Universal Journal of Pharmaceutical Research

Universal Journal of Pharmaceutical Research

Basic info

  • Publisher: Global Institute of Pharmaceutical Education and Research
  • Country of publisher: india
  • Date added to EuroPub: 2019/Feb/24

Subject and more

  • LCC Subject Category: Medicine
  • Publisher's keywords: Pharmaceutics, Pharmacology, Pharmaceutical Chemistry, Pharmacognosy and Phytochemistry, Biopharmaceutics, Pharmaceutical Analysis, Pharmaceutical Microbiology, Pharmaceutical Biotechnology, Pharmacology and Toxicology, Clinical Pharmacy, Bioinformatics, Pharmaceutical Management, Health Care Management, Hospital Management, Biochemistry, Regulatory Affairs
  • Language of fulltext: english
  • Full-text formats available: PDF

Publication charges

  • Article Processing Charges (APCs): Yes 100 USD
  • Submission charges: No
  • Waiver policy for charges? Yes

Editorial information

Open access & licensing

  • Type of License: CC BY
  • License terms
  • Open Access Statement: Yes
  • Year open access content began: 2016
  • Does the author retain unrestricted copyright? False
  • Does the author retain publishing rights? False

Best practice polices

  • Permanent article identifier: DOI
  • Content digitally archived in: Nopolicy
  • Deposit policy registered in: None

This journal has '151' articles

Message

Message

Authors: Prof. Dr. Kaijian Hou
Message 2019/Feb/24
( 0 downloads)
Abstract

The developments of new pharmaceuticals and novel methods of prevention, diagnosis and treatment of diseases would not be possible without significant advancement in pharmaceutical science and technology. The Universal Journal of Pharmaceutical Research (UJPR) aims to cover the outstanding developments in basic and translational research, ensuring its scientific priority and significance in the field of pharmaceutical science and technology. The Journal functions on principles of scientific excellence, publication ethics, and rapid dissemination of cutting edge research and innovation. We invite you to submit your most exciting work to the UJPR and to serve as reviewers when invited to do so. Reviewer engagement is one of the most important components in the pioneering, expedited, and fair review process to which the journal is committed to. We are very fortunate to have more than 100 editorial board members of more than 48 countries. We hope that in coming days many researchers and professors will join our team. UJPR board members will ensure the highest quality of the manuscripts accepted for publication through rigorous double blind peer review process, provided by the editors and a panel of strictly chosen experts in the field. Furthermore, the open access will provide UJPR considerable advantages over conventional journals of pharmaceutical sciences with greater visibility and impact. In coming yrs, we will achieve our target to add some new things, new concepts, to the available literature. Different articles published by UJPR will be beneficial and assist many researchers for their work. I congratulate all editorial board members of for their efforts and wish for the great success of “Universal Journal of Pharmaceutical Research”. I am delighted to announce the publication of the inaugural issue of the International, peer reviewed, open access UJPR on the behalf of the Editorial board. We are foreseeing a great success of the Journal in near future.

Keywords: Message
FORMULATION AND EVALUATION OF ETODOLAC NIOSOMES BY MODIFIED ETHER INJECTION TECHNIQUE

FORMULATION AND EVALUATION OF ETODOLAC NIOSOMES BY MODIFIED ETHER INJECTION TECHNIQUE

Authors: Ejiogu Deborah Chioma
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Abstract

Etodolac is an indole acetic acid derivative with half-life of 4 to 7 hrs. It is used for the treatment of Rheumatoid arthritis. Whenever used orally, it has many systemic side effects, so it is not preferred orally. In present study four niosomes formulations of Etodolac were successfully developed by modified ether injection technique using different nonionic surfactant i.e. Span 20, Span 40, Tween 20, Tween 40 and cholesterol. Formulations were evaluated for different parameters like particle size, entrapment efficiency, in-vitro release, stability studies.

Keywords: Etodolac, niosomes, surfactants, cholesterol, modified ether injection
ANTIFUNGAL, CYTOTOXIC AND PHYTOTOXICITY OF AERIAL PART OF RANUNCULUS MURICATUS

ANTIFUNGAL, CYTOTOXIC AND PHYTOTOXICITY OF AERIAL PART OF RANUNCULUS MURICATUS

Authors: Muhammad Shahzad Aslam, Rubina Rehman, Bashir A. Choudhary, Abdul Subhan Ijaz, Muhammad Uzair, Muhammad Syarhabil Ahmad
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Abstract

