Effect of metformin on selected parameters of hemostasis in fenofibrate-treated patients with impaired glucose tolerance.
Journal Title: Pharmacological Reports - Year 2013, Vol 65, Issue 1
Abstract
Background: No previous study has assessed whether the addition of metformin potentiates fibrate action on hemostasis in prediabetic subjects. Methods: Our study included 41 fenofibrate-treated patients with impaired glucose tolerance allocated to either metformin (3 g daily) or placebo. Results: Twelve-week treatment with fenofibrate and metformin reduced plasma levels of fibrinogen and PAI-1 and tended to change the other hemostatic markers measured, as well as improved insulin sensitivity. Conclusions: Our results show that high-dose metformin exhibits beneficial effects on coagulation and fibrinolysis in isolated IGT patients treated with a fibrate.
Authors and Affiliations
Robert Krysiak, Anna Gdula-Dymek, Bogusław Okopień
Keywords
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