DEVELOPMENT AND EVALUATION OF TRANSDERMAL GEL OF LORNOXICAM

Journal Title: Universal Journal of Pharmaceutical Research - Year 2017, Vol 2, Issue 1

Abstract

The objective of the present study was to formulate solid dispersions (SD) of Ezetimibe to Transdermal drug delivery systems deliver the drug through the skin at controlled rate to the systemic circulation. It maintains the blood concentration of the drug within the therapeutic system window ensuring that drug levels neither fall below the minimum effective concentration nor exceed the minimum toxic dose. The objective of the present work was to formulate transdermal gel of Lornoxicam. It is a COX-1 and COX-2 inhibitor used in the treatment of inflammation, pain and edema, rheumatoid arthritis. Transdermal gel of Lornoxicam was formulated using triethanolamine as solvent, HPMC K100 and EC as polymers. Formulated gel was evaluated with respect to different physiochemical parameters such as pH, viscosity, spreadability. In–vitro release study was performed for 10 hrs. Selected formulation was subjected to stability testing at different temperatures.

Authors and Affiliations

Saifullahi Umar, Moh Kingsley Onyekachi

Keywords

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  • EP ID EP36377
  • DOI https://doi.org/10.22270/ujpr.v2i1.R4
  • Views 340
  • Downloads 0

How To Cite

Saifullahi Umar, Moh Kingsley Onyekachi (2017). DEVELOPMENT AND EVALUATION OF TRANSDERMAL GEL OF LORNOXICAM. Universal Journal of Pharmaceutical Research, 2(1), -. https://europub.co.uk/articles/-A-36377