Universal Journal of Pharmaceutical Research

Universal Journal of Pharmaceutical Research

Basic info

  • Publisher: Global Institute of Pharmaceutical Education and Research
  • Country of publisher: india
  • Date added to EuroPub: 2019/Feb/24

Subject and more

  • LCC Subject Category: Medicine
  • Publisher's keywords: Pharmaceutics, Pharmacology, Pharmaceutical Chemistry, Pharmacognosy and Phytochemistry, Biopharmaceutics, Pharmaceutical Analysis, Pharmaceutical Microbiology, Pharmaceutical Biotechnology, Pharmacology and Toxicology, Clinical Pharmacy, Bioinformatics, Pharmaceutical Management, Health Care Management, Hospital Management, Biochemistry, Regulatory Affairs
  • Language of fulltext: english
  • Full-text formats available: PDF

Publication charges

  • Article Processing Charges (APCs): Yes 100 USD
  • Submission charges: No
  • Waiver policy for charges? Yes

Editorial information

Open access & licensing

  • Type of License: CC BY
  • License terms
  • Open Access Statement: Yes
  • Year open access content began: 2016
  • Does the author retain unrestricted copyright? False
  • Does the author retain publishing rights? False

Best practice polices

  • Permanent article identifier: DOI
  • Content digitally archived in: Nopolicy
  • Deposit policy registered in: None

This journal has '151' articles

TABLET GRANULATION: CURRENT SCENARIO AND RECENT ADVANCES

TABLET GRANULATION: CURRENT SCENARIO AND RECENT ADVANCES

Authors: Bipin Kumar Verma, Savita Pandey, Priti Arya
( 0 downloads)
Abstract

Granulation is a size enlargement process, in fine or coarse particles converted into physically stronger and larger agglomerates having good flow property, better compression characteristics and uniformity, prevent segregation of the blend components, improve content uniformity, and eliminate excessive amounts of fine particles. Size of granules has a size range of 0.2 to 4.0 mm, depending on their subsequent use. Size of the granules depends on the quantity and feeding rate of granulating liquid. The selection of process to prepare granules requires thorough knowledge of physicochemical properties of the drug, excipients, required flow and release properties, to name a few. At current scenario available technologies includes, spray drying, roller compaction, high shear mixing, and fluid bed granulation etc. The objective of present work is to focus on the commonly used and novel granulation technologies like such as pneumatic dry granulation, steam granulation, moisture-activated dry granulation, thermal adhesion granulation, freeze granulation, and foamed binder or foam granulation.

Keywords: Granulation, content uniformity, moisture activated dry granulation technology, active pharmaceutical ingredients
A REVIEW OF BREAST CANCER RISK FACTORS

A REVIEW OF BREAST CANCER RISK FACTORS

Authors: Fakhsheena Anjum, Nighat Razvi, Amir Maqbool, Noor Jahan
( 0 downloads)
Abstract

Breast cancer is a commonly diagnosed neoplastic ailment in females particularly near menopause. This ailment signifies a substantial health problem as it has influenced a large number of women. Several risk factors are associated with breast cancer that cannot be altered, but certain can be modified. The existence of risk factors of breast carcinoma does not mean that cancer is unavoidable; numerous females having risk factors not ever developed the disease. The risk factors aid in identifying the females who may get help at maximum from screening or other precautionary measures. It is noteworthy that breast carcinoma can also ensue in females with no recognizable risk factors. The augmented occurrence of breast cancer worldwide revealed by several epidemiological investigations indicates the need of aiming multidirectional investigations so as to ascertain risk factors linked with the incidence of this disease.