The present research is preliminary biological screening of aerial plant of Ranunculus muricatus (Ranunculaceae). Dichloromethane and methanol extracts of the aerial plant were investigated for their antifungal, phytotoxic and cytotoxic activities. Anti-fungal, cytotoxicity and phytotoxicity activities were performed by agar tube dilution assay, brine shrimp lethality bioassay and lemna bioassay respectively. Dichloromethane and methanolic extracts exhibited significant phytotoxicity against Lemna minor having Paraquat as standard drug and incubation condition (28±1ºC). None of extracts presented any significant cytotoxic activity having Imipenum and Etoposide as standard drug respectively. Both extract had nonsignificant antifungal activity but it has been noted that methanol extract showed 30% inhibition with linear growth at 70 mm, when compared with control; only against Microsporum canis. Ranunculus muricatus showed significant phytotoxicity. The phytotoxicty assay is a valuable major screen for weedicide investigation. Additionally, modern studies are currently carried out to identify the allelopathic constituents by isolation, purification and structure elucidation to find out as effective herbicidal.

Keywords: Biological screening; cytotoxicity, phytotoxicity, Ranunculus muricatus
FORMULATION AND IN-VITRO EVALUATION OF FLOATING MICROBALLOONS OF STAVUDINE

FORMULATION AND IN-VITRO EVALUATION OF FLOATING MICROBALLOONS OF STAVUDINE

Authors: Felix Sunday Yusuf
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Abstract

Objective of present study involves preparation and evaluation of floating microballoons of Stavudine. It is a potent antiviral agent, used for treatment of human immunodeficiency virus (HIV) infection. In present study Stavudine is used as a model drug, to increase its residence time in the stomach without contact with the mucosa. The microballoons were prepared by the emulsion solvent diffusion technique using different ratio of polymers (Eudragit S100, Ethyl cellulose and PVP K 30) as carriers. The yield of microballoons was up to 68.32-80.22 %. The cumulative percent drug release after 24 hrs of the Stavudine microballoons was in the range of 53.62 to 87.45 %.

Keywords: Stavudine, floating microballoons, floating drug delivery system
ROLE OF NON STEROIDAL ANTI-INFLAMMATORY DRUGS IN ACUTE UPPER GASTROINTESTINAL BLEEDING

ROLE OF NON STEROIDAL ANTI-INFLAMMATORY DRUGS IN ACUTE UPPER GASTROINTESTINAL BLEEDING

Authors: Soran Mohammed Gharib
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Abstract

Many patients presented to the causality with upper gastrointestinal bleeding, which is a serious condition associated with significant morbidity and mortality especially in elderly patients and those with coexisting medical diseases. The purpose of the study was to assess the general use of NSAIDs and their relation to upper gastrointestinal bleeding. Cross sectional study on patients who were referred for endoscopy for upper gastrointestinal bleeding in Sulaimany Teaching Hospital during the period from January to December 2016. All of them had been exposed to full history taking regarding age, gender, smoking, alcohol and medication used in addition to thorough physical examination and upper gastrointestinal endoscopic examination with biopsy when indicated. This study enrolled 100 patients with upper GIT bleeding and showed that 48% of those with upper GIT bleeding were using NSAIDs, with male to female ratio of approximately 2:1, and 37 patients (77.1%) of those who were taken NSAIDs, did not use PPI concomitantly. The study also revealed that elderly patients taking NSAIDs were at higher risk of developing upper GIT bleeding.

Keywords: NSAIDs, gastrointestinal bleeding
DEVELOPMENT AND EVALUATION OF MATRIX TYPE TRANSDERMAL PATCHES OF PIOGLITAZONE HYDROCHLORIDE

DEVELOPMENT AND EVALUATION OF MATRIX TYPE TRANSDERMAL PATCHES OF PIOGLITAZONE HYDROCHLORIDE

Authors: Dingwoke John Emeka Francis
( 0 downloads)
Abstract

In present study, different transdermal patches of Pioglitazone hydrochloride were prepared using different polymers and evaluated on many parameters. Locally fabricated Franz diffusion cell was used for the in-vitrorelease study. Result revealed that there is a direct relationship with weight of the patch and drug content. The thickness lies in the range of 0.027 to 0.038 mm. Average thickness was almost uniform within same formulation, a small variation in thickness was observed with different formulations. The weight of patches lies in the range of 43.31 to 46.3 mg. The percentage of the drug content lies in the range of 96.87 to 99.28. Content uniformity studies proved that the amount of Pioglitazone hydrochloride in each patch of 2.009 cm2 was found to be fairly uniform. Percent moisture absorption was found to be in the range of 4.388 to 5.465, largest in formulations of batch code T3 and least in the batch code T2.The prepared transdermal drug delivery system of Pioglitazone hydrochloride using different polymers such as HPMC, EC, Chitosan and PVP had shown good promising results for all the evaluated parameters. However, for the in-vitro drug release and drug content result, formulation T4 was shown to be the optimized formulation, as higher percentage of drug release was obtained.

