A case control study on effect of 1% phenytoin irrigation during modified radical mastectomy at tertiary care centre
Journal Title: Medpulse International Journal of Surgery - Year 2019, Vol 10, Issue 3
Abstract
Background: Worldwide, breast cancer is the most frequently diagnosed life-threatening cancer in women. In less-developed countries, it is the leading cause of cancer death in women. Phenytoin is known to reduce incidence of seroma post mastectomy in breast cancer patient. Objectives: To see the effect of 1% phenytoin irrigation during Modified Radical Mastectomy at tertiary care centre. Material and Methods: This was a prospective randomized placebo control study was conducted at Sir Sayajirao General Hospital Baroda, Vadodara to study the effect of wound irrigation with 1% topical phenytoin during modified radical mastectomy on post-operative seroma formation, from September 2016 to September 2017. 36 patients were enrolled in the study, 18 were allotted to the phenytoin group and 18 allotted to the control group. Patients were followed for 1 month after surgery. Data was entered in Microsoft excel and analyzed using SPSS vr20. Results: 25% incidence of seroma was found amongst the patients undergoing modified radical mastectectomy. Significant association between irrigation with topical phenytoin and decrease in seroma formation was not established in present study. No local side effects of phenytoin solution were observed. The association of seroma formation with irrigation with topical phenytoin was not established in this study. The total drainage from the wound was lower in patients in the phenytoin group compared to the control group (400mlvs511ml). No significant decrease in the day of drain removal was reported between cases and control (7 vs 7.16 days). No significant difference between day of drain, duration of hospital stay was observed in patients in case group compared to patients in control group. It is observed that neoadjuvant therapy is a significant risk factor in seroma formation. 11 patients took neoadjuvant chemotherapy out of which 7 had seroma formation (54%). No significant difference is found between age of patients with seroma and patients without seroma and surgical site infection was noted in case group compared to control group. Conclusions: No significant benefit of phenytoin in preventing seroma was established in the present study.
Authors and Affiliations
Divyang H Chavda, Dhwani A Shah
Keywords
Related Articles
- EP ID EP614360
- DOI 10.26611/10610313
- Views 171
- Downloads 0
A study of clinical profile of patients with bile stone at tertiary health care centre
Background: Diseases of the gallbladder are common and costly. Gallstone disease is a chronic recurrent hepatobiliary disease, the basis for which is the impaired metabolism of cholesterol, bilirubin and bile acids, whic...
Stapled hemorrhoidectomy Vs conventional hemorrhoidectomy – Surgical outcome in Indian population
Background: Stapled hemorrhoidectomy a technique which is concerned with less postoperative pain and lesser morbidity compared to conventional procedures in the treatment of hemorrhoids. This study proposes to compare th...
Diagnostic and Prognostic value of CRP, Procalcitonin and WBC in Acute Abdomen Management
Acute inflammatory conditions of abdomen refers as acute abdomen. This includes signs and symptoms of abdominal pain and tenderness. After detailed clinical examinations, this condition often requires emergency surgical...
A study of role of limberg flap for Sacro-Coccygeal pilonidal sinus
Background: Sacro-Coccygeal pilonidal sinus is a common disease of the adult age group, especially male population, causing significant morbidity from both disease and surgery done for the same. It is essentially a cleav...
Clinical profile and management of peripheral vascular disease
Background: Peripheral vascular disease (PVD) refers to diseases of the blood vessels (arteries and veins) located outside the heart and brain. Disease is quite prevalent in indian settings, so we tried to study its prof...