Keywords: Cancer, breast cancer, incidence, occurrence, risk factors
LIQUISOLID TECHNIQUE FOR DISSOLUTION AND BIOAVAILABILITY ENHANCEMENT OF POORLY SOLUBLE DRUGS

LIQUISOLID TECHNIQUE FOR DISSOLUTION AND BIOAVAILABILITY ENHANCEMENT OF POORLY SOLUBLE DRUGS

Authors: Shrikant S. Magdum
( 0 downloads)
Abstract

Liquisolid formulations have attracted substantial interest as an efficient means of improving the dissolution and ultimately bioavailability. The technique is based upon the admixture of drug loaded solutions with appropriate carrier, coating materials and use of non-volatile solvent causes improved wettability. The inclusion complexes of drug with beta cyclodextrin (βCD) were formulated by kneading method and highest solubility complex was further used for preparation of liquisolid formulation to get synergistic effect. Also it raises drug incorporation with dissolution enhancement compared with conventional formulation. There are various techniques for bioavailability enhancement, such as altering the pharmacokinetic parameters, inhibition of enzyme etc. For this purpose some herbal inhibitors can be used; ex piperine. The prepared formulations were characterized by FTIR, DSC, PXRD and in vitro dissolution studies. Hence, this liquisolid technique with two way approach of solubility and bioavailability enhancement may found as key aspect in designing of formulations.

Keywords: Liquisolid, beta cyclodextrin, dissolution, bioavailability
SOLID DISPERSION- STRATEGY TO ENHANCE SOLUBILITY AND DISSOLUTION OF POORLY WATER SOLUBLE DRUGS

SOLID DISPERSION- STRATEGY TO ENHANCE SOLUBILITY AND DISSOLUTION OF POORLY WATER SOLUBLE DRUGS

Authors: Ankush Kumar, Kapil Kumar
( 0 downloads)
Abstract

Improving oral bioavailability of drugs those given as solid dosage forms remains a challenge for the formulation scientists due to solubility problems. Over the years a variety of solubilization techniques have been studied and widely used, as maximum drugs are poorly water soluble in pharmaceutical field. The enhancement of dissolution rate and oral bioavailability is one of the greatest challenges in the development of poorly water soluble drugs. Solid dispersions have attracted many researchers as an efficient means of improving the dissolution rate and hence the bioavailability of a range of poorly water-soluble drugs. The term solid dispersion refers to a group of solid products consisting of at least two different components, generally a hydrophilic inert carrier or matrix and a hydrophobic drug. Solid dispersion can form either a eutectic mixture or solid solution or glass solution or amorphous precipitation in a crystalline carrier or compound or complex formation. The focus of this review article is on the advantages, limitations, various methods of preparation and characterization of the solid dispersion.

Keywords: Solid dispersion, bioavailability, solubility, solubilization techniques, eutectic mixture
NEW ERA OF MEDICINE: ROLE OF NUTRACEUTICALS IN TREATMENT AND PREVENTION OF VARIOUS DISEASES

NEW ERA OF MEDICINE: ROLE OF NUTRACEUTICALS IN TREATMENT AND PREVENTION OF VARIOUS DISEASES

Authors: Oyeniran Taiwo O, Opeyemi Adegbenro, Ejiogu Deborah Chioma
( 0 downloads)
Abstract

Nutraceutical is a term coined to describe substances which are not traditionally recognized nutrients but which have positive physiological effects on the human body. Nutraceuticals are derived from various sources such as medicinal plants, marine organisms, vegetables and fruits. Since ancient times mankind has believed in the role played by the appropriate amount of nutrition in maintaining proper health. In the past few years the increasing interest is seen among the consumers, as they feel that it is a relatively safer way to good health. The potential of nutraceuticals/functional foods/food supplements in mitigating health problems. Nutraceuticals are alternative to modern medicine. Development of better characterized and research proven products will help enhance consumer confidence in nutraceuticals. In this review, an attempt has been made to discuss all aspects of nutraceuticals- definition, categories, classification their use in various diseases.

