90-90-90 Ambitious Targets: Achieving the Last 90 of the UNAIDS Targets in Western Nigeria
Journal Title: International STD Research & Reviews - Year 2017, Vol 6, Issue 2
Abstract
Background: In resource-limited settings, where genotypic drug resistance testing is rarely performed and poor adherence is regarded as the most common reason for treatment failure, programmatic approaches to handling treatment failure are essential. This study is thus aimed at determining and monitoring HIV/AIDS disease progression using viral load to provide prognostic information and evaluate all patients for viral suppression using the World Health Organization (WHO) guideline strategies. Methods: This study was an observational longitudinal prospective study of subjects living with HIV already initiated on antiretroviral (ARV) therapy for at least six months, with a minimum of two CD4 cell count test done, enrolled at PEPFAR-supported health facilities Ekiti State, Western Nigeria. All data were statistically analysed, using statistical package for the social sciences (SPSS) and statistical test of significance was performed with Chi-Square test while multiple comparisons were done using Post Hoc Bonferonni test. Results: A total of 910 subjects eligible for the study were recruited. Most of them were in the age range of 30 – 44 years, with a mean age ± SD of 40.75 ± 10.33 years. There was a significant increase in the average cell count of the subjects while 787 (86.5%) & 490 (53.9%) of the subjects had viral suppression of <1000 RNA copies per ml and <50 RNA copies per ml respectively on all tests during the period of observation. 96% of the subjects with <50 RNA copies per ml, are currently on first line regimen. Conclusion: HIV treatment intensive adherence counselling is key to the reduction of virologic treatment failure, thus, routine monitoring of viral load alongside CD4 cell count will ultimately reduce treatment failure tendencies thereby helping more patients stay on first line regimen and prolong their life expectancy, indicating that the UNAIDS 90-90-90 targets are achievable in resource-constrained settings.
Authors and Affiliations
Saheed Opeyemi Usman, Oluwole Oluwaniyi, Gbemiga Peter Olubayo, Timothy Akinmurele, Ganiyu Babatunde Agboola, Funmi Abodunde, Abayomi Afe, Olatoun Adeola, Maduakolam Onyema
Keywords
Related Articles
- EP ID EP305454
- DOI 10.9734/ISRR/2017/36534
- Views 135
- Downloads 0
Non-adherence to Highly Active Antiretroviral Therapy and Occurrence of Opportunistic Infections among Adult Clients Accessing Care at a Secondary Health Facility in Imo State Nigeria
Background: Non-adherence remains an issue of concern in highly active anti-retroviral therapy (HAART). It has been reported to reduce the immunological benefit of this regimen, while increasing morbidities and mortaliti...
Syphilis and Human Immunodeficiency Virus Co-infection among Pregnant Women in Nigeria: Prevalence and Trend
Pregnant women are at increased risk of sexually transmitted infections (STIs) due to physiological changes that accompany pregnancy, such as congestion of the cervix, edema of the vaginal mucosa, and alterations in the...
Pattern and Management of Sexually Transmitted Infections (STIs) among Undergraduates Attending University Health Care Centre in Bayelsa State, Nigeria
Sexually transmitted infections are responsible for a variety of health problems, and can have serious consequences on reproductive health of the adolescents and young adults. Thus this study was designed retrospectively...
Coreceptor Usage of Human Immunodeficiency Virus Type 1 Strains in Ibadan, Nigeria
Aims: To evaluate HIV-1 Coreceptor usage in Nigeria. Study Design: Cross-sectional study. Place and Duration of Study: Department of Virology, College of Medicine, University College Hospital, Ibadan from January 2004 to...
Youths' Reproductive Health and Risk Perception to Sexually Transmitted Infections in Communities in Bayelsa State, Nigeria: A Qualitative Study
Aims: Young people especially in sub-Saharan Africa are at great risk of contracting HIV. Studies have shown that young people aged 15–24 account for an estimated 45% of new HIV infections worldwide while less than half...