A 3 Year Retrospective Study of Meningiomas in a Tertiarycare Hospital with an Emphasis on Atypical Meningiomas
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 8
Abstract
Background: Meningiomas are tumours that arise from a layer of tissue (the meninges) that covers the brain and spine. Most are considered “benign” because they are slow-growing with low potential to spread. Methods: This is a retrospective study conducted at Department of neuropathology, Institute of neurosurgery MMC/RGGGH from January 2015 to December 2017.A total of 230 cases of meningiomas were reviewed and classified into grade I,II and III based upon WHO 2016 classification of tumors of CNS. IHC markers were done in deserving cases. Atypical and recurrent meningiomas were analysed and evaluated with proliferation markers and their biologic behaviour studied. Results: In our Institute out of the 1130 cranial and spinal tumors, the incidence of meningioma is 20.35%. Among 132 paediatric tumor cases 2.2% were meningiomas. Out of the 230 meningiomas operated at this Institute, 92.60% were grade 1, 6.08 % were grade II and 1.30% were grade III. The incidence of atypical meningiomas was 4.34 % applying the latest classification. The peak incidence of meningiomas are fourth and fifth decade The recurrence rate was 2.17% . Conclusion : Meningiomas exhibit a broad range of histologic patterns and cellular features In our study we have emphasised that an accurate histopathological interpretation and use of proliferative markers are essential for predicting the prognosis , aggressiveness and recurrence . Further improvements in interobserver concordance will require clarification of subjective morphologic criteria, and identification of objective molecular biomarkers that more accurately predict tumour biology.
Authors and Affiliations
Dr. D. Gowri Manohari, Prof. K. Rama
Keywords
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- DOI 10.9790/0853-1708067783.
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