Resveratrol attenuates inflammation through tristetraprolin expression in human hepatocytes

Abstract

Resveratrol (Resv), a polyphenolic compound have the anti-inflammatory and antioxidant effects. Tristetraprolin (TTP) destabilizes mRNAs of pro-inflammatory cytokines. However, it was not clear how Resv exerts anti-inflammatory effects on hepatocytes. In this study, we used human hepatoma cell line (HepG2 cells) and analyzed samples using qRT-PCR. Resv increases TTP expression in hepatocytes. Resv attenuates LPS-induced inflammation through TTP expression in hepatocytes. In TTP deficient hepatocytes, LPS failed to attenuate TNFα, iNOS, and IL-6 mRNA expression whereas TTP level was still decreased. Our results suggest that Resv may attenuate inflammation in hepatocytes through TTP induction at least in part. This novel Resv-TTP signaling pathway provides new possibilities for the treatment of inflammatory diseases in liver.

Authors and Affiliations

Akhi Moni, Asif Iqbal, Md Jamal Uddin

Keywords

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  • EP ID EP36344
  • DOI -
  • Views 516
  • Downloads 0

How To Cite

Akhi Moni, Asif Iqbal, Md Jamal Uddin (2018). Resveratrol attenuates inflammation through tristetraprolin expression in human hepatocytes. Journal of Advanced Biotechnology and Experimental Therapeutics, 1(3), -. https://europub.co.uk/articles/-A-36344