FORMULATION AND EVALUATION OF FINASTERIDE SUSTAINED-RELEASE MATRIX TABLETS USING DIFFERENT RATE CONTROLLING POLYMERS
Journal Title: Universal Journal of Pharmaceutical Research - Year 2016, Vol 1, Issue 2
The aim of the present investigation was to develop oral controlled release matrix tablet formulations of Finasteride with different polymer ratios. Finasteride is chemically considered a synthetic 4-azasteroid drug. The granules were evaluated for angle of repose, bulk density and Compressibility index before being punched as tablets. The tablets were subjected to weight variation test, drug content, hardness, friability, and in vitro release studies. Observations of all formulations for physical characterization had shown that, all of them comply with the specifications of official pharmacopoeias and/or standard references. Different models for kinetic study were applied like zero order, first order, Higuchi, Hixson Crowell and Korsmeyer to study the release pattern and mechanism.
Authors and Affiliations
Igwe J. Chibueze, Emenike IV, Oduola A R
PREVALENCE, ANTIMICROBIAL SUSCEPTIBILITY PATTERN AND RISK FACTORS OF MRSA ISOLATED FROM CLINICAL SPECIMENS AMONG MILITARY PATIENTS AT 48 MEDICAL COMPOUND IN SANA'A CITY-YEMEN
Methicillin-resistant strains of S. aureus evolved in the 1970 and have troubled hospitals worldwide with persistent infections in patients. The objectives of this study were to determine the prevalence, antimicrobial su...
Lozenges are the flavoured solid, unit dosage medicated dosage forms usually in the sweetened base intended to be sucked and held in the mouth or pharynx containing one or more medicaments. Lozenges were developed in 20...
Terbinafine is a broad spectrum antifungal drug. The aim of present study was to develop topical nano emulgel of terbinafine using carbopol 934 as a gelling agent. The objective behind the formulation was to avoid dosing...
PSEUDOMONAS AERUGINOSA SKIN-NASOPHARYNGEAL COLONIZATION IN THE IN-PATIENTS: PREVALENCE, RISK FACTORS AND ANTIBIOTIC RESISTANCE IN TERTIARY HOSPITALS IN SANA'A CITY -YEMEN
Pseudomonas aeruginosa is one of most important cause of healthcare-associated infections. This active surveillance cross sectional study was aimed to determine the rate of P. aeruginosa colonization among inpatients at...
At present scenario many researchers are working to develop technology that promises to deliver the drug in more efficient and less painful way in order to produce the therapeutic effects. Needle-free injection systems a...
How To Cite
Igwe J. Chibueze, Emenike IV, Oduola A R (2016). FORMULATION AND EVALUATION OF FINASTERIDE SUSTAINED-RELEASE MATRIX TABLETS USING DIFFERENT RATE CONTROLLING POLYMERS. Universal Journal of Pharmaceutical Research, 1(2), -. https://europub.co.uk/articles/-A-36367