SOLID DISPERSION- STRATEGY TO ENHANCE SOLUBILITY AND DISSOLUTION OF POORLY WATER SOLUBLE DRUGS

Journal Title: Universal Journal of Pharmaceutical Research - Year 2017, Vol 2, Issue 5

Abstract

Improving oral bioavailability of drugs those given as solid dosage forms remains a challenge for the formulation scientists due to solubility problems. Over the years a variety of solubilization techniques have been studied and widely used, as maximum drugs are poorly water soluble in pharmaceutical field. The enhancement of dissolution rate and oral bioavailability is one of the greatest challenges in the development of poorly water soluble drugs. Solid dispersions have attracted many researchers as an efficient means of improving the dissolution rate and hence the bioavailability of a range of poorly water-soluble drugs. The term solid dispersion refers to a group of solid products consisting of at least two different components, generally a hydrophilic inert carrier or matrix and a hydrophobic drug. Solid dispersion can form either a eutectic mixture or solid solution or glass solution or amorphous precipitation in a crystalline carrier or compound or complex formation. The focus of this review article is on the advantages, limitations, various methods of preparation and characterization of the solid dispersion.

Authors and Affiliations

Ankush Kumar, Kapil Kumar

Keywords

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SOLID DISPERSION- STRATEGY TO ENHANCE SOLUBILITY AND DISSOLUTION OF POORLY WATER SOLUBLE DRUGS

Improving oral bioavailability of drugs those given as solid dosage forms remains a challenge for the formulation scientists due to solubility problems. Over the years a variety of solubilization techniques have been stu...

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  • EP ID EP36418
  • DOI https://doi.org/10.22270/ujpr.v2i5.RW4
  • Views 306
  • Downloads 0

How To Cite

Ankush Kumar, Kapil Kumar (2017). SOLID DISPERSION- STRATEGY TO ENHANCE SOLUBILITY AND DISSOLUTION OF POORLY WATER SOLUBLE DRUGS. Universal Journal of Pharmaceutical Research, 2(5), -. https://europub.co.uk/articles/-A-36418