Keywords: Nutraceuticals, Dietary supplements, medicinal plants, health problems
RISK FACTORS OF PERIODONTAL DISEASES AMONG YEMENI YOUNG DENTAL PATIENTS

RISK FACTORS OF PERIODONTAL DISEASES AMONG YEMENI YOUNG DENTAL PATIENTS

Authors: Manal M. Al-Hajri, Abdoalbassed Mofudal, Alea A Al-Shami, Laila Al-Surihy, Nusaibe M. Ali
( 0 downloads)
Abstract

Periodontal diseasesare chronic infectious diseases that lead to the inflammation of specialized tissues that surround and support the teeth. Many risk factors and risk indicators, associated with increased risk of periodontal disease, have been identified. Gender, age, education, tooth brushing habit, smoking, khat chewing and shamaa use were associated with periodontal status in Yemen. Accordingly, the aim of our study is to assess the prevalence and related risk factors for periodontal diseases among Yemeni young dental patients in the faculty of dentistry Sanaa university.735 subjects (both males and females) and systemic free. Clinical examinations were performed including probing pocket depth, plaque index, gingival index and gingival recession. 110 Patients were less than 20 years and 9.1% healthy, 36.4% gingivitis, 22.7% generalized chronic periodontitis (GCP), 4.5% localized aggressive periodontitis (LAP), 27.3% generalized gingivitis with localized chronic periodontitis (LCP) and 0.0% generalized aggressive periodontitis (GAP). 625 Patients were more than 20 years and less than 29 years and 13.6% healthy, 8.7% gingivitis, 29.1% generalized chronic periodontitis (GCP), 2.7% localized aggressive periodontitis (LAP), 45.6% generalized gingivitis with localized chronic periodontitis (LCP) and 0.2% generalized aggressive periodontitis (GAP).Age, gender, education, tooth brushing habit, smoking, khat chewing and shamaa use habit were significantly (P ≤ 0.05) associated with periodontal status. The study confirmed various socio‑demographic risk factors/indictors associated with increased risk of periodontitis among Yemeni young dental patients.

Keywords: periodontal disease, prevalence, risk factors/indicators, khat
EPIDEMICITY OF VIBRIO CHOLERA IN SANA’A CITY, YEMEN: PREVALENCE AND POTENTIAL DETERMINANTS

EPIDEMICITY OF VIBRIO CHOLERA IN SANA’A CITY, YEMEN: PREVALENCE AND POTENTIAL DETERMINANTS

Authors: Ali Abdulkarim Sheiban, Hassan A. Al-Shamahy, Nashwan M. Alattab, Al-Kasem M. A. Abbas
( 0 downloads)
Abstract

In 2017, a total of 889854 suspected cholera cases with 2578 deaths were reported from Yemen, thus WHO considered these figures to be the worst epidemic of cholera in recent history of humanity. The aims of the study were to determine the prevalence of Vibrio cholera and protozoa causes in severe diarrhea patients and the potential risk factors of the contracting Vibrio cholera. Hospital-based diarrhoeal disease surveillance has been done for 12 days in Bany-alharth district of Sana'a city, where all patients admitted with severe diarrhoea in all health centers in the area were enrolled and tested for Vibrio cholerae, and others causes. The study was conducted on 345 patients and demographic, clinical, and potential risk factors were collected, then stool specimens were collected and processed by standard methods. The prevalence of V. cholerae was 8.1%, intestinal Entamoeba histolytica was 50.7%, and Giardia lamblia was 6.7% and one case of EPEC while 42% of diarrheal cases were undiagnosed. There was slightly increasing in the rate of V. cholerae infection with increasing age (15%). Also there were significant risk factors of dispose sewages to surround environment (OR=3.4 times, PV=0.02) and reused Jerry can bottles for drinking water (OR=3.1, PV= 0.03) with V.cholerae infection Vibrio cholera infection rate and intestinal protozoa infection rates were significantly high. The findings emphasize that there is cholera epidemic in Sana' city and diarrheal epidemic due to various diagnosed and non diagnosed pathogenic microorganisms which may predispose population of the study to significant health risks.

