Universal Journal of Pharmaceutical Research

Universal Journal of Pharmaceutical Research

Basic info

  • Publisher: UJPR
  • Country of publisher: india
  • Date added to EuroPub: 2019/Feb/24

Subject and more

  • LCC Subject Category: Medicine
  • Publisher's keywords: Pharmaceutics, Pharmacology, Pharmaceutical Chemistry, Pharmacognosy and Phytochemistry, Biopharmaceutics, Pharmaceutical Analysis, Pharmaceutical Microbiology, Pharmaceutical Biotechnology, Pharmacology and Toxicology, Clinical Pharmacy, Bioinformatics, Pharmaceutical Management, Health Care Management, Hospital Management, Biochemistry, Regulatory Affairs
  • Language of fulltext: english
  • Full-text formats available: PDF

Publication charges

  • Article Processing Charges (APCs): Yes 100 USD
  • Submission charges: No
  • Waiver policy for charges? Yes

Editorial information

Open access & licensing

  • Type of License: CC BY
  • License terms
  • Open Access Statement: Yes
  • Year open access content began: 2016
  • Does the author retain unrestricted copyright? False
  • Does the author retain publishing rights? False

Best practice polices

  • Permanent article identifier: DOI
  • Content digitally archived in: Nopolicy
  • Deposit policy registered in: None

This journal has '151' articles

PREVALENCE OF PSEUDOMONAS AERUGINOSA (P. AERUGINOSA) AND ANTIMICROBIAL SUSCEPTIBILITY PATTERNS AT A PRIVATE HOSPITAL IN SANA'A, YEMEN

PREVALENCE OF PSEUDOMONAS AERUGINOSA (P. AERUGINOSA) AND ANTIMICROBIAL SUSCEPTIBILITY PATTERNS AT A PRIVATE HOSPITAL IN SANA'A, YEMEN

Authors: Ali Alyahawi, Abdul Monem Alhomidi, Nawal Al-Henhena
( 0 downloads)
Abstract

Pseudomonas aeruginosa is clinically significant and opportunistic pathogenthat causes infections in hospitalized patients. Antibiotic resistance is a major concern in clinical practice. The ongoing emergence of resistant strains that cause nosocomial infections contributes substantially to the morbidity and mortality of hospitalized patients. Objective of present study was to estimate the prevalence of Pseudomonas aeruginosa and the antimicrobial resistance patterns of P. aeruginosa isolates from hospitalized patients. The study was performed at microbiology department of a local hospital in Sana’a, Yemen. All the patients' samples of hospital departments from January, 2017 to December, 2017 were included. A Total of 2079 samples were collected during the study period. Among them, 193 strains of Pseudomonas spp. were isolated. One hundred ninety three isolates of P. aeruginosa were isolated from different clinical specimens and fully characterized by standard bacteriological procedures. Antimicrobial susceptibility pattern of each isolates was carried out by the Kirby-Bauer disk diffusion method as per CLSI guidelines. Majority of P. aeruginosa were isolated from Sputum, followed by urine specimens. The isolate pathogen showed the highest sensitive to Meropenem (85.5%), followed by Amikacin (80.5%), Imipenem (80.0%), and Piperacillin/tazobactam (77.2). The highest frequency of resistance (96.2%) was observed with amoxicillin /clavulinic Acid followed by cefuroxime 94.6%, ampicillin/ sulbactam 94.5%, Co-Trimoxzole 80.5%, and norfloxacin 54%. The result confirmed the occurrence of drug resistance strains of P. aeruginosa. Meropenem, imipenem, and amikacin, were found to be the most effective antimicrobial drugs. It therefore calls for a very judicious, appropriate treatment regimens selection by the physicians to limit the further spread of antimicrobial resistance P. aeruginosa.

