QUALITY ASSESSMENT OF DIFFERENT BRANDS OF PARACETAMOL TABLETS IN YEMENI MARKET
Journal Title: Universal Journal of Pharmaceutical Research - Year 2018, Vol 3, Issue 4
Abstract
Paracetamol or acetaminophen is active metabolites of phenacitin. It is a widely used over-the-counter analgesic and antipyretic. Chemically, it is 4-hydroxy acetanilide (acetaminophen). Paracetamol is approved for reducing fever in people of all ages. It is commonly used for the relief of headaches, other minor aches and pains, and is a major ingredient in numerous cold and flu remedies. Many different brands and dosage forms of paracetamol are available in Yemeni market that places health practitioners in a dilemma of drug substitution in case of non-availability of a particular brand. The aim of the present study was to evaluate the quality control of four brands of paracetamol tablets (500 mg) marketed and commonly prescribed in Yemeni market. The results and findings of the present study will be interpreted and discussed. Four brands of paracetamol tablets (500 mg) were purchased from the retail pharmacy outlets and their pharmaceutical quality were assessed by using in-vitro tests according to USP and BP standards and unofficial standards as recommended by the manufacturers. The assessment of tablets included the evaluation of uniformity of weight, hardens, friability, disintegration time, dissolution test as well as assay content by UV spectrophotometric method. All brands passed USP and BP standards in- vitro quality control tests prescribed for the tablets except hardens test but all products were satisfactory for hardness. The results indicated that the overall quality of all tested paracetamol tablets brands was satisfactory as they met the requirements of the official and unofficial quality control tests.
Authors and Affiliations
Abdulmajed Alsaifi, Ali Alyahawi
Keywords
Related Articles
- EP ID EP36480
- DOI https://doi.org/10.22270/ujpr.v3i4.182
- Views 347
- Downloads 0
EBOLA VIRUS DISEASE AND ITS COMPLICATIONS
In African countries Ebola virus has been responsible for several deaths. In addition to being a global health concern, the virus is also considered a potential biological threat. Ebola viruses are incompletely understo...
A REVIEW ON GOLD NANOPRTICLES SYNTHESIS AND CHARACTERIZATION
Gold nano particles (GNP) have exceptional biocompatibility and possess unique structural, electronic, magnetic, optical, catalytic and molecular recognition properties. Hence GNPs are very attractive for many biological...
FORMULATION AND EVALUATION OF FINASTERIDE SUSTAINED-RELEASE MATRIX TABLETS USING DIFFERENT RATE CONTROLLING POLYMERS
The aim of the present investigation was to develop oral controlled release matrix tablet formulations of Finasteride with different polymer ratios. Finasteride is chemically considered a synthetic 4-azasteroid drug. The...
IN SILICO LIGAND-BASED 2D PHARMACOPHORE GENERATION FOR H+/K+ ATPASE INHIBITORS
At the beginning of the 20th century, Peptic Ulcer became the most prevalent disease as non-steroidal anti-inflammatory drugs (NSAIDs) proved ineffective. Researches proved proton pump inhibitors as most successful drugs...
ESTIMATION OF ANTI-INFLAMMATORY ACTIVITY AS WELL AS APOPTOTIC ACTIVITY OF ETHANOLIC EXTRACTS OF CROCUS SATIVUS
Inflammation is a body reaction which embroils cellular and biochemical responses, which is not only symptom for shared diseases but also known to be an initial phase for certain serious Alzheimer’s, cancer, heart vascul...