Keywords: Cholera; diarrhoea; prevalence; risk factors, Sana'a city, Saudi Aggression, Yemen
ANTIMICROBIAL ACTIVITIES FOR HADHRAMI HONEY ON GROWTH OF SOME PATHOGENIC BACTERIA

ANTIMICROBIAL ACTIVITIES FOR HADHRAMI HONEY ON GROWTH OF SOME PATHOGENIC BACTERIA

Authors: Ahmed M. Al-Haddad, Wedad M. Al-Haik, Ali Gamal Al-kaf, Wadhah Hassan Edrees
( 0 downloads)
Abstract

The majority of the Yemeni honey varieties are characterized by low moisture content, in addition to the various flora of Yemeni plant, which may not be found in many countries, which makes them of high medicinal importance and high monetary value. This study was carried out the effect of three types of Hadhrami honey: Somur, Sidr (Baghya) and Meria against the growth of some pathogenic bacteria (Pseudomonas aeruginosa, Proteus vulgaris, Escherichia coli, Enterobacter sp., Staphylococcus aureus, and Klebsiella sp.). The results revealed that that Sidr honey gave the highest antibacterial activity against all bacteria tested, whereas the Somur and Meria honey were not recorded activity for growth Klebsiella sp. and Meria honey was not recorded activity for growth E. coli, respectively. When the antibiotics compared to types of honey antimicrobial activity, it was observed that the antimicrobial effect of Sidr honey was better than Imipenem antibiotic effect against P. aeruginosa. The inhibition of the studied strains was dependent on the type of honey source. It is concluded that Yemeni honey could potentially be used as therapeutic agents against bacterial infection particularly to the tested microorganisms.

Keywords: antimicrobial activity of honey, Yemeni honey varieties, somur, sidr and meria
EFFECT AND MECHANISM OF TRADITIONAL CHINESE MEDICINE HUOLOU GUKANG PILL COMBINED WITH SIMVASTATIN ON STEROID-INDUCED NECROSIS OF FEMORAL HEAD

EFFECT AND MECHANISM OF TRADITIONAL CHINESE MEDICINE HUOLOU GUKANG PILL COMBINED WITH SIMVASTATIN ON STEROID-INDUCED NECROSIS OF FEMORAL HEAD

Authors: Qingfan Han, Dezhi Wang
( 0 downloads)
Abstract

Aim of present study was to explore the effect and mechanism of traditional Chinese medicine HuoLou Gukang pill combined with simvastatin on steroid-induced necrosis of femoral head. A total of 130 patients with steroid-induced necrosis of femoral head treated in our hospital from January 2016 to April 2017 were randomly divided into control group and study group. Each group had 65 cases. Control group were treated with simvastatin, patients in study group were treated with traditional Chinese medicine HuoLuo GuKang pill on the basis of control group. Before and after treatment, patients were tested for adiponectin, TNF-α, blood lipid and blood glucose. Harris score and VAS score were also measured. There was no significant difference in adiponectin, TNF-α, blood glucose, CH, TG, HDL-C and LDL-C between two groups before treatment (P>0.05). After treatment, the levels of adiponectin and HDL-C in study group were significantly higher than those in control group (P<0.05), but the levels of TNF-a, blood glucose, CH, TG and LDL-C in study group were significantly lower than those in control group (P<0.05). There was no significant difference in Harris score and VAS score between two groups before treatment (P>0.05). The Harris score of study group was significantly higher than that of control group after treatment (P<0.05). The VAS score of study group was significantly lower than that of control group (P<0.05). After follow-up comparative analysis, there was no significant difference between Harris score and VAS score in study group (P>0.05), but there was significant difference in control group (P<0.05). The efficacy of two groups was analyzed based on Harris scores: The total effective rate was 96.9% in study group and 86.2% in control group (P<0.05). The efficacy of two groups was analyzed based on VAS scores: The total effective rate of study group was 95.4%, significantly higher than that of control group (84.6%), and the difference was statistically significant (P<0.05).The treatment effect of Chinese medicine HuoLou Gukang pill combined with simvastatin on steroid-induced necrosis of femoral head is better than that of simvastatin. Chinese medicine HuoLou Gukang pills combined with simvastatin can intervene the development of steroid-induced necrosis of femoral head effectively, prevent malignant progress and reduce incidence of patients by reducing blood lipid and improving hemodynamic mechanism, thus it is worthy being popularized and applied.

Keywords: Simvastatin, HuoLou Gukang pills, steroid-induced necrosis of femoral head, treatment, mechanism
HOW DO VITAMIN AND PLANT SEEDS WORK AS HYPOLIPIDEMIC AGENTS ?

