Acute effect of ethanol on IgA immunoreactive cells in the intestine-associatedimmune system.
Journal Title: Pharmacological Reports - Year 2005, Vol 57, Issue 3
Abstract
The purpose of this study was to investigate the acute effect of ethanolon mucosa-associated lymphoid tissue at the level of Peyer's patches and the intestinal lamina propriain female rats and to determine whether this action of ethanol is modulated during the estrous cycle.Adult female rats showing proestrus or diestrus day 1 were treated intraperitoneally (ip) with ethanol(4 g/kg). Untreated and saline-injected rats were used as controls. The animals were sacrificed by decapitation0.5 h after ethanol administration. Immunoglobulin A (IgA) immunoreactive cells were analyzed by indirectimmunohistochemistry using mouse anti-rat IgA and a Dako LSAB+ kit. The number of IgA-immunoreactivecells in Peyer's patches was unaltered by ethanol treatment at both phases of the estrous cycle. However,stereological analysis revealed a significant increase in the number of IgA-immunoreactive cells (p
Authors and Affiliations
Mirela Budec, Vera Todorović, Neda Drndarević
Keywords
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