Keywords: antimicrobial susceptibility, Imipenem, multi drug-resistant, Pseudomonas aeruginosa
FORMULATION AND EVALUATION OF IBUPROFEN GASTRO-RETENTIVE FLOATING TABLETS

FORMULATION AND EVALUATION OF IBUPROFEN GASTRO-RETENTIVE FLOATING TABLETS

Authors: Saddam C Shaikh, Dnyaneshwar Sanap, Dipak V Bhusari, Shirish Jain, Pooja P Kochar, Vikram N Sanchati
( 0 downloads)
Abstract

The objective of the present study was to formulate the gastro-retentive floating tablets containing Ibuprofen, which would remain in stomach and/or upper part of GIT for prolonged period of time. Floating systems have low bulk density so that they can float on the gastric juice in the stomach. Ibuprofen is an anti inflammatory drug. On trial and error basis formulation design was done. Four different batches of floating tablets of Ibuprofen were prepared using HPMC, Xanthan gum, and gas generating agent sodium bicarbonate and citric acid. The tablets were characterized for the pre and post compression parameters such as friability, hardness, thickness, drug content, weight variation, in-vitro buoyancy studies and 13 hrs in-vitro drug release studies and the results were within the limits. From the results obtained, it was concluded that the optimized formulation F4 desired drug release properties and floating behavior.

Keywords: Citric acid, gastro-retentive floating tablets, HPMC K4M, Ibuprofen, sodium bicarbonate, xanthan gum
THE IMPACT OF STRATEGIC FACTORS OF WASTE MANAGEMENT ON ENVIRONMENTAL PROTECTION IN KAZEROON CITY IN 2017

THE IMPACT OF STRATEGIC FACTORS OF WASTE MANAGEMENT ON ENVIRONMENTAL PROTECTION IN KAZEROON CITY IN 2017

Authors: Mohammadrafi Mehbodi, Abbas Yazdanpanah, Jamalledin Alvaani
( 0 downloads)
Abstract

Today, environment protection is one of main pillars of observing human right, so that protection and maintenance of environment is one of main duties of present and future. After investigating and identifying environmental factors including internal and external environment of waste management and preparing a list of the most important strengths and weaknesses, opportunities and threats ( 40 factors) and selecting the most important factors participatory (24 factors) using EFE and IFE matrix, they were analyzed and evaluated and the score was determined and in the following, using the matrix and regarding internal and external factors, the most suitable strategies were introduced for optimal management of waste system of the studied region and in the next stage, using the matrix score of evaluating internal and external factors and strategies of matrix formation matrix, the present status of the organization (IE), the preservative approach was selected as goal approach and attraction of any preservative strategies was specified in the qualitative strategic planning matrix (QSPM). It should be said that the order of approaches priority is based on their so-called genera weight rate and movement towards sustainable development that based on the attraction score, the priorities became in this order that the first priority is related to strategy and then respectively optimizing various stages of wastes management, increasing awareness and changing the individuals attitude towards correct method of waste management like reduction of waste production, separation of recyclable materials at home and method of collecting through holding training classes, preparing and distributing advertising posters in the cities, implementing plan of separation from origin and its success requires public participation and cooperation.

Keywords: Environment, strategy, waste management
QUALITY CONTROL ASSESSMENT OF DIFFERENT BRANDS OF CIPROFLOXACIN 500 MG TABLETS IN YEMEN

QUALITY CONTROL ASSESSMENT OF DIFFERENT BRANDS OF CIPROFLOXACIN 500 MG TABLETS IN YEMEN

Authors: Ali Alyahawi, Abdulmajed Alsaifi
( 0 downloads)
Abstract

Ciprofloxacin is a fluorinated 4-quinolone or fluoroquinolone antibacterial with a wider spectrum of activity than nalidixic acid and more favorable pharmacokinetics allowing its use in systemic infections. It has been used in the treatment of a wide range of infections. Many different brands and dosage forms of Ciprofloxacin hydrochloride are available in the Sana'a market that places health practitioners in a dilemma of drug substitution in case of non-availability of a particular brand. The aim of the present study was to evaluate the quality control of five brands of Ciprofloxacin hydrochloride tablets marketed and commonly prescribed in Sana'a city. The results and findings of the present study will be interpreted and discussed. Five brands of Ciprofloxacin hydrochloride tablets (500 mg) were purchased from the retail pharmacy outlets and their pharmaceutical quality were assessed by using in-vitro tests as per the British Pharmacopoeia (BP) and unofficial standards as recommended by the manufacturers. The assessment of tablets included the evaluation of uniformity of weight, friability, hardens, disintegration time, dissolution test and assay content by UV spectrophotometric method. All brands passed USP and BP standards in- vitro quality control tests prescribed for the tablets except hardens test but the all products were satisfactory for hardness. The results indicated that the overall quality of all tested Ciprofloxacin hydrochloride tablets brands was satisfactory as they met the requirements of the official and unofficial quality control tests.