HOW DO VITAMIN AND PLANT SEEDS WORK AS HYPOLIPIDEMIC AGENTS ?

Authors: Shah Murad, Azmat Ali, Hina Aslam, Khalid Niaz
( 0 downloads)
Abstract

Cardiovascular diseases are leading cause of death in western and eastern countries of the world. Hyperlipidemia is one of the strong risk fractions for heart diseases. To evaluate hypolipidemic drugs efficacy, the study was conducted at National hospital, Lahore Pakistan from January 2016 to August 2016. Ninty hyperlipidemic patients were selected from cardiology and medical wards of the hospital. They were divided in three groups, one at placebo therapy, another on Kalonji and third one on Vitamin B3. After one and half month, significant changes (p value ranging from <0.05 to <0.001) were observed in their LDL and HDL-cholesterol. Conclusion of the study was to recommend use of herbal medicine and vitamin B3 for prevention of any heart diseases with good patient compliance.

Keywords: Cardiovascular diseases, Hyperlipidemia, vitamin and Kalonji
THE ASSOCIATION OF ADULT MALE AND FEMALE INFERTILITY WITH CELIAC DISEASE PATIENTS IN YEMEN

THE ASSOCIATION OF ADULT MALE AND FEMALE INFERTILITY WITH CELIAC DISEASE PATIENTS IN YEMEN

Authors: Al-Anesi Mohsen, Qiping Hu, Ekram Al-Eryani, Mansour Al-Amrani, Hassan Al-Shamahy
( 0 downloads)
Abstract

Celiac disease’s potentially destructive effect on reproductive health is among the most vital matters associated with progress awareness. Men and women with unexplained infertility, women with recurrent abortions, intrauterine growth retardation, low birth weight babies and menstrual disorders are not often screened for celiac disease (CD) despite scientific studies that point to a correlation. The aims of the present study were to examine the evidence of the correlation between CD and infertility by measuring sex hormones in CD comparing healthy controls (HC).The study was carried out in Autoimmune Unit, AL-Thowra Hospital Sana’a city, Yemen. The study included 32 CD patients, and 32 HC. Blood samples were collected then examined for sex hormones in both. There was highly significant low down level of the mean ± SD of sex hormones among male and female CD than HC: for male CD FSH=1.96±1.4 IU/ml vs 3.3±1.27 IU/ml of HC, LH=3.9±3.3 IU/ml vs 6.5±2.03 IU/ml of HC; and the testosterone=1.03±0.76 IU/ml, vs 3.8±1.4 IU/ml of HC. For CD females the mean ± SD of FSH, for CD females was 4.37±2.46 IU/ml vs 4.92±2.35 IU/ml of HC, Estradiol (40.7±30.8 IU/ml vs 7.1±76.66 IU/ml of HC), and Progestrone (1.2±1.15 IU/ml, vs 6.4±4.38 IU/ml of HC). In conclusion, there was significant association between CD and infertility among Yemeni CD patients in which it indicated by low sex hormones in CD patients.

Keywords: Celiac disease, infertility, sex hormones, Sana’a, Yemen
EXTRACTION AND PHYSICOCHEMICAL CHARACTERIZATION OF NOVEL POTENT MUCOADHESIVE BIO-MATERIAL OBTAINED FROM THE FRESH FRUITS PULP OF ACHRAS ZAPOTILLA

EXTRACTION AND PHYSICOCHEMICAL CHARACTERIZATION OF NOVEL POTENT MUCOADHESIVE BIO-MATERIAL OBTAINED FROM THE FRESH FRUITS PULP OF ACHRAS ZAPOTILLA

Authors: Arun Kumar Singh, Anita Singh, N.V Satheesh Madhv
( 0 downloads)
Abstract

