A Bayesian Meta - Analysis and Systematic Review On Global And Local Prevalence Of Hepatitis B
Journal Title: International Journal of Scientific Research and Management - Year 2014, Vol 2, Issue 12
Abstract
Background: HBV is a global threat, more prevalent in Asia, Latin America, Africa and southern Europe. Pakistan is one of most prevalent countries with approximately 9 million infected. Researchers are trying to investigate the HBV prevalence worldwide but it is too expensive and time consuming to investigate a disease in millions of population. Methods : We carried out a systematic review of the online literature from 2000 - 2013 from the six populated continents with a special focus on Pakistan and its neig hbors. Results: The pooled prevalence rate was found to be 30.49, while in stratified analysis with respect to Pakistan vs neighboring countries, only India (10.23) and china (4.13) were observed to be less prevalent than Pakistan. The OR of Pakistani pop ulation was 0.19 (95% CI 0.09% - 0.35%) against India 0.05(95% CI 0.03 - 0.08), China 0.006 (95% CI 0.005% - 0.007%), Iran 0.24 (95% CI 0.03% - 0.76%), Afghanistan 0.44(95% CI 0.05% - 0.92%) and Bangladesh 0.22 (95% CI 0.03 - 0.70%). A significant heterogeneity was ob served among pattern of results from the collected data. The Egger’s Regression of overall study was - 4.53( - 22.73 to 13.67) while in Pakistani population it was 22.72(4.18 - 41.26). Conclusion : It is to be understood that only a huge countrywide epidemiolog ical study can answer to the general prevalence of HBV in a country like Pakistan with population more than I billion. It is therefore recommended that, the increased risk of HBV among Pakistani population and other related populations needs an effective t esting system and proper legislation should also prepared to protect public health
Authors and Affiliations
Mohammad Haroon Khan
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