Keywords: Pioglitazone hydrochloride, transdermal patches, in-vitro release
RIBAVIRIN LOADED ERYTHROCYTES BY ENDOCYTOSIS AS TARGETED DRUG CARRIER SYSTEM

RIBAVIRIN LOADED ERYTHROCYTES BY ENDOCYTOSIS AS TARGETED DRUG CARRIER SYSTEM

Authors: Walid Anwar Abdul-Raheem, Ayman Salama, Mohsen I Afouna, Ahmed M Samy
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Abstract

Loaded erythrocytes, as drug carrier system, has tremendous potential to carry outside specificity and sustained release of drug. Thereby, enhancing therapeutic index and minimize the dose and adverse effects as well as improvement patient compliance. In the present paper, erythrocytes loaded Ribavirin with the aim to benefit the reticulo endothelial system targeting potential of the carrier cells. Endocytosis technique was used for Ribavirin loading in erythrocytes and the entire loading procedure was evaluated and validated. The in-vitro release of carrier erythrocytes was characterized, as well as the hematological indices, osmotic fragility and SEM analysis. The maximum loaded amount and entrapment efficiency were found to be 9.58 ± 0.045 mg and 38.3% at 25mg/ml of Ribavirin concentration after 60 minutes incubation time at 37oC with 88.42% cell recovery. The in-vitro Ribavirin release was found to obey Higuchi diffusion kinetics. Hematological parameters of Ribavirin loaded erythrocytes were significantly differ from native erythrocytes at (p≤ 0.01). It was found that the mean corpuscular volume value was increased, while the mean corpuscular hemoglobin and the mean corpuscular hemoglobin content values were decreased. Also, the osmotic fragility behaviors of Ribavirin loaded erythrocytes were significantly decreased at (p≤ 0.001). The scanning electron microscope of Ribavirin loaded erythrocytes show obvious changes in the cell surface and morphology with rough cell surface and small lesions. The highly changed erythrocyte shape and morphology being one of the main determinants in erythrocytes disappearance kinetics in circulation, can be potentially beneficial in terms of successful cell targeting to the reticulo endothelial system which in turn leads to the improved Ribavirin effects on RES-mediated immune responses.

Keywords: Endocytosis, erythrocytes, osmotic fragility and scanning electron
EBOLA VIRUS DISEASE AND ITS COMPLICATIONS

EBOLA VIRUS DISEASE AND ITS COMPLICATIONS

Authors: Raj K Keservani, Anil K Sharma, Urmila Jarouliya, Amit Kumar Singh
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Abstract

In African countries Ebola virus has been responsible for several deaths. In addition to being a global health concern, the virus is also considered a potential biological threat. Ebola viruses are incompletely understood pathogens that cause severe, often fatal, illnesses in humans and non-human primates. Ebola virus disease affects most of the human being and finally mortality rate increases in that county. Most of the countries are on alert for the ebola virus because peoples have worked within the boundaries of the affected area of Africa. Such people are not permitted to enter in the resident country without proper test at airport or other places. In this review we have discussed ebola virus disease and it affects the peoples worldwide.

Keywords: Ebola virus, ebola virus disease (evd), hemorrhagic fever, filoviruses
RISING INCIDENCES OF PRODUCT RECALL

RISING INCIDENCES OF PRODUCT RECALL

Authors: Viney Chawla, Manish Pal Singh, Manish Kumar
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Abstract

There has been an increasing trend in the number of prescribed and over-the-counter drug recall over the last few years. The recall is usually due to company’s discovery, customer’s complaint or Food and Drug Administration (FDA) observation. The process of recall involves a planned specific course of action, which addresses the depth of recall, need for public warning, and the extent of effectiveness checks for the recall. Product recalls clashes thousands of companies every year affecting: sales, testing customer relationships and disrupting supply chains. Drug recall is incubus for pharmaceutical companies. It effects the reputation of the company. The reason for the recall can be divided into two categories: manufacturing related and safety/efficacy related. It is essential to follow all the guidelines related to drug development and manufacturing procedure so as to minimize drug recall.