The objective of present investigation was to isolate an effective novel mucoadhesive biomaterial from the pulp of Achras Zapotilla, belonging to Sapotaceae family. In the recent years the research in the biomaterial isolation and their use as pharmaceutical excipient become a core area for formulation scientist to develop safe and effective drug delivery system. The biomaterial was isolated by simplified economical method and was subjected to phytochemical, physicochemical, micromeritic as well as spectral analyses like IR, 1HNMR, DSC, SEM and Elemental analysis. The mucoadhesive property of the biomaterial was assessed by shear stress method, falling sphere method and rotating cylinder method using nasal mucosa as substrates. The results were compared with HPMC and sodium CMC as a standard. The formation of hydrogen bond by natural mucoadhesive agent with mucosa was confirmed by FTIR spectra showing carboxyl and hydroxyl groups. The research study revealed that the biomaterial obtained from fruit pulp of Acarus zapotila exhibited a promising potent natural mucoadhesive property and may be used to develop mucoadhesive transmucosal drug delivery systems.

Keywords: Nasal Mucosa, mucoadhesive property, shear stress testing, achras zapotilla, x-ray diffraction spectroscopy, thermal analysis
BIODEGRADATION OF PARACETAMOL BY NATIVE FUNGAL SPECIES INHABITING WASTEWATER OF A PHARMACEUTICAL FACTORY IN SANA’A, YEMEN

BIODEGRADATION OF PARACETAMOL BY NATIVE FUNGAL SPECIES INHABITING WASTEWATER OF A PHARMACEUTICAL FACTORY IN SANA’A, YEMEN

Authors: Wadhah Hassan Edrees, Qais Yusuf Abdullah, Khalid Mohamed Naji, Ali Gamal AL-Kaf
( 0 downloads)
Abstract

Lozenges are the flavoured solid, unit dosage medicated dosage forms usually in the sweetened base intended to be sucked and held in the mouth or pharynx containing one or more medicaments. Lozenges were developed in 20th century and is still under commercial production. These are medicated confections designed for local as well as systemic therapy. Carbamazepine (CBZ) is an anticonvulsant drug used in the treatment of epilepsy and neuropathic pain. It is used in schizophrenia along with other medications. In the present study an attempt has been made to prepare and evaluate the sugar based medicated Carbamazepine lozenzes to improve bioavailability and increase patient compliance specially for those patients who have difficulty in swallowing. The lozenges were prepared using sucrose as base; HPMC K4M, methyl cellulose were used as polymers. Eudragit was used as taste masking agent. Formulations were prepared by heating and congealing method on laboratory scale All the formulations prepared were subjected to various physicochemical parameters like hardness, friability, weight variation, drug content and in vitro dissolution studies. Stability studies of selected formulations of batch CL4 were also carried out at 40/75% relative humidity for 6 months for a period of six months. There wasn’t any substantial interaction between the drugs, flavor and color and other parameters and the prepared formulations were found to be stable.

Keywords: Lozenges, HPMC K4M, Carbamazepine (CBZ), swallowing, in vitro dissolution, stability studies
INVESTIGATION OF TOXIC METALS POLLUTION IN WATER, SEDIMENT AND FISH AT ADEN COAST, GULF OF ADEN , YEMEN

INVESTIGATION OF TOXIC METALS POLLUTION IN WATER, SEDIMENT AND FISH AT ADEN COAST, GULF OF ADEN , YEMEN

Authors: Mohammed Kassem Othman Al-qadasy, Abdulla Saleh Babaqi, Mukhtar Mohammed Al-Abyadh, Ali Gamal Ahmed Al-kaf
( 0 downloads)
Abstract

This study investigates concentrations of toxic metals, Lead and Cadmium in water, sediments and fish organs (muscle, liver and gill). Collected from Aden coast, gulf of Aden in Yemen. Water samples and sediment were taken from nine locations. Four fish species were collected (Lethrinus mahsena; Epinephelus areolatus; Thunnus tonggol and Sphyraena jello) were collected from the local commercial fishermen of Aden city during winter 2011, Summer 2012 and winter 2013. Lead concentration in sea water is 0.045-0.055 mg/l and Lead concentration in Sediment 33.512-35.726 µg/g dry wt., Cadmium concentration in sea water 0.006-0.010 mg/l, Cadmium concentration in sediment 1.944-2.004 µg/g dry wt., lead concentration is the highest in most fish gill samples 0.047-0.727 µg/g dry wt., where as in muscles is the lowest 0.020-0.116 µg/g dry wt., and in liver was 0.038- 0.267 µg/g dry wt. Cadmium concentration is the highest in most fish gill samples 0.033-0.609 µg/g dry wt., where as in muscles is the lowest 0.018- 0.073 µg/g dry wt., and in liver was 0.028-0.209 µg/g dry wt. By comparing the results obtained with other data obtained from the local and international studies, in addition to, comparing the results standard levels of these metals contaminated and adopted internationally and domestically and the pollution levels in Yemen is currently within the lower limits of pollution.

