic wistar rats. A comparison was made between both plant extract and a known antidiabetic drug glibenclamide (5mg/kg-1). The dried bark of Ficus mollis was subjected to extraction by continuous hot extraction method using methanol as a solvent. Phytochemical estimation was done for the presence of phytoconstituents. Dose selection was made on the basis of acute oral toxicity study (200mg/kg-1, 400mg/kg-1 bodyweight) as per OECD guidelines. Oral administration of extract of ficus mollis for 21days resulted in significant reduction in blood glucose level. Alloxan induced diabetic rat model and oral glucose tolerance test (OGTT) model was used for evaluation of antidiabetic activity.The biochemical parameters were analysed. All rats in the diabetic groups had FBG levels well within the diabetic range (>200 mg dL-1) at the initial stage of the experiment but after three weeks of treatment with extracts or glibenclamide the FBGL significantly dropped in dose-dependent manner, and also correct the lipid profile and liver enzymes. The results suggest that the Methanol extracts of the bark of Ficus mollis restored the metabolic changes in alloxan-induced diabetic rats. The wound healing activity of the Methanolic extract of the bark of Ficus mollis(family: moraceae) was investigated on alloxan induced diabetic wistar rats. A comparison was made between both plant extract and a known wound healind drug povidone iodine. For wound healing activity the bark of ficus mollis linn was powdered and then makes simple ointment base preparation. The ointment preparation was made in two concentrations 5% and 10% the wound healing effect was evaluated in control and alloxan induced diabetic rats, respectively. Povidone iodine is used as reference drug.
Authors and Affiliations
Jameeluddin M, Janarthan M, Duraivel S
Keywords
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