Keywords: Ciprofloxacin HCl, dissolution, disintegration, friability, hardness, Quality control
FABRICATION AND EVALUATION OF HERBAL OINTMENT FORMULATIONS OF MORINGA OLIFERA FOR TOPICAL DELIVERY

FABRICATION AND EVALUATION OF HERBAL OINTMENT FORMULATIONS OF MORINGA OLIFERA FOR TOPICAL DELIVERY

Authors: Saddam C Shaikh, Dnyaneshwar Sanap, Dipak V Bhusari, Shirish Jain, Pooja P Kochar, Fahim S Memon
( 0 downloads)
Abstract

Traditional medicine is an important source of potentially useful new compounds for the development of chemotherapeutic agents. Moringa oleifera Lam. is a multipurpose and exceptionally nutritious vegetable tree with a variety of potential uses. It is distributed in many countries of the tropics and subtropics. Ointments are semisolid systems which behave as viscoelastic materials when shear stress is applied. They contain medicaments and are intended to be applied externally to the body or to the mucous membrane. In present study the Morenga oleifera leaves extract was used to formulate four different ointment formulations with different bases like cetostearyl alcohol, hard paraffin, and liquid paraffin. Formulations were evaluated for different parameters such as general appearance, spreadability, pH, extrudability, centrifugation, irritancy, loss on drying, stability study etc;

Keywords: herbal ointment, leaves extract, Moringa oleifera Lam, semisolid systems
QUALITY ASSESSMENT OF DIFFERENT BRANDS OF PARACETAMOL TABLETS IN YEMENI MARKET

QUALITY ASSESSMENT OF DIFFERENT BRANDS OF PARACETAMOL TABLETS IN YEMENI MARKET

Authors: Abdulmajed Alsaifi, Ali Alyahawi
( 0 downloads)
Abstract

Paracetamol or acetaminophen is active metabolites of phenacitin. It is a widely used over-the-counter analgesic and antipyretic. Chemically, it is 4-hydroxy acetanilide (acetaminophen). Paracetamol is approved for reducing fever in people of all ages. It is commonly used for the relief of headaches, other minor aches and pains, and is a major ingredient in numerous cold and flu remedies. Many different brands and dosage forms of paracetamol are available in Yemeni market that places health practitioners in a dilemma of drug substitution in case of non-availability of a particular brand. The aim of the present study was to evaluate the quality control of four brands of paracetamol tablets (500 mg) marketed and commonly prescribed in Yemeni market. The results and findings of the present study will be interpreted and discussed. Four brands of paracetamol tablets (500 mg) were purchased from the retail pharmacy outlets and their pharmaceutical quality were assessed by using in-vitro tests according to USP and BP standards and unofficial standards as recommended by the manufacturers. The assessment of tablets included the evaluation of uniformity of weight, hardens, friability, disintegration time, dissolution test as well as assay content by UV spectrophotometric method. All brands passed USP and BP standards in- vitro quality control tests prescribed for the tablets except hardens test but all products were satisfactory for hardness. The results indicated that the overall quality of all tested paracetamol tablets brands was satisfactory as they met the requirements of the official and unofficial quality control tests.

