1,2-Diazole prevents cisplatin-induced nephrotoxicity in experimental rats.
Journal Title: Pharmacological Reports - Year 2013, Vol 65, Issue 4
Abstract
Cisplatin (a platinum-compound) is a anti-neoplastic drug used in the treatment of various cancers but eventually results in severe adverse effects namely nephrotoxicity or renal disorder through generation of reactive oxygen species (ROS). This biochemical measurements and histopathology analysis investigated a possible protective effect of 1,2-diazole with regards to cisplatin-induced nephrotoxicity in experimental animals.
Authors and Affiliations
Venugopal Prabhu, Narayanan Kannan, Chandrasekharan Guruvayoorappan
Keywords
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