DEVELOPMENT AND EVALUATION OF TRANSDERMAL GEL OF LORNOXICAM
Journal Title: Universal Journal of Pharmaceutical Research - Year 2017, Vol 2, Issue 1
Abstract
The objective of the present study was to formulate solid dispersions (SD) of Ezetimibe to Transdermal drug delivery systems deliver the drug through the skin at controlled rate to the systemic circulation. It maintains the blood concentration of the drug within the therapeutic system window ensuring that drug levels neither fall below the minimum effective concentration nor exceed the minimum toxic dose. The objective of the present work was to formulate transdermal gel of Lornoxicam. It is a COX-1 and COX-2 inhibitor used in the treatment of inflammation, pain and edema, rheumatoid arthritis. Transdermal gel of Lornoxicam was formulated using triethanolamine as solvent, HPMC K100 and EC as polymers. Formulated gel was evaluated with respect to different physiochemical parameters such as pH, viscosity, spreadability. In–vitro release study was performed for 10 hrs. Selected formulation was subjected to stability testing at different temperatures.
Authors and Affiliations
Saifullahi Umar, Moh Kingsley Onyekachi
Keywords
Related Articles
- EP ID EP36377
- DOI https://doi.org/10.22270/ujpr.v2i1.R4
- Views 305
- Downloads 0
GC-MS ANALYSIS OF FIXED OILS OF NIGELLA SATIVA SEEDS
Gas chromatography-Mass spectrometry (GC-MS) is an analytical method that combines the features of gas-liquid chromatography and mass spectrometry to identify different substances within a test sample. Applications of GC...
INTERLEUKIN-22 SERUM LEVELS IN PATIENTS WITH RHEUMATOID ARTHRITIS IN SANA'A CITY, YEMEN
Interleukin (IL) -22 is a novel mediator of a member of IL-10 family cytokines that is produced by many different types of lymphocytes including both those of innate and adaptive immune system. This cytokine has potent p...
MYOCARDIAL POTENCY OF AQUEOUS EXTRACT OF HARUNGANA MADAGASCARIENSIS STEM BARK AGAINST ISOPROTERENOL-INDUCED MYOCARDIAL DAMAGE IN RATS
The present study was undertaken to evaluate the effects of Harungana madagascariensis on electrocardiographical, biochemical and histopathological changes in isoproterenol (ISO)-induced myocardial infarction in rats. M...
EXTRACTION AND PHYSICOCHEMICAL CHARACTERIZATION OF NOVEL POTENT MUCOADHESIVE BIO-MATERIAL OBTAINED FROM THE FRESH FRUITS PULP OF ACHRAS ZAPOTILLA
The objective of present investigation was to isolate an effective novel mucoadhesive biomaterial from the pulp of Achras Zapotilla, belonging to Sapotaceae family. In the recent years the research in the biomaterial iso...
Editorial Message.
It gives me immense pleasure to express my deepest congratulations to all staff and members of Universal Journal of Pharmaceutical Research (UJPR) for their progressive and steady success in scientific publication pathwa...