Keywords: dissolution, disintegration, friability, hardness, paracetamol, Quality control
IN VITRO ANTI-LEISHMANIAL ACTIVITY AGAINST CUTANEOUS LEISHMANIA PARASITES AND PRELIMINARY PHYTOCHEMICAL ANALYSIS OF FOUR YEMENI MEDICINAL PLANTS

IN VITRO ANTI-LEISHMANIAL ACTIVITY AGAINST CUTANEOUS LEISHMANIA PARASITES AND PRELIMINARY PHYTOCHEMICAL ANALYSIS OF FOUR YEMENI MEDICINAL PLANTS

Authors: Manal Mutahar Ali Al- Hajj, Hassan A Al-Shamahy, Bushra Y Alkhatib, Bushra A Moharram
( 0 downloads)
Abstract

Cutaneous leishmaniasis is one form of leishmaniasis that chiefly infected the poor sections of the society. The prototypical therapeutic interventions in vogue are handicapped due to toxicity and an alarming increase in drug resistance. Furthermore, the absence of vaccines has raised the quest for alternative therapies. So, the aim of our study was to assess the anti-leishmanial activity of Euphorbia cactus Ehrenb, Euphorbia ammak Forssk, Euphorbia inarticulate Schweinf, and Pergularia tomentosa L. The extracts of plants were prepared by maceration method and by Soxhlet extractor. The extracts were dried and re-dissolved in 2% dimethyl sulfoxide (DMSO) 1% solvent. Leishmania spp. cells were then tested with serial concentrations (15.6 μgml-1 to 500 μg ml-1 ) of the extracts, using the 3-(4,5-dimethylthazolk-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay. All experiments were performed in triplicate and analyzed by ANOVA test. The optical density values as measured by Enzyme-Linked Immunosorbent Assay (ELISA) were used to calculate the IC50 values. The results indicated that the methanolic latex extract of Euphorbia cactus Ehrenb, Euphorbia ammak Forssk had potent anti-leishmanial activity against the promastigotes of Leishmania spp. based on a dose-dependent response analysis. The IC50 values for Euphorbia cactus Ehrenb and Euphorbia ammak Forssk after 24h incubation against Leishmania spp. promastigotes were less than <15.6 μgml-1. Furthermore, the phytochemical analysis of methanolic extracts showed the presence of alkaloids, phytosterols, phenols, saponins, and flavonoids in which these components have been proven previously to be the active compounds against Leishmania parasite. In conclusion, the present study reveals that latex extract of Euphorbia cactus Ehrenb and Euphorbia ammak Forssk contain active compounds that have anti-leishmanial activity, which could serve as an alternative agent in the treatment of Cutaneous leishmaniasis, but further studies would, therefore, be needed to assess the activity of these materials of this plants in vivo clinical response and study their toxicity on cell lines.

Keywords: Anti-leishmanial activity, Euphorbia cactus Ehrenb, Euphorbia ammak Forssk, Euphorbia inarticulate Schweinf, Pergularia tomentosa L, Yemeni medicinal plants
AWARENESS AMONGST YOUTH ABOUT USE AND ABUSE OF STEROIDS IN KARACHI, PAKISTAN

AWARENESS AMONGST YOUTH ABOUT USE AND ABUSE OF STEROIDS IN KARACHI, PAKISTAN

Authors: Auwais Ahmed Khan, Sana Ghayas, Amna Mehtab, Umm-e- Aaiman, Mehak Idrees, Fakhsheena Anjum
( 0 downloads)
Abstract

Aim of present study was to analyze awareness regarding the use of steroids in the youth studying health sciences. A descriptive, observational study was conducted from September to December 2017. Youth studying health sciences aged 21–25 years in Karachi were recruited for the study, among which (n=179) 50.99% were pharmacy students and (n=172) 49% were studying allied health sciences. Descriptive statistics (SPSS version 16.0) was used to analyze the results. Out of 400 questionnaires, the response rate was 87.75%. Majority students were knowledgeable about steroids and (72.64%) agreed that steroids should be sold as prescription only medicine in Pakistan (p= 0.00).Most of them n=147 (41.88%) had no idea about various modes of steroid abuse (p=0.00).Many participants (n= 109;31.05%) thought that steroids were found in toothpaste and dentifrices, cosmetics and ophthalmic preparations; n= 135 (38.46%) had no idea whether or not the steroids had interactions with opiates and cocaine, alcohol and benzodiazepines. The perception was seen in n= 118 (33.61%) persons that nutritional alternative/supplements could be used to reduce steroid abuse; n= 79 (22.50%) used steroids for grooming upon prescription by medical practitioner. Allergic reactions were thought as the mild side effects of steroid use by n= 100 (28.24%) while n= 166 (47.29%) considered kidney and liver diseases as severe side effects of steroid use (p=0.00). It was noted that comprehensive information about the steroids was required by youth since they were studying health sciences. Some modifications in the curriculum have to be made for providing more information about substances like steroids to the health sciences students as steroids have a great impact not only physically but also psychologically.