Keywords: Lead, Cadmium, fish, sediments, water, Aden, Yemen
COMPARISION OF ANTIDYSLIPIEMIC POTENTIAL OF 80 MILLIGRAMS OF FENOFIBRATED WITH 8 GRAMS OF NIGELLA SATIVA SEEDS DAILY

COMPARISION OF ANTIDYSLIPIEMIC POTENTIAL OF 80 MILLIGRAMS OF FENOFIBRATED WITH 8 GRAMS OF NIGELLA SATIVA SEEDS DAILY

Authors: Shah Murad Mastoi, Azmat Ali, Hina Aslam, Khalid Niaz
( 0 downloads)
Abstract

High lipid levels in blood circulation may interact with free radicals, formed in consequence of normal metabolic processes in human body. This interaction is one of the etiological factors for development of coronary artery disease (CAD). Just to keep normal plasma lipid levels may reduce risk for CAD. To compare hypolipidemic potential of herb nigella sativa with allopathy-related hypolipidemic agent Fenofibrate, we conducted this research. It was single blind placebo-controlled study conducted at Ghurki trust teaching hospital, Lahore from February 2017 to July 2017. 75 diagnosed secondary hyperlipidemic patients were selected with age range from 20 to 70 years. Patients suffering from hypothyroidism, diabetes mellitus, any gastrointestinal upset, renal impairment, and any hepatic or cardiac disease. All patients were divided in three groups (group-A, group-B, group-C), 25 in each group. The study period was eight weeks. Twenty five patients of group-A were advised to take two grams of Kalonji, twice daily. Twenty five patients of group-B were advised to take Fenofibrate 40 mg tablets, BD ie; one after breakfast and one after dinner. Twenty five patients were provided placebo capsules, (containing grinded sorghum), taking one capsule after breakfast and another before going to bed. All participants were advised to take these medicines for eight weeks. Serum LDL-cholesterol was calculated by Friedwald formula1 (LDL-Cholesterol = Total Cholesterol-(Triglycerides/5 +HDL-Cholesterol). Data were expressed as the mean ± SD and “t” test was applied to determine statistical significance as the difference. A probability value of <0.05 was considered as non-significancant and P<0.001 was considered as highly significant change in the results when pre and post-treatment values were compared. After 8 weeks when results were compiled and analyzed statistically, it was observed that Kalonji reduced total cholesterol (TC), triglycerides (TG) , and LDL-cholesterol highly significantly. HDL-cholesterol was increased in this group significantly with p-value <0.01. Fenofibrate decreased TC, TG, and LDL-cholesterol highly significantly with p-value <0.001, while increase in HDL-cholesterol was significant with p-value <0.01. It was concluded from this study that hypolipidemic potential of herbal medication NIGELLA SATIVA is comparably same as hypolipidemic potential of allopathy related drug Fenofibrate when given in large amount (ie; 4 grams daily) for specific time.

Keywords: lipid levels, hypolipidemic potential, nigella sativa, Fenofibrate

About Europub

EuroPub is a comprehensive, multipurpose database covering scholarly literature, with indexed records from active, authoritative journals, and indexes articles from journals all over the world. The result is an exhaustive database that assists research in every field. Easy access to a vast database at one place, reduces searching and data reviewing time considerably and helps authors in preparing new articles to a great extent. EuroPub aims at increasing the visibility of open access scholarly journals, thereby promoting their increased usage and impact.