677C > T and 1298A > C MTHFR polymorphisms affect arechin treatment outcome in rheumatoid arthritis.
Journal Title: Pharmacological Reports - Year 2007, Vol 59, Issue 6
Abstract
Despite the availability of several new agents for the treatment of rheumatoid arthritis (RA), arechin (hydroxychloroquine) remains the mainstay because of both cost-effectiveness and experience with its use. However, there is considerable variation in response to this drug, with toxicity limiting treatment in some patients. Methylenetetrahydrofolate reductase (MTHFR) is involved in the folate metabolism and has been shown to be polymorphic what affects the enzyme activity. To examine the association between 677C > T and 1298A > C MTHFR polymorphisms and arechin efficacy in the treatment of RA, a total of 50 RA patients, treated with arechin were analyzed. In univariate regression analysis model, MTHF R 677T allele was associated with significantly higher frequency of remission, whereas 1298C allele carriers showed a tendency to higher remission rate. In univariate regression analysis model, the presence of MTHFR 677T allele was associated with 2.3-fold higher frequency of remission. Multivariate regression analysis taking into the account the combined effect of MTHFR 677T and 1298C alleles revealed that both alleles were independent factors associated with increased frequency of remission. The results of our study suggest that 677T and 1298C alleles are independent factors associated with increased frequency of remission and the evaluation of C677C > T and A1298A> C MTHFR polymorphisms may be a useful tool to predict arechin treatment outcome in RA patients.
Authors and Affiliations
Andrzej Pawlik, Mateusz Kurzawski, Wanda Górnik, Ewa Dąbrowska-Żamojcin, Marek Droździk
Keywords
Related Articles
- EP ID EP144506
- DOI -
- Views 117
- Downloads 0
Neonatal serotonin (5-HT) depletion does not disrupt prepulse inhibition of the startle response in rats.
The neurodevelopmental hypothesis of many brain disorders is based on the notion that environmental factors have significant effects on brain maturation. Because serotonin (5-HT) dysfunction in development may be involve...
Association of the MDR1 (ABCB1) gene 3435C>T polymorphism with male infertility.
Infertility is a common problem affecting one in six couples, and in 30% of infertile couples, the male factor is a major cause due to defective sperm quality. P-glycoprotein (P-gp), a product of the MDR1 (ABCB1) gene, m...
Acute effect of ethanol on IgA immunoreactive cells in the intestine-associatedimmune system.
The purpose of this study was to investigate the acute effect of ethanolon mucosa-associated lymphoid tissue at the level of Peyer's patches and the intestinal lamina propriain female rats and to determine whether this a...
Modification of morphine analgesia by venlafaxine in diabetic neuropathic pain model.
Background: The purpose of this study was to investigate the influence of single or chronic (21 days) administration of the serotonin and noradrenaline reuptake inhibitor, venlafaxine, on the antinociceptive action of th...
C3435T polymorphism of the ABCB1 gene: impact on genetic susceptibility to peptic ulcers.
The functional single nucleotide polymorphism (SNP) C3435T in exon 26 of the ABCB1 gene encoding the xenobiotic transporter P-glycoprotein (P-gp) may influence susceptibility to several diseases, as well as the clinical...