Keywords: Drug product recall, guidelines, process, recall information
ALHAGI MAURORUM AND TAMARIX APHYLLA -TWO MEDICINAL WEEDS MENTIONED IN HOLY QURAN AND AHADITH AND THEIR ETHNOMEDICINAL USES IN DISTRICT RAJHANPUR OF PAKISTAN

ALHAGI MAURORUM AND TAMARIX APHYLLA -TWO MEDICINAL WEEDS MENTIONED IN HOLY QURAN AND AHADITH AND THEIR ETHNOMEDICINAL USES IN DISTRICT RAJHANPUR OF PAKISTAN

Authors: Muhammad Shahzad Aslam, Muhammad Syarhabil Ahmad
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Abstract

The present research work is based on two medicinal weeds: Alhagi maurorum and Tamarix aphylla (L.) mentioned in the 57 Ayat of Sura Al-Baqarah and 16 Ayat of Sura Saba in Holy Quran respectively. These plants were collected from Rajhanpur District, Punjab, Pakistan. The foremost purpose of this study is to document the knowledge of the ethnomedicinal significance of these plants in the light of Islam. An extensive and complete data was recorded. The comprehensive morphological character of these species was discussed. Botanical names, family, Quranic name, Arabic name, English name, Vernicular name, habit and habitat, distribution, parts used, medicinal uses are documented and references cited from Holy Quran, Ahadith.

Keywords: Ethnomedicinal study, Rajhanpur, Holy Quran and Ahadith
INVESTIGATION OF PRONIOSOMES GEL AS A PROMISING CARRIER FOR TRANSDERMAL DELIVERY OF GLIMEPIRIDE

INVESTIGATION OF PRONIOSOMES GEL AS A PROMISING CARRIER FOR TRANSDERMAL DELIVERY OF GLIMEPIRIDE

Authors: Hamdy Mohamed Dawaba, Elsaied Hamada Elsaied, Elsherbini Ahmed Ibrahim, Mohsen Ibrahim Afouna
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Abstract

The aim of the study was to develop a proniosomal carrier system that is capable of efficiently delivering entrapped glimepiride over an extended period of time for the treatment of type 2 diabetes. Proniosomal gels were developed based on Span 60 with and without cholesterol. The entrapment efficiency of drug inside niosomes developed from hydration of the proniosomes gel was also characterized. The in vitro release and skin permeation of glimepiride from various proniosomes gel formulations were investigated. The stability studies were performed at 4°C and at room temperature. The maximum entrapment efficiency was obtained when the cholesterol concentration was 10% of total lipid (90.02%). In vitro release through mixed Cellulose Ester membrane showed sustained release of drug from proniosomes gels. In vitro drug permeation across rabbit skin revealed improved drug permeation and higher transdermal flux with proniosomes gels compared to hydro-alcoholic gel of drug. Also, good physical stability was also achieved with proniosomes gels. Kinetics of in vitro skin permeation showed diffusion model of drug release from formulations. The study proved that the concentration of cholesterol had great influence on the properties of proniosomes gels. Hence, proniosomes preparation containing 10% cholesterol can significantly increase trans-epidermal flux and prolong the release of glimepiride.

Keywords: Cholesterol, glimepiride, proniosomes gel, span 60, sustained
ABACAVIR LOADED NANOPARTICLES: PREPARATION, PHYSICOCHEMICAL CHARACTERIZATION AND IN VITRO EVALUATION

ABACAVIR LOADED NANOPARTICLES: PREPARATION, PHYSICOCHEMICAL CHARACTERIZATION AND IN VITRO EVALUATION

Authors: Felix Sunday Yusuf, Yunus A A, Dingwoke Francis John, Udokwu Japheth Chigbo
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Abstract

The present study deals with the formulation and evaluation of Abacavir nanoparticles. Abacavir is an anti-retroviral drug; it is used in treatment of AIDS. Abacavir nanoparticles were formulated by solvent displacement method using Eudragit RL-100, chitosan and Poloxamer-188. Nanoparticles were characterized by determining its particle size, drug entrapment efficiency, particle morphological character and in-vitro drug release. Particle size range of nanoparticles was in the range of 121.4-140.6 nm. Zeta potential of formulations was determined, and it was found in range of 16.5-20.45 mv. The in-vitro release of nanoparticles were carried out which exhibited a sustained release of Abacavir from nanoparticles up to 10 hrs. The study concludes that nanoparticles can be a promising drug delivery system for sustained release of Abacavir in terms of increased bioavailability.

