(9) ROLE OF TRANEXAMIC ACID FOR REDUCING BLOOD LOSS IN TETRALOGY OF FALLOT
Journal Title: Indian journal of applied basic medical sciences - Year 2014, Vol 16, Issue 22
Abstract
BACKGROUND: Antifibrinolytic agents are used to reduce post-operative blood loss during cardiac surgeries. Paucity of literature on tranexamic acid in patients undergoing tetralogy of fallot repair encouraged us for this study at a tertiary cardiac care center. Administration of antifibrinolytic agent tranexamic acid decreases bleeding and transfusions during postoperative period. METHODS : Sixty pediatric patients undergoing surgical repair for tetralogy of fallot were divided into two groups. The control (Group-A) did not receive the drug while the study group (Group-B) received IV tranexamic acid at pre-incision, during priming and heparin reversal at 10 mg/kg. Blood loss, need for supplementation of blood and blood products, coagulation parameters and re-exploration rate were compared between the groups. RESULTS : Both groups had comparable demographic parameters (age, weight, and body surface area and tetralogy of fallot characteristics). Tranexamic acid treated patients experienced lesser blood loss (p<0.0003), need for PCV (p<0.0001) or Fresh Frozen Plasma (FFP; p<0.0001). Improved coagulation parameters [increased Fibrinogen content (p<0.01) and platelets (p<0.01); decreased activated clotting time (p<0.01) and fibrin degradation product (p<0.01) were also seen in drug treated patients. CONCLUSION: Tranexamic acid was effective in reducing post-operative blood loss with improved coagulation parameters. We therefore advocate its routine use for tetralogy of fallot repair surgeries in pediatric patients.
Authors and Affiliations
R D Patel, Rajesh Thosani
Keywords
Related Articles
- EP ID EP250470
- DOI -
- Views 79
- Downloads 0
13 A COMPARATIVE STUDY OF EFFICACY AND SAFETY OF ULTRASOUNDGUIDED DOUBLE TAP BLOCK WITH CONVENTIONAL REGIONAL ANAESTHESIA FOR OPEN INGUINAL HERNIA REPAIR IN GERIATRIC PATIENTS
Background: Geriatric patients of open hernia repair have comorbidities., Impaired cardiorespiratory reserves ultrasoundguided regional blocks nowadays very popular Aims & objectives: to explore USG guided double TAP bl...
5 A STUDY ON RELATION OF SUBCLINICAL HYPOTHYROIDISM DURING PREGNANCY WITH ITS OUTCOMES IN GUJARAT.
INTRODUCTION:Pregnancy is a period that places great physiological stress on both the mother and the fetus. When pregnancy compounded by endocrine disorders such as hypothyroidism, the potential for maternal and fetal ad...
INDEX IJABMS JULY 2017
1 Editorial: INTEGRATED MEDICAL EDUCATION ORIGINAL ARTICLES 2 STUDY OF RELATIONSHIP BETWEEN SERUM CALCIUM & ARTERIAL BLOOD PRESSURE IN PATIENTS WITH HYPERTENSION . Dr.Rajendra Thorat , Dr.Sachin Mulkutkar,Dr.Shruti.Pand...
(9) ROLE OF TRANEXAMIC ACID FOR REDUCING BLOOD LOSS IN TETRALOGY OF FALLOT
BACKGROUND: Antifibrinolytic agents are used to reduce post-operative blood loss during cardiac surgeries. Paucity of literature on tranexamic acid in patients undergoing tetralogy of fallot repair encouraged us for this...
24 A STUDY OF COMPARISON BETWEEN SILK LIGATION AND BIPOLAR CAUTERY IN TONSILLECTOMY
Background: Tonsillectomy is one of the most commonly performed surgical procedure. Different techniques and instruments have been used for removal of tonsils along with haemostasis but none of them were found satisfacto...