Keywords: abuse, anabolic androgenic steroids, Steroids misuse
FAST DISSOLVING DRUG DELIVERY SYSTEMS: FORMULATION, PREPARATION TECHNIQUES AND EVALUATION

FAST DISSOLVING DRUG DELIVERY SYSTEMS: FORMULATION, PREPARATION TECHNIQUES AND EVALUATION

Authors: Satbir Singh, Tarun Virmani, Reshu Virmani, Geeta Mahlawat, Pankaj Kumar
( 0 downloads)
Abstract

The Fast Dissolving Drug Delivery Systems sets a new benchmark was an expansion that came into existence in the early 1980’s and combat over the use of the different dosage form like tablets, suspension, syrups, capsules which are the other oral drug delivery systems. Fast Dissolving Drug Delivery System (FDTS) has a major advantage over the conventional dosage forms since the drug gets rapidly disintegrated and dissolves in the saliva without the use of water .In spite of the downside lack of immediate onset of action; these oral dosage forms have valuable purposes such as self medication, increased patient compliance, ease of manufacturing and lack of pain. Hence Fast Disintegrating Tablets (FDTS) technology has been gaining importance now-a-days with wide variety of drugs serving many purposes. Fast Disintegrating Tablets (FDTS) has ever increased their demand in the last decade since they disintegrate in saliva in less than a minute that improved compliance in pediatrics and geriatric patients, who have difficulty in swallowing tablets or liquids. As fast dissolving tablet provide instantaneous disintegration after putting it on tongue, thereby rapid drug absorption and instantaneous bioavailability, whereas Fast dissolving oral films are used as practical alternative to FDTS. These films have a potential to deliver the drug systemically through intragastric, sublingual or buccal route of administration and also has been used for local action. In present review article different aspects of fast dissolving tablets and films like method of preparations, latest technologies, evaluation parameters are discussed. This study will be useful for the researchers for their lab work.

Keywords: bioavailability, dysphagia, fast disintegrating tablet, Fast Dissolving drug delivery systems, geriatric, pediatric
Editorial Message...

Editorial Message...

Authors: Prof. Dr. Ali Gamal Al-kaf
( 0 downloads)
Abstract

It is great honor and high pleasure to be appointed as member- Editorial Board, then as executive editor, Universal Journal of Pharmaceutical Research (UJPR). My heartiest salutations and warm congratulation to all editorial board members for their high success of today through their hard work and persistence. Actually, UJPR is now recognized as an international and indexed journal in more than 30 locations and i think that our journal will achieve an impact factor and will be member of Scopus and ISI journals in the nearest future. Universal Journal of Pharmaceutical Research (UJPR) with its high qualified editorial board members, high quality manuscripts and excellence of those reviewing the manuscripts will enable to go ahead and get a high reputation over the world. I will take this opportunity to appeal to all authors to prepare their manuscripts strictly according to journal instructions so as to avoid any undue delay in its editorial processing and disappointment of rejection. At last i hope for our journal high success and to generate an impact factor for which we invite submission of more original articles and citation of relevant literature published in this journal in your future publications.

Keywords: Yemen
ANTIDIABETIC AND ANTIHYPERLIPIDEMIC ACTIVITY OF DRACAENA CINNABARI BALF. RESIN ETHANOLIC EXTRACT OF SOQATRA ISLAND IN EXPERIMENTAL ANIMALS

ANTIDIABETIC AND ANTIHYPERLIPIDEMIC ACTIVITY OF DRACAENA CINNABARI BALF. RESIN ETHANOLIC EXTRACT OF SOQATRA ISLAND IN EXPERIMENTAL ANIMALS

Authors: Nahed Al-Baoqai, Hassan Al-Mahbashi, Adnan Al-Adhal
( 0 downloads)
Abstract

