FORMULATION AND IN-VITRO EVALUATION OF FLOATING MICROBALLOONS OF STAVUDINE

Journal Title: Universal Journal of Pharmaceutical Research - Year 2016, Vol 1, Issue 1

Abstract

Objective of present study involves preparation and evaluation of floating microballoons of Stavudine. It is a potent antiviral agent, used for treatment of human immunodeficiency virus (HIV) infection. In present study Stavudine is used as a model drug, to increase its residence time in the stomach without contact with the mucosa. The microballoons were prepared by the emulsion solvent diffusion technique using different ratio of polymers (Eudragit S100, Ethyl cellulose and PVP K 30) as carriers. The yield of microballoons was up to 68.32-80.22 %. The cumulative percent drug release after 24 hrs of the Stavudine microballoons was in the range of 53.62 to 87.45 %.

Authors and Affiliations

Felix Sunday Yusuf

Keywords

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