A BIOCHEMICAL APPROACH TO LACTATE DEHYDROGENASE IN ASCITIC/PLEURAL FLUID IN A TERTIARY CARE HOSPITAL
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2019, Vol 8, Issue 2
Abstract
BACKGROUND Lactate dehydrogenase (LDH) is an enzyme which is found in almost all living cells. LDH is a tetramer composed of two different subunits, M and H. It catalyses the interconversion of lactate and pyruvate, as it interconverts NAD+ and NADH. The aim of this study was to evaluate the diagnostic significance of estimating lactate dehydrogenase in ascitic and pleural fluid. MATERIALS AND METHODS The current study was conducted in the department of biochemistry at Saraswathi Institute of Medical Sciences, Hapur. This descriptive study was performed on 60 subjects suffering from ascites/pleural effusion, who satisfy the inclusion and exclusion criteria. Since the duration of the study was less, patients were selected by convenience technique. RESULTS Estimating the fluid lactate dehydrogenase levels in patients presenting with ascites helps in differentiating between malignant and non-malignant effusions. It is highly sensitive (100%) and highly specific (100%). Estimating the fluid lactate dehydrogenase level in patients presenting with pleural effusion helps in differentiating between transudative and exudative effusions. It is highly sensitive (100%) and highly specific (100%). CONCLUSION Biochemical analysis of LDH in ascitic fluid helps in differentiating malignant and non-malignant aetiology (Negative Predictive Value= 100%, Confidence Interval= 75.3-100%).
Authors and Affiliations
Vivek Sinha, Poonam Kachhawa
Keywords
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- EP ID EP553080
- DOI 10.14260/jemds/2019/31
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