Dracaena Cinnabari balf is a species plant in Agavaceae family. It is a tree endemic to the Island of Socotra,Yemen. It was used as a dye and medicine in Socotra and the Mediterranean basin. Some researches demonstrated both hypoglycemic and hypolipidemic of its resin of Dracaena Cochinchinensis, a traditional Chinese tree. Accordingly, this study aimed to evaluate the antidiabetic potential of the ethanolic extract of dracanea cinnabari balfresin (DCBR), endemic in Socotra Island, in Alloxan induced diabetes, and evaluation of possible antihyperlipidemic activity of the same extract in high-cholesterol diet-induced hyperlipidemia in male albino rats. Experimental diabetes was induced in rats with intraperitoneal injection a single dose of Alloxan (150 mg/kg). Hyperlipidemia was induced in rats by administration of 1% cholesterol in diet and 0.5 % Hydrogen Peroxide in drinking water for 14 days. Fasting blood glucose levels were measured at 1st day, 7th day and 14th day. Pancreas histopathology was done at the end. Estimation of serum lipid profile and liver histopathology was done at the end of 14 day. The results were expressed as mean±SD and differences among the groups of animals were compared using one-way ANOVA. Administration of ethanolic extract of resin of two doses (100 and 300mg\kg) in alloxan induce diabetic rats resulted in a significant decrease in FBG levels with a recovery in destruction of pancreas cell compared with untreated group. Also the same doses of extract showed significant decrease in triglycerides, total cholesterol, low density lipoprotein, very low density lipoprotein and alkaline phospatase in comparing with untreated group. From the results of present study we can conclude the ethanolic extract of Dracaena Cinnabari Balf. have a hypoglycemic and hypolipidemic activity in experimental animals, these activity are time and dose dependent.

Keywords: alloxan, blood glucose, diabetes, Dracanea Cinnabari, flavonoids, glibenclamide, resin
A CROSS-SECTIONAL STUDY ON BENZODIAZIPINE (BZD) ABUSERS OF DHAKA CITY: A SOCIO-PSYCHOLOGICAL CONDITION OF BANGLADESH

A CROSS-SECTIONAL STUDY ON BENZODIAZIPINE (BZD) ABUSERS OF DHAKA CITY: A SOCIO-PSYCHOLOGICAL CONDITION OF BANGLADESH

Authors: Forhad Monjur, Farhana Rizwan
( 0 downloads)
Abstract

Benzodiazepines (BZD) are highly potential drug for abuse among the most frequently prescribed medicine. Different studies say that young-adults are the vulnerable population of BZD misuse in Bangladesh. The aim of the study was designed to evaluate the BZD drug abuser with relation to its impact on socio-psychological condition of Dhaka city. A cross sectional study consisted of 468 current BZD users. The participants were chosen randomly. Structured questionnaires included participant’s personal information; drug use characteristics; physiological and psychological effects of drugs. Verbal consent was taken from each respondent. In this study, 96.15% were male where 40.39 % of respondents were from the age group 23-27 years. 57.70 % participants were single. Here, 34.62 % were student, 40.38 % had monthly family income above 50,000 BDT. BZD was used to relive from stress/pressure by 23.07%, from insomnia by 13.46% of respondents. The drug of choice was diazepam for 44.24% respondents. Most of the users (44.23%) were influenced by friends. 32.69% participant concomitantly used BZD with YABA. The common problem was amnesia, confusion and difficulty in cognition. The withdrawal effects were rebound insomnia, anxiety, headache; restlessness and so on. Drug abuse is a serious public health problem worldwide. Therefore, these findings may help Government or policymakers to take initiative for drug addict. Moreover, there is need of further research on these topics in different area of Bangladesh to get the complete scenario of drug abuse, especially BZD abuse.

