Central effects of nafadotride, a dopamine D(3) receptor antagonist, in rats. Comparison with haloperidol and clozapine.
Journal Title: Pharmacological Reports - Year 2005, Vol 57, Issue 2
Abstract
The aim of this study was to examine behavioral and biochemical effects of nafadotride, the new dopamine D(3) receptor antagonist, and to compare it with haloperidol (dopamine D(2) receptor antagonist) and clozapine (predominate dopamine D(4) receptor antagonist). Each drug was injected to adult male Wistar rats intraperitoneally, each at a single dose and for 14 consecutive days. Thirty minutes after single or last injection of the examined drugs, the following behavioral parameters were recorded: yawning, oral activity, locomotion, exploratory activity, catalepsy and coordination ability. By HPLC/ED methods, we determined the effects of the examined antagonists on the levels of biogenic amines in striatum and hippocampus: dopamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), 3-methoxytyramine (3-MT), 5-hydroxytryptamine (5-HT), 5-hydroxyindoleacetic acid (5-HIAA) and noradrenaline (NA). Additionally, DA and 5-HT synthesis rate was determined in striatum and 5-HT in hippocampus. The results of the study indicate that nafadotride, the dopamine D(3) receptor antagonist, has a behavioral and biochemical profile of action different from that of haloperidol but partially similar to that of clozapine.
Authors and Affiliations
Grzegorz Kuballa, Przemysław Nowak, Łukasz Labus, Aleksandra Bortel, Joanna Dąbrowska, Marek Swoboda, Adam Kwieciński, Richard Kostrzewa, Ryszard Brus
Keywords
Related Articles
- EP ID EP133815
- DOI -
- Views 121
- Downloads 0
Molecular assessment of the potential combination therapy of cytokines with biphalin and AZT for Friend leukemia virus infection in vitro.
Biphalin, a dimeric enkephalin analog, is under investigation as a potential, long-lasting medication of pain associated with chronic diseases, like cancer or AIDS. The role of cytokines, and splenocytes in anti-Friend l...
Infection and atherosclerosis. An alternative view on an outdated hypothesis.
Already at the beginning of the 20th century, a potential role for microbes in vascular diseases was suggested. However, not until the late '70 of that century, much attention has been paid to this infection hypothesis....
Ephedrine-caffeine mixture in wet-cold stress.
Our investigations were aimed at studying the possibility of enhancement of homeostatic processes protecting against excessive body cooling by using thermogenic drugs. We studied the influence of ephedrine (1 mg/kg) and...
Antiarrhythmic and hypotensive activities of 1-[2-hydroxy-3-(4-phenyl-1-piperazinyl)propyl]-pyrrolidin-2-one (MG-1(R,S)) and its enantiomers.
The compound MG-1(R,S), (1-[2-hydroxy-3(4-phenyl-1-piperazinyl)propyl]-pyrrolidin-2-one, and its enantiomers were tested for electrocardiographic, antiarrhythmic and hypotensive activities. The racemic mixture (MG-1(R,S)...
LPS-induced oxidative stress and inflammatory reaction in the rat striatum.
Inflammation-induced microglia activation and increased oxidative stress have been observed in neurodegenerative disorders, such as Parkinson's disease. The aim of our study was to determine the appropriate dose and rout...