8 Hours Infusional 5-Fluorouracil (5-FU) Concurrent with Neo-Adjuvant Radiotherapy in Locally Advanced Rectal Cancer
Journal Title: Scholars Academic Journal of Biosciences - Year 2015, Vol 3, Issue 5
Abstract
Abstract: In order to selecting optimal treatment regimen in patients suffered advanced rectal cancer, combined adjuvant radiochemotherapy has been found to be more effective than radiotherapy or surgery alone. 5-fluorouracil (5-FU) given concomitantly within the first week of radiotherapy has been shown to be potentially effective, especially before surgical resection of tumor. In the present study, we planned a regimen including preoperative 5-FU infusion within 8 hours concurrently with radiotherapy to assess the efficacy of this protocol without needing hospitalization and with minimizing therapeutic regimen side effects in patients with locally advanced rectal cancer. Sixteen consecutive patients locally advanced rectal cancer (clinical stage T3–T4 or any T stage with positive nodal involvement) received 5FU delivered by continuous infusion within 8 hours, concomitantly with radiotherapy. 5FU dosage was planned at 1000 mg/m2 (ranged 1500 to 1800 mg). Patients were clinically examined and laboratory parameters were assessed every week for six weeks and then were operated. At the 5FU dose of 1000 mg/m2, 8 patients presenting with cytopenia that only 3 of them needed to subcutaneous injection of Neupogen. Gastrointestinal events including diarrhea was revealed in 6 patients that was improved by appropriate nutritional regimen and using Loperamide, but radiotherapy was stopped in other 2 patients. Five patients needed to blood transfusion because of the appearance of serum hemoglobin less than 8.5 g/dl. Two patients were administered to be rest at home for one week. All patients completed their treatment and underwent surgery 6 weeks later. The preoperative radiochemotherapy regimen used in the present study incurs a low rate of complications with an acceptable controlled morbidity. Routine use of preoperative adjuvant chemoradiotherapy including 5-FU 1000 mg/m2 within 8 hours concurrently with radiotherapy can be warranted as standard treatment in locally advanced rectal cancer. Keywords: adjuvant chemoradiotherapy, 5-fluorouracil, rectal cancer
Authors and Affiliations
Mehrsa Majdaeen, Abbas Rahimi, Mohammad Babaei, Masoumeh Karimi, Gholamreza Ataei
Keywords
Related Articles
- EP ID EP379051
- DOI -
- Views 64
- Downloads 0
Asherson’s syndrome: A Case Report
Catastrophic APS (CAPS) is the most severe form of Antiphospholipid antibody syndrome with multiple organ involvement which occurs over a short period of time, usually associated with microthrombosis. We report a case of...
Evaluation of Variations of Haematological Profile of Menopausal Women in Umuahia, Nigeria
Menopause comes with great anticipation. The anticipation could even cause unnecessary fear in the women. The study was done to ascertain the haematological profile of menopausal women as changes usually show in the bloo...
A comparative study of Effect of Rhizobacteria onto seedling vigour of groundnut in in-vitro condition isolated from Kuttch region
Some high salt tolerant Plant Growth Promoting bacteria(BM6, AMAAS57, AMAAS357, R29 and R5) were isolated from Gujarat kuttch region. Their PGP characters were characterized at lab by different biochemical test. To stud...
Visceral Larva Migrans: Case Series
Abstract:Visceral larva Migrans (VLM) due to Toxocara canis or Toxocara cati is rare in developed countries. We report a series of nine cases of eosinophilic liver abscesses that were diagnosed in patients who attended t...
Use of Borom and Lithium Oxides as a Replacement of Fluoride Compounds in Mold Powders
Abstract: The demands on the care of the environment, has impulsed the researchers to develop new mold powders without fluor content in their composition. Nevertheless, the new products need cover the important process r...