Keywords: Benzodiazepines (BZD), Drug abuser, Drug misuse, Withdrawal effects
CURRENT TREND OF RESISTANT FOR THE COMMONLY PRESCRIBED NEW FLUOROQUINOLONES AMONG HOSPITALISED PATIENTS IN SANA'A, YEMEN

CURRENT TREND OF RESISTANT FOR THE COMMONLY PRESCRIBED NEW FLUOROQUINOLONES AMONG HOSPITALISED PATIENTS IN SANA'A, YEMEN

Authors: Ali Alyahawi, Ali Alkaf, Taha Alnosary
( 0 downloads)
Abstract

The new fluoroquinolones have demonstrated enhanced activity against the most common bacteria involved in lower respiratory tract infection (LRTI). Moxifloxacin is the most commonly prescribed respiratory flouroquinolone drug in Yemen. Pneumonia is a major and an on-going public health problem globally. With the widely use of fluoroquinolones in the clinical practice, the potential for developing resistance has become a concern. The aim of present study was to determine the trend of moxifloxacin resistant and the distribution of resistant for different sample types among hospitalised patients in Sana'a, Yemen. The study was performed at a private hospital in Sana’a, Yemen. The records were taken from the microbiology department for hospitalised patients. Moxifloxacin susceptibility samples were collected from January, 2017 to December, 2017. The moxifloxacin susceptibility was studied against several isolates. Full ethical clearance was obtained from the qualified authorities who approved the study design. All data were analyzed using SPSS Statistics version 21. Out of 927 sample isolates, 580 (62.6%) were moxifloxacin resistant isolates and only 30.1% were sensitive. The Escherichia coli was observed in 24.4% of total sample isolates, followed by Pseudomonas aeruginosa (12.1%). From the study findings, 44.8% of total sample was isolated from sputum cultures.There was a statistically significant difference between bacteria type and culture results (P-value < 0.001). Moreover, 96.2% of Acinetobacter species and all Acinetobacter baumannii isolates were moxifloxacin resistant. The study findings reported that 70.4% of Escherichia coli isolates were resistant for moxifloaxin, followed by methicillin resistant staphylococcus aureus (64.7%), Klebsiella pneumonia (60.6%), and Pseudomonas aeruginosa (46.4%). However, 86.1% of staphylococcus aureus isolates were moxifloxacin resistant. Results in this study showed that there was high significantly relationship between culture results and sample type (P-value< 0.001). Also 44.8% of sample isolates were from sputum cultures. Moreover, 74.2% of sputum cultures isolates were moxifloxacin resistant. There was a statistically significant difference between culture results with age groups (P-value = 0.02). Also 64.1% of males had moxifloxacin resistant and 36.9% of isolate resistant were aged > 60 years. This study reveals that varieties of pathogens are responsible for LRTI and moxifloxacin resistance has become a great public health issue. The possibility of reducing resistance by controlling the use of antibiotics is a reasonable approach. Inappropriate and irrational drug usage should be avoided. This study may help the government’s regulatory authority to develop a policy about rational prescription of antibiotics to minimize resistance of new antibiotics and also to ensure the maximum safety to the health of patients.

Keywords: Moxifloxacin, prevalence, resistance
WOUND HEALING ACTIVITY OF JATROPHA TANJORENSIS LEAVES

WOUND HEALING ACTIVITY OF JATROPHA TANJORENSIS LEAVES

Authors: Madepalli Byrappa gowdu Viswanathan, Jesu Doss Jeya Ananthi, NataRajan Livingston Raja, Narayanan Venkateshan
( 0 downloads)
Abstract

The term “wound” is defined as a disruption of normal anatomical structure. Therefore, “healing” is the complex and dynamic process that results in the restoration of anatomical continuity and function. Albino Wistar rats (150-180 g) of both sexes were selected. The experiment of Wound Healing Activity by Excision Wound Model and Incision Wound Model by the simple ointment B.P., reference standard drug (0.2% w/w nitrofurazone ointment), stigmasterol ointment (0.2% w/w), hexane, chloroform and methanol extract ointments of 3%, 4% and 5% w/w of leaves in Jatropha tanjorensis in simple ointment base (where 3g, 4g and 5 g of the extracts was incorporated in 100 g of simple ointment separately). The time for wound closure to methanol extract ointment (5% w/w) and stigmasterol (0.2% w/w) was similar to that of standard drug, nitrofurazone ointment (0.2% w/w) 16 ± 2 days in Excision Wound Model. The significant tensile strength at 3%: 4%: 5% w/w methanol extract ointments (p<0.001), followed by chloroform extract and hexane extract. Stigmasterol ointment at 0.2% w/w produced tensile strength comparable with Standard drug, nitrofurazone ointment (0.2% w/w) (p<0.001) in Incision Wound Model. Kirithikar and basu stated that the juice of the Jatropha plant and the pounded leaves are applied to wounds and refractory ulcers. The juice is very successfully used to treat scabies, eczema and ringworm. The present study proved that the leaves have wound healing activity.