Keywords: Abacavir, nanoparticles, solvent displacement method, zeta
FORMULATION AND EVALUATION OF FINASTERIDE SUSTAINED-RELEASE MATRIX TABLETS USING DIFFERENT RATE CONTROLLING POLYMERS

FORMULATION AND EVALUATION OF FINASTERIDE SUSTAINED-RELEASE MATRIX TABLETS USING DIFFERENT RATE CONTROLLING POLYMERS

Authors: Igwe J. Chibueze, Emenike IV, Oduola A R
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Abstract

The aim of the present investigation was to develop oral controlled release matrix tablet formulations of Finasteride with different polymer ratios. Finasteride is chemically considered a synthetic 4-azasteroid drug. The granules were evaluated for angle of repose, bulk density and Compressibility index before being punched as tablets. The tablets were subjected to weight variation test, drug content, hardness, friability, and in vitro release studies. Observations of all formulations for physical characterization had shown that, all of them comply with the specifications of official pharmacopoeias and/or standard references. Different models for kinetic study were applied like zero order, first order, Higuchi, Hixson Crowell and Korsmeyer to study the release pattern and mechanism.

Keywords: Sustained release, matrix tablets, wet granulation
PREVALENCE OF DYSLIPIDEMIA AND ITS ASSOCIATION WITH DISEASE ACTIVITY IN PATIENTS WITH RHEUMATOID ARTHRITIS IN SULAIMANI GOVERNORATE

PREVALENCE OF DYSLIPIDEMIA AND ITS ASSOCIATION WITH DISEASE ACTIVITY IN PATIENTS WITH RHEUMATOID ARTHRITIS IN SULAIMANI GOVERNORATE

Authors: Soran Mohammed Gharib
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Abstract

Rheumatoid arthritis is a systemic inflammatory disease characterized by chronic and erosive polyarthritis it is the most common inflammatory arthritis, affecting from 0.5-1% of the general population. Dyslipidemia is a quite important problem in Rheumatoid arthritis (RA) patient, which causes morbidity and mortality. As known, dyslipidemia is one of atherosclerosis risk-factor, and main mortality cause of longstanding RA patient. Objectives are to measure Prevalence of dyslipidemia in patients with Rheumatoid Arthritis compared with healthy control peoples and to find out correlations between dyslipidemia and disease activity in patients with Rheumatoid Arthritis. A total of one hundred patients with RA (80 female and 20 male) were included in the study, they were attending consultation clinic and division of Rheumatology in the General Medical Teaching Hospital in Slemani city from (October 2015 to September 2016) who fulfilling the 2010 American College of Rheumatology/European league against Rheumatism classification criteria for RA and one hundred healthy age and sex-matched controls. Fasting lipid profiles of cases and control were estimated after an overnight fast of 12 hours. Association between lipid profile and disease activity using disease activity score DAS 28, inflammatory markers (CRP and ESR) was also determined. RA patients showed a higher prevalence of associated dyslipidemia (48%) in comparison to control (4%) p- value less than 0.001.Our result showed a significant reduction in serum high density lipoproteins (HDL) p-value less than 0.001, with significant elevation of serum total cholesterol, triglyceride, low density lipoprotein and very low density lipoprotein p-value 0.001, 0.007, 0.01and 0.5 respectively in comparison to controls. There is a significant association between dyslipidemia and high DAS 28 score (p=0.02). There is a significant association between high ESR of RA patients and dyslipidemia (p=0.001). A significant association was observed between high CRP level and RA patients with no dyslipidemia (p<0.001). Dyslipidemia are frequent among the patients with rheumatoid arthritis and highly associated with active RA. Serum HDL significantly reduced while other parameters of lipid profiles significantly increased in comparisons to control.

Keywords: Rheumatoid arthritis, dyslipidemia, disease activity
ANTI-INFLAMMATORY AND ANTI-OXIDANT ACTIVITIES OF METHANOL EXTRACT OF BAPHIA NITIDA

ANTI-INFLAMMATORY AND ANTI-OXIDANT ACTIVITIES OF METHANOL EXTRACT OF BAPHIA NITIDA

Authors: Deborah Ejiogu Chioma
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Abstract

Baphia nitida is a tropical plant used in African folkloric medicine for the treatment of infections and inflammatory conditions. This study therefore seeks to investigate the biological activities including antioxidant and anti-inflammatory properties of leaf and root methanol extracts of B. nitida. Anti-inflammatory activities of extract was investigated by the carrageenan-induced paw edema model of inflammation, respectively. The antioxidant properties of the extracts as determined by the DPPH free radical scavenging assay. The leaves and root extract demonstrated potent anti-inflammatory activity at low concentrations of between 25-75 mg/kg body weight.

Keywords: Baphia nitida, anti-oxidant, anti-inflammatory, carrageenan-induced paw edema

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