Keywords: excision, incision wound, Jatropha tanjorensis, leaves, wound healing
PREVALENCE OF CYTOMEGALOVIRUS IGG ANTIBODIES, POTENTIAL RISK FACTORS AND AWARENESS OF CONGENITAL CYTOMEGALOVIRUS AMONG FEMALE DOCTORS

PREVALENCE OF CYTOMEGALOVIRUS IGG ANTIBODIES, POTENTIAL RISK FACTORS AND AWARENESS OF CONGENITAL CYTOMEGALOVIRUS AMONG FEMALE DOCTORS

Authors: Mohammed Ali Abdullah Almoaish, Hassan A. Al-Shamahy, Manal Mutahar Ali Al- Hajj, Samera Muthanna Nasser Dainamah, Anwar G Al-Madhaji
( 0 downloads)
Abstract

Female staff in children-Mother care hospitals may run an increased risk of cytomegalovirus (CMV) contact infection leading to a congenital CMV feto-pathy during pregnancy. Also, because of limited treatment options for congenital cytomegalovirus infection, preventive strategies are important so knowledge and awareness among doctors are essential for the success of preventive strategies. Thus this study was carried out to determine the positive rate of IgG among female doctors at age bearing who care for children and mothers in Sana'a hospitals. Also, to investigate the knowledge of congenital CMV among doctors involved in the study. This cross sectional study was carried out for one year (June 2017- June 2018); 178 Yemeni female doctors were included in this study. 23 (12.9%) of the total female doctors were pediatrics, 32(18%) gynecology and obstetrics, 9 (5.1%) Oto-rhinolaryngology and 114 (64%) were general practices. Blood samples were collected from all participants and tested for IgG antibodies of HCMV by ELISA. The individual's data were collected in a pre-designed questionnaire including; demographic data, risk factors. Also, a questionnaire on CMV infection was answered by doctors on the knowledge concerning epidemiology, transmission, symptoms and signs of CMV infection in adults and children; and treatment options. 13.4% of female doctors were negative (HCMV IgG <9 SU), while the rest (86.6%) were positive (HCMV IgG ≥ 11 SU). There was escalate trend of positive HCMV IgG antibodies rate with increasing age, significance association between sero-positive HCMV IgG antibodies and parity (OR=3.1, p=0.01), 1-3 pregnancy rate (OR=2.2, p=0.05), and history of surgery (OR=3.8, p=0.01). Most of the doctors were aware that most healthy adults and pregnant women do not experience any symptoms of a CMV infection (66.8%); and only one-fifth of the respondents were aware that kissing, and changing diapers, are risk factors for the transmission of CMV. Also, only half of the total respondents were aware that microcephaly (59%), and hearing loss (56.7%) could be symptoms of congenital CMV. This study revealed that the HCMV is highly endemic in our population where the prevalence of IgG among the medical female doctors was 86.5%, thus HCMV should be considered as a possible cause of morbidity and mortality in fetus and might in mothers in Yemen. Increasing knowledge and awareness is expected to enhance the prevention of transmission, to improve recognition, and to stimulate diagnostic investigations and follow-up programs.

Keywords: awareness, CMV, knowledge, risk factors, staff in children-Mother care hospitals

About Europub

EuroPub is a comprehensive, multipurpose database covering scholarly literature, with indexed records from active, authoritative journals, and indexes articles from journals all over the world. The result is an exhaustive database that assists research in every field. Easy access to a vast database at one place, reduces searching and data reviewing time considerably and helps authors in preparing new articles to a great extent. EuroPub aims at increasing the visibility of open access scholarly journals, thereby promoting their increased usage and impact.